Search Results - "Pereira, Claudia"

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation by Bacman, Sandra R., Kauppila, Johanna H. K., Pereira, Claudia V., Nissanka, Nadee, Miranda, Maria, Pinto, Milena, Williams, Sion L., Larsson, Nils-Göran, Stewart, James B., Moraes, Carlos T.

“…Mutations in the mitochondrial DNA (mtDNA) are responsible for several metabolic disorders, commonly involving muscle and the central nervous system 1 …”
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The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway by Ferreiro, Elisabete, Oliveira, Catarina R, Pereira, Cláudia M.F

“…Abstract In this study, we analyzed whether ER Ca2+ release, induced by amyloid-β (Aβ) and prion (PrP) peptides activates the mitochondrial-mediated apoptotic…”
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Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets by Pereira, Ana Catarina, Oliveira, Joana, Silva, Sónia, Madeira, Nuno, Pereira, Cláudia M.F., Cruz, Maria T.

“…[Display omitted] Bipolar disorder (BD) is a chronic and cyclic mental disorder, characterized by unusual mood swings between mania/hypomania and depression,…”
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Cellular mechanisms of mtDNA heteroplasmy dynamics by Pereira, Claudia V, Gitschlag, Bryan L, Patel, Maulik R

“…Heteroplasmy refers to the coexistence of more than one variant of the mitochondrial genome (mtDNA). Mutated or partially deleted mtDNAs can induce chronic…”
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Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo by Zekonyte, Ugne, Bacman, Sandra R., Smith, Jeff, Shoop, Wendy, Pereira, Claudia V., Tomberlin, Ginger, Stewart, James, Jantz, Derek, Moraes, Carlos T.

“…Diseases caused by heteroplasmic mitochondrial DNA mutations have no effective treatment or cure. In recent years, DNA editing enzymes were tested as tools to…”
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Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release by Ferreira, Ildete Luísa, Ferreiro, Elisabete, Schmidt, Jeannette, Cardoso, João M, Pereira, Cláudia M.F, Carvalho, Ana Luísa, Oliveira, Catarina R, Rego, A. Cristina

“…Abstract Early cognitive deficits in Alzheimer's disease (AD) seem to be correlated to dysregulation of glutamate receptors evoked by amyloid-beta (Aβ)…”
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Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease by Bento‐Pereira, Claudia, Dinkova‐Kostova, Albena T.

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder, for which no disease‐modifying therapies are available to date. Although understanding of…”
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Polymicrobial ventilator-associated pneumonia : fighting in vitro Candida albicans-Pseudomonas aeruginosa biofilms with antifungal-antibacterial combination therapy by Rodrigues, E., Lopes, Susana Patrícia, Pereira, C., Azevedo, Nuno Filipe, Lourenço, Anália, Henriques, Mariana, Pereira, Maria Olívia

“…The polymicrobial nature of ventilator-associated pneumonia (VAP) is now evident, with mixed bacterial-fungal biofilms colonizing the VAP endotracheal tube…”
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Mapping the lipidome in mitochondria‐associated membranes (MAMs) in an in vitro model of Alzheimer's disease by Fernandes, Tânia, Melo, Tânia, Conde, Tiago, Neves, Bruna, Domingues, Pedro, Resende, Rosa, Pereira, Cláudia F., Moreira, Paula I., Domingues, Maria Rosário

“…The disruption of mitochondria‐associated endoplasmic reticulum (ER) membranes (MAMs) plays a relevant role in Alzheimer's disease (AD). MAMs have been…”
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Burden of disease in Brazil, 1990–2016: a systematic subnational analysis for the Global Burden of Disease Study 2016 by Marinho, Fatima, de Azeredo Passos, Valéria Maria, Carvalho Malta, Deborah, Barboza França, Elizabeth, Abreu, Daisy M X, Araújo, Valdelaine E M, Bustamante-Teixeira, Maria Teresa, Camargos, Paulo A M, da Cunha, Carolina Cândida, Duncan, Bruce Bartholow, Felisbino-Mendes, Mariana Santos, Guerra, Maximiliano Ribeiro, Guimaraes, Mark D C, Lotufo, Paulo A, Marcenes, Wagner, Oliveira, Patricia Pereira Vasconcelos, de Moares Pedroso, Marcel, Ribeiro, Antonio L, Schmidt, Maria Inês, Teixeira, Renato Azeredo, Vasconcelos, Ana Maria Nogales, Barreto, Mauricio L, Bensenor, Isabela M, Brant, Luisa C C, Claro, Rafael M, Costa Pereira, Alexandre, Cousin, Ewerton, Curado, Maria Paula, dos Santos, Kadine Priscila Bender, Faro, André, Ferri, Cleusa P, Furtado, João M, Gall, Julia, Glenn, Scott D, Goulart, Alessandra Carvalho, Ishitani, Lenice Harumi, Kieling, Christian, Ladeira, Roberto Marini, Machado, Isis Eloah, Martins, Sheila Cristina Ouriques, Martins-Melo, Francisco Rogerlândio, Melo, Ana Paula Souto, Miller-Petrie, Molly K, Mooney, Meghan D, Nunes, Bruno P, Palone, Marcos Roberto Tovani, Pereira, Claudia C, Rasella, Davide, Ray, Sarah E, Roever, Leonardo, de Freitas Saldanha, Raphael, Santos, Itamar S, Schneider, Ione J C, Santos Silva, Diego Augusto, Silveira, Dayane Gabriele Alves, Soares Filho, Adauto Martins, Moraes Sousa, Tatiane Cristina, Szwarcwald, Celia L, Traebert, Jefferson, Velasquez-Melendez, Gustavo, Wang, Yuan-Pang, Lozano, Rafael, Murray, Christopher J L, Naghavi, Mohsen

