Search Results - "Peredo, Anne Gonzalez de"
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Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1
Published in Nature communications (23-01-2020)“…Immune checkpoint inhibitors (ICIs) have dramatically modified the prognosis of several advanced cancers, however many patients still do not respond to…”
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CD5, an Undercover Regulator of TCR Signaling
Published in Frontiers in immunology (07-12-2018)“…T cells are critical components of adaptive immunity. As such, their activation is regulated by the T cell receptor (TCR) that constantly scan peptides…”
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Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
Published in Nature immunology (01-11-2019)“…The activation of T cells by the T cell antigen receptor (TCR) results in the formation of signaling protein complexes (signalosomes), the composition of which…”
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Asb2α–Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development
Published in Circulation research (16-03-2018)“…RATIONALE:Heart development involves differentiation of cardiac progenitors and assembly of the contractile sarcomere apparatus of cardiomyocytes. However,…”
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A comprehensive LFQ benchmark dataset on modern day acquisition strategies in proteomics
Published in Scientific data (30-03-2022)“…In the last decade, a revolution in liquid chromatography-mass spectrometry (LC-MS) based proteomics was unfolded with the introduction of dozens of novel…”
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Urine in Clinical Proteomics
Published in Molecular & cellular proteomics (01-10-2008)“…Urine has become one of the most attractive biofluids in clinical proteomics as it can be obtained non-invasively in large quantities and is stable compared…”
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IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
Published in The Journal of clinical investigation (15-06-2022)“…Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem…”
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CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens
Published in Proceedings of the National Academy of Sciences - PNAS (09-06-2020)“…CD5 is characterized as an inhibitory coreceptor with an important regulatory role during T cell development. The molecular mechanism by which CD5 operates has…”
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Extensive Analysis of the Cytoplasmic Proteome of Human Erythrocytes Using the Peptide Ligand Library Technology and Advanced Mass Spectrometry
Published in Molecular & cellular proteomics (01-11-2008)“…The erythrocyte cytoplasmic proteome is composed of 98% hemoglobin; the remaining 2% is largely unexplored. Here we used a combinatorial library of hexameric…”
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Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation
Published in Molecular systems biology (01-07-2016)“…T‐cell receptor (TCR) signaling is essential for the function of T cells and negatively regulated by the E3 ubiquitin–protein ligases CBL and CBLB. Here, we…”
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In-depth Exploration of Cerebrospinal Fluid by Combining Peptide Ligand Library Treatment and Label-free Protein Quantification
Published in Molecular & cellular proteomics (01-05-2010)“…Cerebrospinal fluid (CSF) is the biological fluid in closest contact with the brain and thus contains proteins of neural cell origin. Hence, CSF is a…”
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Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function
Published in Molecular & cellular proteomics (01-08-2017)“…Regulatory T cells (Treg) represent a minor subpopulation of T lymphocytes that is crucial for the maintenance of immune homeostasis. Here, we present a…”
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Label-free Quantification and Shotgun Analysis of Complex Proteomes by One-dimensional SDS-PAGE/NanoLC-MS
Published in Molecular & cellular proteomics (01-08-2012)“…To perform differential studies of complex protein mixtures, strategies for reproducible and accurate quantification are needed. Here, we evaluated a…”
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mzDB: A File Format Using Multiple Indexing Strategies for the Efficient Analysis of Large LC-MS/MS and SWATH-MS Data Sets
Published in Molecular & cellular proteomics (01-03-2015)“…The analysis and management of MS data, especially those generated by data independent MS acquisition, exemplified by SWATH-MS, pose significant challenges for…”
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General Repression of RNA Polymerase III Transcription Is Triggered by Protein Phosphatase Type 2A-Mediated Dephosphorylation of Maf1
Published in Molecular cell (09-06-2006)“…We report genome-wide analyses that establish Maf1 as a general and direct repressor of yeast RNA polymerase (Pol) III transcription. Chromatin…”
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ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis
Published in Scientific data (03-12-2021)“…Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated…”
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Label-free quantitative proteomic analysis of human plasma-derived microvesicles to find protein signatures of abdominal aortic aneurysms
Published in Proteomics. Clinical applications (01-08-2014)“…Purpose To find potential biomarkers of abdominal aortic aneurysms (AAA), we performed a differential proteomic study based on human plasma‐derived…”
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Clinical implications of recent advances in proteogenomics
Published in Expert review of proteomics (01-02-2016)“…Proteogenomics, the alliance of proteomics, transcriptomics, genomics and bioinformatics, was first proposed for refining genome annotation using experimental…”
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Proline: an efficient and user-friendly software suite for large-scale proteomics
Published in Bioinformatics (01-05-2020)“…Abstract Motivation The proteomics field requires the production and publication of reliable mass spectrometry-based identification and quantification results…”
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IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
Published in Proceedings of the National Academy of Sciences - PNAS (31-01-2012)“…lnterleukin-33 (IL-33) (NF-HEV) is a chromatin-associated nuclear cytokine from the IL-1 family, which has been linked to important diseases, including asthma,…”
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