Search Results - "Perego, Roberto A."

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells by De Simone, Marco, Arrigoni, Alberto, Rossetti, Grazisa, Gruarin, Paola, Ranzani, Valeria, Politano, Claudia, Bonnal, Raoul J.P., Provasi, Elena, Sarnicola, Maria Lucia, Panzeri, Ilaria, Moro, Monica, Crosti, Mariacristina, Mazzara, Saveria, Vaira, Valentina, Bosari, Silvano, Palleschi, Alessandro, Santambrogio, Luigi, Bovo, Giorgio, Zucchini, Nicola, Totis, Mauro, Gianotti, Luca, Cesana, Giancarlo, Perego, Roberto A., Maroni, Nirvana, Pisani Ceretti, Andrea, Opocher, Enrico, De Francesco, Raffaele, Geginat, Jens, Stunnenberg, Hendrik G., Abrignani, Sergio, Pagani, Massimiliano

“…Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for tumor antigens. Deeper molecular definitions of…”
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High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures by Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Cifola, Ingrid, Morabito, Ivana, Invernizzi, Lara, Meregalli, Chiara, Zucchini, Nicola, Strada, Guido, Perego, Roberto A, Bianchi, Cristina

“…Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT)…”
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Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma by Lucarelli, Giuseppe, Rutigliano, Monica, Sallustio, Fabio, Ribatti, Domenico, Giglio, Andrea, Lepore Signorile, Martina, Grossi, Valentina, Sanese, Paola, Napoli, Anna, Maiorano, Eugenio, Bianchi, Cristina, Perego, Roberto A, Ferro, Matteo, Ranieri, Elena, Serino, Grazia, Bell, Lauren N, Ditonno, Pasquale, Simone, Cristiano, Battaglia, Michele

“…An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), and in this tumor many altered genes play a fundamental role…”
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The glucose and lipid metabolism reprogramming is grade-dependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell viability and proliferation by Bianchi, Cristina, Meregalli, Chiara, Bombelli, Silvia, Di Stefano, Vitalba, Salerno, Francesco, Torsello, Barbara, De Marco, Sofia, Bovo, Giorgio, Cifola, Ingrid, Mangano, Eleonora, Battaglia, Cristina, Strada, Guido, Lucarelli, Giuseppe, Weiss, Robert H, Perego, Roberto A

“…Clear cell renal cell carcinoma (ccRCC) has a poor prognosis despite novel biological targeted therapies. Tumor aggressiveness and poor survival may correlate…”
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Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma by Lucarelli, Giuseppe, Ferro, Matteo, Loizzo, Davide, Bianchi, Cristina, Terracciano, Daniela, Cantiello, Francesco, Bell, Lauren N, Battaglia, Stefano, Porta, Camillo, Gernone, Angela, Perego, Roberto A, Maiorano, Eugenio, Cobelli, Ottavio de, Castellano, Giuseppe, Vincenti, Leonardo, Ditonno, Pasquale, Battaglia, Michele

“…Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, in this study we…”
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Correction: The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently by Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Chisci, Elisa, Cassina, Valeria, Corti, Roberta, Bernasconi, Davide, Giovannoni, Roberto, Bianchi, Cristina, Perego, Roberto A.

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36-kDa Annexin A3 Isoform Negatively Modulates Lipid Storage in Clear Cell Renal Cell Carcinoma Cells by Bombelli, Silvia, Torsello, Barbara, De Marco, Sofia, Lucarelli, Giuseppe, Cifola, Ingrid, Grasselli, Chiara, Strada, Guido, Bovo, Giorgio, Perego, Roberto A., Bianchi, Cristina

“…The adipocyte-like morphology of clear cell renal cell carcinoma (ccRCC) cells results from a grade-dependent neutral lipid accumulation; however, the…”
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Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia by Fontana, Diletta, Ramazzotti, Daniele, Aroldi, Andrea, Redaelli, Sara, Magistroni, Vera, Pirola, Alessandra, Niro, Antonio, Massimino, Luca, Mastini, Cristina, Brambilla, Virginia, Bombelli, Silvia, Bungaro, Silvia, Morotti, Alessandro, Rea, Delphine, Stagno, Fabio, Martino, Bruno, Campiotti, Leonardo, Caocci, Giovanni, Usala, Emilio, Merli, Michele, Onida, Francesco, Bregni, Marco, Elli, Elena Maria, Fumagalli, Monica, Ciceri, Fabio, Perego, Roberto A., Pagni, Fabio, Mologni, Luca, Piazza, Rocco, Gambacorti‐Passerini, Carlo

“…Supplemental Digital Content is available for this article. Atypical chronic myeloid leukemia (aCML) is a BCR‐ABL1‐negative clonal disorder, which belongs to…”
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The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently by Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Chisci, Elisa, Cassina, Valeria, Corti, Roberta, Bernasconi, Davide, Giovannoni, Roberto, Bianchi, Cristina, Perego, Roberto A

“…The fibrotic tissue and the stroma adjacent to cancer cells are characterised by the presence of activated fibroblasts (myofibroblasts) which play a role in…”
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PKHhigh/CD133+/CD24− Renal Stem-Like Cells Isolated from Human Nephrospheres Exhibit In Vitro Multipotency by Bombelli, Silvia, Meregalli, Chiara, Grasselli, Chiara, Bolognesi, Maddalena M., Bruno, Antonino, Eriani, Stefano, Torsello, Barbara, De Marco, Sofia, Bernasconi, Davide P., Zucchini, Nicola, Mazzola, Paolo, Bianchi, Cristina, Grasso, Marco, Albini, Adriana, Cattoretti, Giorgio, Perego, Roberto A.

