The Effect of Aspartame Administration on Oncogene and Suppressor Gene Expressions

Background: Aspartame (L-phenylalanine N-L-Î±-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours...

Full description

Saved in:

Bibliographic Details
Published in:	In vivo (Athens) Vol. 21; no. 1; p. 89
Main Authors:	Gombos, Katalin, Varjas, Tímea, Orsós, Zsuzsanna, Polyák, Eva, Peredi, Judit, Varga, Zsuzsanna, Nowrasteh, Ghodratollah, Tettinger, Antal, Mucsi, Gyula, Ember, István
Format:	Journal Article
Language:	English
Published:	Greece International Institute of Anticancer Research 01-01-2007
Subjects:	Animals Aspartame - adverse effects Female Gene Expression Regulation Genes, ras Mice Mice, Inbred Strains Organ Specificity Proto-Oncogene Proteins c-myc - biosynthesis Sweetening Agents - adverse effects Tumor Suppressor Protein p53 - biosynthesis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background: Aspartame (L-phenylalanine N-L-Î±-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene. Materials and Methods: After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs. Results: The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate: lymphoreticular organs, bone-marrow and kidney. Conclusion: Aspartame has a biological effect even at the recommended daily maximum dose.
ISSN:	0258-851X 1791-7549