Search Results - "Perego, Michela"

Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation by He, Yu-Mei, Li, Xing, Perego, Michela, Nefedova, Yulia, Kossenkov, Andrew V, Jensen, Erik A, Kagan, Valerian, Liu, Yu-Feng, Fu, Shu-Yu, Ye, Qing-Jian, Zhou, Yan-Hong, Wei, Lai, Gabrilovich, Dmitry I, Zhou, Jie

“…Myeloid-derived suppressor cells are induced in newborn mice by breast-milk-derived lactoferrin and confer protection in a model of necrotizing enterocolitis…”
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Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer by Kwak, Taekyoung, Wang, Fang, Deng, Hui, Condamine, Thomas, Kumar, Vinit, Perego, Michela, Kossenkov, Andrew, Montaner, Luis J., Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Mulligan, Charles, Nam, Brian, Masters, Gregory, Hockstein, Neil, Bennett, Joseph, Nefedova, Yulia, Gabrilovich, Dmitry I.

“…Here, we report that functional heterogeneity of macrophages in cancer could be determined by the nature of their precursors: monocytes (Mons) and monocytic…”
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Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice by Liu, Yufeng, Perego, Michela, Xiao, Qiang, He, Yumei, Fu, Shuyu, He, Juan, Liu, Wangkai, Li, Xing, Tang, Yanlai, Li, Xiaoyu, Yuan, Weiming, Zhou, Wei, Wu, Fan, Jia, Chunhong, Cui, Qiliang, Worthen, George S, Jensen, Erik A, Gabrilovich, Dmitry I, Zhou, Jie

“…Inflammation plays a critical role in the development of severe neonatal morbidities. Myeloid-derived suppressor cells (MDSCs) were recently implicated in the…”
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Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions by Bertolini, Irene, Perego, Michela, Nefedova, Yulia, Lin, Cindy, Milcarek, Andrew, Vogel, Peter, Ghosh, Jagadish C, Kossenkov, Andrew V, Altieri, Dario C

“…The origin of breast cancer, whether primary or recurrent, is unknown. Here, we show that invasive breast cancer cells exposed to hypoxia release small…”
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Mitochondrial fitness and cancer risk by Kossenkov, Andrew V, Milcarek, Andrew, Notta, Faiyaz, Jang, Gun-Ho, Wilson, Julie M, Gallinger, Steven, Zhou, Daniel Cui, Ding, Li, Ghosh, Jagadish C, Perego, Michela, Morotti, Annamaria, Locatelli, Marco, Robert, Marie E, Vaira, Valentina, Altieri, Dario C

“…Changes in metabolism are a hallmark of cancer, but molecular signatures of altered bioenergetics to aid in clinical decision-making do not currently exist. We…”
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Mitochondrial fitness and cancer risk by Andrew V Kossenkov, Andrew Milcarek, Faiyaz Notta, Gun-Ho Jang, Julie M Wilson, Steven Gallinger, Daniel Cui Zhou, Li Ding, Jagadish C Ghosh, Michela Perego, Annamaria Morotti, Marco Locatelli, Marie E Robert, Valentina Vaira, Dario C Altieri

“…Changes in metabolism are a hallmark of cancer, but molecular signatures of altered bioenergetics to aid in clinical decision-making do not currently exist. We…”
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Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness by Monti, Matilde, Benerini Gatta, Luisa, Bugatti, Mattia, Pezzali, Irene, Picinoli, Sara, Manfredi, Marcello, Lavazza, Antonio, Vanella, Virginia Vita, De Giorgis, Veronica, Zanatta, Lucia, Missale, Francesco, Lonardi, Silvia, Zanetti, Benedetta, Bozzoni, Giovanni, Cadei, Moris, Abate, Andrea, Vergani, Barbara, Balzarini, Piera, Battocchio, Simonetta, Facco, Carla, Turri-Zanoni, Mario, Castelnuovo, Paolo, Nicolai, Piero, Fonsatti, Ester, Leone, Biagio Eugenio, Marengo, Emilio, Sigala, Sandra, Ronca, Roberto, Perego, Michela, Lombardi, Davide, Vermi, William

“…Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with…”
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Comparative Secretome Analysis of Epithelial and Mesenchymal Subpopulations of Head and Neck Squamous Cell Carcinoma Identifies S100A4 as a Potential Therapeutic Target by Rasanen, Kati, Sriswasdi, Sira, Valiga, Alexander, Tang, Hsin-Yao, Zhang, Gao, Perego, Michela, Somasundaram, Rajasekharan, Li, Ling, Speicher, Kaye, Klein-Szanto, Andres J., Basu, Devraj, Rustgi, Anil K., Speicher, David W., Herlyn, Meenhard

“…Epithelial-mesenchymal transition (EMT) is a key contributor in tumor progression and metastasis. EMT produces cellular heterogeneity within head and neck…”
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Myeloid-derived suppressor cells coming of age by Veglia, Filippo, Perego, Michela, Gabrilovich, Dmitry

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Myeloid-derived suppressor cells coming of age by Veglia, Filippo, Perego, Michela, Gabrilovich, Dmitry

“…Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to…”
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Melanoma Stem Cell Sphere Formation Assay by Tuccitto, Alessandra, Beretta, Valeria, Rini, Francesca, Castelli, Chiara, Perego, Michela

“…Self-renewal is the ability of cells to replicate themselves at every cell cycle. Throughout self-renewal in normal tissue homeostasis, stem cell number is…”
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LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites by Camisaschi, Chiara, Casati, Chiara, Rini, Francesca, Perego, Michela, De Filippo, Annamaria, Triebel, Frédéric, Parmiani, Giorgio, Belli, Filiberto, Rivoltini, Licia, Castelli, Chiara

“…Human natural regulatory CD4(+) T cells comprise 5-10% of peripheral CD4(+)T cells. They constitutively express the IL-2Ralpha-chain (CD25) and the nuclear…”
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NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment by Bertolini, Irene, Perego, Michela, Ghosh, Jagadish C., Kossenkov, Andrew V., Altieri, Dario C.