“…Political, economic, and epidemiological changes in Brazil have affected health and the health system. We used the Global Burden of Disease Study 2016 (GBD…”
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Myopathy reversion in mice after restauration of mitochondrial complex I by Pereira, Claudia V, Peralta, Susana, Arguello, Tania, Bacman, Sandra R, Diaz, Francisca, Moraes, Carlos T

“…Myopathies are common manifestations of mitochondrial diseases. To investigate whether gene replacement can be used as an effective strategy to treat or cure…”
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Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells by Fonseca, Ana Catarina R.G., Ferreiro, Elisabete, Oliveira, Catarina R., Cardoso, Sandra M., Pereira, Cláudia F.

“…Neurovascular dysfunction arising from endothelial cell damage is an early pathogenic event that contributes to the neurodegenerative process occurring in…”
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An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity by Ferreiro, Elisabete, Resende, Rosa, Costa, Rui, Oliveira, Catarina R., Pereira, Cláudia M.F.

“…Prion (PrP) and amyloid-β (Aβ) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively,…”
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Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions by Costa, Rui O, Ferreiro, Elisabete, Martins, Isaura, Santana, Isabel, Cardoso, Sandra M, Oliveira, Catarina R, Pereira, Cláudia M.F

“…Abstract Previously we reported that endoplasmic reticulum (ER)-mitochondria crosstalk is involved in amyloid-β (Aβ)-induced apoptosis. Now we show that…”
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ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system by Pereira, Ana Catarina, De Pascale, Jessica, Resende, Rosa, Cardoso, Susana, Ferreira, Isabel, Neves, Bruno Miguel, Carrascal, Mylène A., Zuzarte, Mónica, Madeira, Nuno, Morais, Sofia, Macedo, António, do Carmo, Anália, Moreira, Paula I., Cruz, Maria Teresa, Pereira, Cláudia F.

“…Endoplasmic reticulum (ER) stress and mitochondrial dysfunction, which are key events in the initiation and/or progression of several diseases, are correlated…”
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COVID-19 hospitalizations in Brazil's Unified Health System (SUS) by de Andrade, Carla Lourenço Tavares, Pereira, Claudia Cristina de Aguiar, Martins, Mônica, Lima, Sheyla Maria Lemos, Portela, Margareth Crisóstomo

“…To study the profile of hospitalizations due to COVID-19 in the Unified Health System (SUS) in Brazil and to identify factors associated with in-hospital…”
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Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy by Baek, Jin Hyen, D'Agnillo, Felice, Vallelian, Florence, Pereira, Claudia P, Williams, Matthew C, Jia, Yiping, Schaer, Dominik J, Buehler, Paul W

“…Massive transfusion of blood can lead to clinical complications, including multiorgan dysfunction and even death. Such severe clinical outcomes have been…”
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Fungal diseases in children and adolescents in a referral centre in Bogota, Colombia by Alvarado, Zulma, Pereira, Claudia

“…Summary A cross‐sectional descriptive study was conducted at a dermatology referral centre in Bogotá, to estimate the frequencies and aetiologies of mycoses in…”
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Bovine whey proteins – Overview on their main biological properties by Madureira, Ana R., Pereira, Cláudia I., Gomes, Ana M.P., Pintado, Manuela E., Xavier Malcata, F.

“…Whey, a liquid by-product, is widely accepted to contain many valuable constituents. These include especially proteins that possess important nutritional and…”
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mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels by Pereira, Claudia V, Bacman, Sandra R, Arguello, Tania, Zekonyte, Ugne, Williams, Sion L, Edgell, David R, Moraes, Carlos T

“…Pathogenic mitochondrial DNA (mtDNA) mutations often co‐exist with wild‐type molecules (mtDNA heteroplasmy). Phenotypes manifest when the percentage of mutant…”
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