“…The mechanism upon which human kidneys undergo regeneration is debated, though different lineage-tracing mouse models have tried to explain the cellular types…”
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The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells by De Marco, Sofia, Torsello, Barbara, Minutiello, Emanuela, Morabito, Ivana, Grasselli, Chiara, Bombelli, Silvia, Zucchini, Nicola, Lucarelli, Giuseppe, Strada, Guido, Perego, Roberto A., Bianchi, Cristina

“…Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological cancer. Molecular players of ccRCC progression and metastasis are not…”
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Renal cell carcinoma primary cultures maintain genomic and phenotypic profile of parental tumor tissues by Cifola, Ingrid, Bianchi, Cristina, Mangano, Eleonora, Bombelli, Silvia, Frascati, Fabio, Fasoli, Ester, Ferrero, Stefano, Di Stefano, Vitalba, Zipeto, Maria A, Magni, Fulvio, Signorini, Stefano, Battaglia, Cristina, Perego, Roberto A

“…Clear cell renal cell carcinoma (ccRCC) is characterized by recurrent copy number alterations (CNAs) and loss of heterozygosity (LOH), which may have potential…”
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DNA Damage in Circulating Hematopoietic Progenitor Stem Cells as Promising Biological Sensor of Frailty by Grasselli, Chiara, Bombelli, Silvia, Eriani, Stefano, Domenici, Giulia, Galluccio, Riccardo, Tropeano, Chiara, De Marco, Sofia, Bolognesi, Maddalena M, Torsello, Barbara, Bianchi, Cristina, Antolini, Laura, Rossi, Fabio, Mazzola, Paolo, Leoni, Valerio, Bellelli, Giuseppe, Perego, Roberto A

“…Abstract Frailty is an age-related syndrome that exposes individuals to increased vulnerability. Although it is potentially reversible, in most cases it leads…”
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Impairment of Renal and Hematopoietic Stem/Progenitor Cell Compartments in Frailty Syndrome: Link With Oxidative Stress, Plasma Cytokine Profiles, and Nuclear DNA Damage by Bombelli, Silvia, Grasselli, Chiara, Mazzola, Paolo, Veronesi, Valentina, Morabito, Ivana, Zucchini, Nicola, Scollo, Chiara M, Blanco, Salvatore I, De Marco, Sofia, Torsello, Barbara, Vitarelli, Federica, Antolini, Laura, Bianchi, Cristina, Leoni, Valerio, Bellelli, Giuseppe, Perego, Roberto A

“…Abstract Frailty is an age-related syndrome that drives multiple physiological system impairments in some older adults, and its pathophysiological mechanisms…”
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Expression of heat shock protein 27 in human renal cell carcinoma by Sarto, Cecilia, Valsecchi, Cristina, Magni, Fulvio, Tremolada, Lucia, Arizzi, Carmelo, Cordani, Nicoletta, Casellato, Stefano, Doro, Giancarlo, Favini, Paolo, Perego, Roberto A., Raimondo, Francesca, Ferrero, Stefano, Mocarelli, Paolo, Galli-Kienle, Marzia

“…Heat shock protein 27 (HSP27, Swiss‐Prot accession number P04792) is a component of the large and heterogeneous group of chaperone proteins, and its main…”
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Nephrosphere-Derived Cells Are Induced to Multilineage Differentiation when Cultured on Human Decellularized Kidney Scaffolds by Bombelli, Silvia, Meregalli, Chiara, Scalia, Carla, Bovo, Giorgio, Torsello, Barbara, De Marco, Sofia, Cadamuro, Massimiliano, Viganò, Paolo, Strada, Guido, Cattoretti, Giorgio, Bianchi, Cristina, Perego, Roberto A.

“…In end-stage chronic kidney disease, the option of organ transplantation is limited because of the scarce availability of kidneys. The combination of stem cell…”
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Retraction: Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions by Torsello, Barbara, Bianchi, Cristina, Meregalli, Chiara, Stefano, Vitalba Di, Invernizzi, Lara, Marco, Sofia De, Bovo, Giorgio, Brivio, Rinaldo, Strada, Guido, Bombelli, Silvia, Perego, Roberto A.

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Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures by Di Stefano, Vitalba, Torsello, Barbara, Bianchi, Cristina, Cifola, Ingrid, Mangano, Eleonora, Bovo, Giorgio, Cassina, Valeria, De Marco, Sofia, Corti, Roberta, Meregalli, Chiara, Bombelli, Silvia, Viganò, Paolo, Battaglia, Cristina, Strada, Guido, Perego, Roberto A

“…Human clear cell renal cell carcinoma (ccRCC) is therapy resistant; therefore, it is worthwhile studying in depth the molecular aspects of its progression. In…”
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Correction: Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions (doi:10.1242/jcs.183640) by Torsello, Barbara, Bianchi, Cristina, Meregalli, Chiara, Di Stefano, Vitalba, Invernizzi, Lara, De Marco, Sofia, Bovo, Giorgio, Brivio, Rinaldo, Strada, Guido, Bombelli, Silvia, Perego, Roberto A.

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Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions by Torsello, Barbara, Bianchi, Cristina, Meregalli, Chiara, Di Stefano, Vitalba, Invernizzi, Lara, De Marco, Sofia, Bovo, Giorgio, Brivio, Rinaldo, Strada, Guido, Bombelli, Silvia, Perego, Roberto A

“…Renal tubular cells are involved in the tubular interstitial fibrosis observed in diabetic nephropathy. It is debated whether epithelial-mesenchymal transition…”
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