“…Small extracellular vesicles (sEV) contribute to the crosstalk between tumor cells and stroma, but the underlying signals are elusive. Here, we show that sEV…”
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Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy by Somasundaram, Rajasekharan, Connelly, Thomas, Choi, Robin, Choi, Hyeree, Samarkina, Anastasia, Li, Ling, Gregorio, Elizabeth, Chen, Yeqing, Thakur, Rohit, Abdel-Mohsen, Mohamed, Beqiri, Marilda, Kiernan, Meaghan, Perego, Michela, Wang, Fang, Xiao, Min, Brafford, Patricia, Yang, Xue, Xu, Xiaowei, Secreto, Anthony, Danet-Desnoyers, Gwenn, Traum, Daniel, Kaestner, Klaus H., Huang, Alexander C., Hristova, Denitsa, Wang, Joshua, Fukunaga-Kalabis, Mizuho, Krepler, Clemens, Ping-Chen, Fang, Zhou, Xiangyang, Gutierrez, Alexis, Rebecca, Vito W., Vonteddu, Prashanthi, Dotiwala, Farokh, Bala, Shashi, Majumdar, Sonali, Dweep, Harsh, Wickramasinghe, Jayamanna, Kossenkov, Andrew V., Reyes-Arbujas, Jorge, Santiago, Kenisha, Nguyen, Tran, Griss, Johannes, Keeney, Frederick, Hayden, James, Gavin, Brian J., Weiner, David, Montaner, Luis J., Liu, Qin, Peiffer, Lukas, Becker, Jürgen, Burton, Elizabeth M., Davies, Michael A., Tetzlaff, Michael T., Muthumani, Kar, Wargo, Jennifer A., Gabrilovich, Dmitry, Herlyn, Meenhard

“…Anti-PD-1 therapy is used as a front-line treatment for many cancers, but mechanistic insight into this therapy resistance is still lacking. Here we generate a…”
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Correction: NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment by Bertolini, Irene, Perego, Michela, Ghosh, Jagadish C., Kossenkov, Andrew V., Altieri, Dario C.

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Correction: NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment by Bertolini, Irene, Perego, Michela, Ghosh, Jagadish C., Kossenkov, Andrew V., Altieri, Dario C.

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Intercellular HIF1[alpha] reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions by Bertolini, Irene, Perego, Michela, Nefedova, Yulia, Lin, Cindy, Milcarek, Andrew, Vogel, Peter, Ghosh, Jagadish C, Kossenkov, Andrew V, Altieri, Dario C

“…The origin of breast cancer, whether primary or recurrent, is unknown. Here, we show that invasive breast cancer cells exposed to hypoxia release small…”
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Tumor-associated B-cells induce tumor heterogeneity and therapy resistance by Somasundaram, Rajasekharan, Zhang, Gao, Fukunaga-Kalabis, Mizuho, Perego, Michela, Krepler, Clemens, Xu, Xiaowei, Wagner, Christine, Hristova, Denitsa, Zhang, Jie, Tian, Tian, Wei, Zhi, Liu, Qin, Garg, Kanika, Griss, Johannes, Hards, Rufus, Maurer, Margarita, Hafner, Christine, Mayerhöfer, Marius, Karanikas, Georgios, Jalili, Ahmad, Bauer-Pohl, Verena, Weihsengruber, Felix, Rappersberger, Klemens, Koller, Josef, Lang, Roland, Hudgens, Courtney, Chen, Guo, Tetzlaff, Michael, Wu, Lawrence, Frederick, Dennie Tompers, Scolyer, Richard A., Long, Georgina V., Damle, Manashree, Ellingsworth, Courtney, Grinman, Leon, Choi, Harry, Gavin, Brian J., Dunagin, Margaret, Raj, Arjun, Scholler, Nathalie, Gross, Laura, Beqiri, Marilda, Bennett, Keiryn, Watson, Ian, Schaider, Helmut, Davies, Michael A., Wargo, Jennifer, Czerniecki, Brian J., Schuchter, Lynn, Herlyn, Dorothee, Flaherty, Keith, Herlyn, Meenhard, Wagner, Stephan N.

“…In melanoma, therapies with inhibitors to oncogenic BRAF V600E are highly effective but responses are often short-lived due to the emergence of drug-resistant…”
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Heterogeneity in Melanoma by Shannan, Batool, Perego, Michela, Somasundaram, Rajasekharan, Herlyn, Meenhard

“…Melanoma is among the most aggressive and therapy-resistant human cancers. While great strides in therapy have generated enthusiasm, many challenges remain…”
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Parkin activates innate immunity and promotes antitumor immune responses by Perego, Michela, Yeon, Minjeong, Agarwal, Ekta, Milcarek, Andrew T., Bertolini, Irene, Camisaschi, Chiara, Ghosh, Jagadish C., Tang, Hsin-Yao, Grandvaux, Nathalie, Ruscetti, Marcus, Kossenkov, Andrew V., Preston-Alp, Sarah, Tempera, Italo, Auslander, Noam, Altieri, Dario C.

“…The activation of innate immunity and associated interferon (IFN) signaling have been implicated in cancer, but the regulators are elusive and links to tumor…”
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