Search Results - "Pereira, Cláudia V"

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts by Coelho, Ana R., Martins, Tatiana R., Couto, Renata, Deus, Cláudia, Pereira, Cláudia V., Simões, Rui F., Rizvanov, Albert A., Silva, Filomena, Cunha-Oliveira, Teresa, Oliveira, Paulo J., Serafim, Teresa L.

“…Doxorubicin (DOX) is one of the most widely used anti-neoplastic agents. However, treatment with DOX is associated with cumulative cardiotoxicity inducing…”
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Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia by Lumini-Oliveira, José, Magalhães, José, Pereira, Cláudia V, Moreira, Ana C, Oliveira, Paulo J, Ascensão, António

“…The present study analyzed the effects of endurance training against cardiac mitochondrial dysfunction, particularly on the susceptibility to mitochondrial…”
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Mechanisms of Berberine (Natural Yellow 18)–Induced Mitochondrial Dysfunction: Interaction with the Adenine Nucleotide Translocator by Pereira, Cláudia V., Machado, Nuno G., Oliveira, Paulo J.

“…Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium] is an alkaloid present in plants of the Berberidaceae…”
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Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats by Pereira, Susana P., Pereira, Gonçalo C., Pereira, Cláudia V., Carvalho, Filipa S., Cordeiro, Marília H., Mota, Paula C., Ramalho-Santos, João, Moreno, António J., Oliveira, Paulo J.

“…The environmental dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is classified as a Group 1 human carcinogen and teratogenic agent. We hypothesize that…”
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Rapeseed oil-rich diet alters hepatic mitochondrial membrane lipid composition and disrupts bioenergetics by Monteiro, João P., Pereira, Cláudia V., Silva, Ana M., Maciel, Elisabete, Baldeiras, Inês, Peixoto, Francisco, Domingues, Maria R., Jurado, Amália S., Oliveira, Paulo J.

“…Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial…”
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Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety? by Pereira, Cláudia V, Moreira, Ana C, Pereira, Susana P, Machado, Nuno G, Carvalho, Filipa S, Sardão, Vilma A, Oliveira, Paulo J

“…Mitochondria are recognized as the producers of the majority of energy cells need for their normal activity. After the initial comprehension of how…”
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Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition by Burgeiro, Ana, Pereira, Cláudia V, Carvalho, Filipa S, Pereira, Gonçalo C, Mollinedo, Faustino, Oliveira, Paulo J

“…Edelfosine and perifosine are alkylphospholipids that have been intensively studied as potential antitumor agents. Apoptotic cell death caused by these two…”
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Long-term hyperglycaemia decreases gastrocnemius susceptibility to permeability transition by Lumini-Oliveira, José, Ascensão, António, Pereira, Cláudia V., Magalhães, Sérgio, Marques, Franklin, Oliveira, Paulo J., Magalhães, José

“…Eur J Clin Invest 2010; 40 (4): 319–329 Background  Hyperglycaemia‐resulting in mitochondrial bioenergetics’ complications is associated with skeletal muscle…”
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MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation by Bacman, Sandra R., Kauppila, Johanna H. K., Pereira, Claudia V., Nissanka, Nadee, Miranda, Maria, Pinto, Milena, Williams, Sion L., Larsson, Nils-Göran, Stewart, James B., Moraes, Carlos T.

“…Mutations in the mitochondrial DNA (mtDNA) are responsible for several metabolic disorders, commonly involving muscle and the central nervous system 1 …”
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Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo by Zekonyte, Ugne, Bacman, Sandra R., Smith, Jeff, Shoop, Wendy, Pereira, Claudia V., Tomberlin, Ginger, Stewart, James, Jantz, Derek, Moraes, Carlos T.

“…Diseases caused by heteroplasmic mitochondrial DNA mutations have no effective treatment or cure. In recent years, DNA editing enzymes were tested as tools to…”
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Endurance training improves gastrocnemius mitochondrial function despite increased susceptibility to permeability transition by Lumini-Oliveira, José, Magalhães, José, Pereira, Cláudia V, Aleixo, Inês, Oliveira, Paulo J, Ascensão, António

“…The aim of the present work was to test the hypothesis that moderate endurance treadmill training ameliorates gastrocnemius mitochondrial bioenergetics and…”
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mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels by Pereira, Claudia V, Bacman, Sandra R, Arguello, Tania, Zekonyte, Ugne, Williams, Sion L, Edgell, David R, Moraes, Carlos T

“…Pathogenic mitochondrial DNA (mtDNA) mutations often co‐exist with wild‐type molecules (mtDNA heteroplasmy). Phenotypes manifest when the percentage of mutant…”
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Multiple distinct evolutionary mechanisms govern the dynamics of selfish mitochondrial genomes in Caenorhabditis elegans by Gitschlag, Bryan L., Pereira, Claudia V., Held, James P., McCandlish, David M., Patel, Maulik R.

“…Cells possess multiple mitochondrial DNA (mtDNA) copies, which undergo semi-autonomous replication and stochastic inheritance. This enables mutant mtDNA…”
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Myopathy reversion in mice after restauration of mitochondrial complex I by Pereira, Claudia V, Peralta, Susana, Arguello, Tania, Bacman, Sandra R, Diaz, Francisca, Moraes, Carlos T

“…Myopathies are common manifestations of mitochondrial diseases. To investigate whether gene replacement can be used as an effective strategy to treat or cure…”
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Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation by Madsen, Pernille M, Pinto, Milena, Patel, Shreyans, McCarthy, Stephanie, Gao, Han, Taherian, Mehran, Karmally, Shaffiat, Pereira, Claudia V, Dvoriantchikova, Galina, Ivanov, Dmitry, Tanaka, Kenji F, Moraes, Carlos T, Brambilla, Roberta

“…Mitochondrial dysfunction has been implicated in the pathophysiology of neurodegenerative disorders, including multiple sclerosis (MS). To date, the…”
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A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response by Held, James P, Feng, Gaomin, Saunders, Benjamin R, Pereira, Claudia V, Burkewitz, Kristopher, Patel, Maulik R

“…The mitochondrial unfolded protein response (UPR ) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple…”
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Mitochondrionopathy phenotype in doxorubicin-treated Wistar rats depends on treatment protocol and is cardiac-specific by Pereira, Gonçalo C, Pereira, Susana P, Pereira, Claudia V, Lumini, José A, Magalhães, José, Ascensão, António, Santos, Maria S, Moreno, António J, Oliveira, Paulo J

“…Although doxorubicin (DOX) is a very effective antineoplastic agent, its clinical use is limited by a dose-dependent, persistent and cumulative cardiotoxicity,…”
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Cellular mechanisms of mtDNA heteroplasmy dynamics by Pereira, Claudia V, Gitschlag, Bryan L, Patel, Maulik R

“…Heteroplasmy refers to the coexistence of more than one variant of the mitochondrial genome (mtDNA). Mutated or partially deleted mtDNAs can induce chronic…”
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Current strategies towards therapeutic manipulation of mtDNA heteroplasmy by Pereira, Claudia V, Moraes, Carlos T

“…Mitochondrial disease is a multifactorial disorder involving both nuclear and mitochondrial genomes. Over the past 20 years, great progress was achieved in the…”
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SCO2 mutations cause early-onset axonal Charcot-Marie-Tooth disease associated with cellular copper deficiency by Rebelo, Adriana P, Saade, Dimah, Pereira, Claudia V, Farooq, Amjad, Huff, Tyler C, Abreu, Lisa, Moraes, Carlos T, Mnatsakanova, Diana, Mathews, Kathy, Yang, Hua, Schon, Eric A, Zuchner, Stephan, Shy, Michael E

“…Recessive mutations in the mitochondrial copper-binding protein SCO2 have been described in cases of fatal infant cardioencephalomyopathy with COX deficiency…”
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