Search Results - "Perdona, Elisabetta"

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists by Micheli, Fabrizio, Cremonesi, Susanna, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Cavanni, Paolo, Oliosi, Beatrice, Perdonà, Elisabetta, Sava, Anna, Zonzini, Laura, Feriani, Aldo, Braggio, Simone, Heidbreder, Christian

“…[Display omitted] A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and…”
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Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors by Rupniak, Nadia M J, Perdona, Elisabetta, Griffante, Cristiana, Cavallini, Palmina, Sava, Anna, Ricca, Daniel J, Thor, Karl B, Burgard, Edward C, Corsi, Mauro

“…A series of peptide NK2 receptor agonists was evaluated for affinity, potency, efficacy, and selectivity at human recombinant NK2 and NK1 receptors expressed…”
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Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonists by Faedo, Stefania, Perdonà, Elisabetta, Antolini, Marinella, di Fabio, Romano, Merlo Pich, Emilio, Corsi, Mauro

“…In this work the pharmacology and the receptor kinetics of the following orexin receptor antagonists SB-649868, ACT-078573, JNJ-10397049, MK-6096 and Roche-Cp…”
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Distinct receptor subtypes mediate arginine vasopressin-dependent ACTH release and intracellular calcium mobilization in rat pituitary cells by Perdonà, Elisabetta, Arban, Roberto, Griffante, Cristiana

“…In the present study, adrenocorticotropic hormone (ACTH) release and intracellular calcium ([Ca2+]i) increase induced by arginine vasopressin (AVP) were…”
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In vitro and in vivo characterization of the novel GABA B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE) by Perdona’, Elisabetta, Costantini, Vivian J.A., Tessari, Michela, Martinelli, Prisca, Carignani, Corrado, Valerio, Enzo, Mok, M.H. Selina, Zonzini, Laura, Visentini, Filippo, Gianotti, Massimo, Gordon, Laurie, Rocheville, Magalie, Corsi, Mauro, Capelli, Anna Maria

“…There is preclinical evidence supporting the finding that the GABA B receptor orthosteric agonist, baclofen, has significant effects on eating behavior…”
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonists by SABBATINI, Fabio M, DI FABIO, Romano, DENIS, Yves St, COSTA, Silvano, CORSI, Mauro, GRIFFANTE, Cristiana, PENTASSUGLIA, Giorgio, ZONZINI, Laura, MELOTTO, Sergio, ALVARO, Giuseppe, CAPELLI, Anna M, PIPPO, Lara, PERDONA, Elisabetta

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In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE) by Perdona', Elisabetta, Costantini, Vivian J A, Tessari, Michela, Martinelli, Prisca, Carignani, Corrado, Valerio, Enzo, Mok, M H Selina, Zonzini, Laura, Visentini, Filippo, Gianotti, Massimo, Gordon, Laurie, Rocheville, Magalie, Corsi, Mauro, Capelli, Anna Maria

“…There is preclinical evidence supporting the finding that the GABA(B) receptor orthosteric agonist, baclofen, has significant effects on eating behavior…”
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Azabicyclo[3.1.0]hexane-1-carbohydrazides as Potent and Selective GHSR1a Ligands Presenting a Specific in vivo Behavior by Sabbatini, Fabio Maria, Melotto, Sergio, Bernasconi, Giovanni, Bromidge, Steve M., D'Adamo, Lucilla, Rinaldi, Marilisa, Savoia, Chiara, Mundi, Claudia, Di Francesco, Carla, Zonzini, Laura, Costantini, Vivian J. A., Perini, Benedetta, Valerio, Enzo, Pozzan, Alfonso, Perdonà, Elisabetta, Visentini, Filippo, Corsi, Mauro, Di Fabio, Romano

“…Buon appetito! The synthesis and in vitro and in vivo profiles of a novel series of potent and selective ghrelin ligands is presented. Selected compounds share…”
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Discovery Process and Characterization of Novel Carbohydrazide Derivatives as Potent and Selective GHSR1a Antagonists by Sabbatini, Fabio Maria, Di Fabio, Romano, Corsi, Mauro, Cavanni, Paolo, Bromidge, Steve M., St-Denis, Yves, D'Adamo, Lucilla, Contini, Stefania, Rinaldi, Marilisa, Guery, Sebastien, Savoia, Chiara, Mundi, Claudia, Perini, Benedetta, Carpenter, Andrew J., Dal Forno, Giovanna, Faggioni, Federico, Tessari, Michela, Pavone, Francesca, Di Francesco, Carla, Buson, Alberto, Mattioli, Mario, Perdona', Elisabetta, Melotto, Sergio

“…Ghrelins: don't feed them after dark! A novel class of highly potent and selective growth hormone secretagogue receptor 1a (GHSR1a) antagonists has been…”
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1,2,4-Triazolyl 5‑Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists by Micheli, Fabrizio, Bacchi, Alessia, Braggio, Simone, Castelletti, Laura, Cavallini, Palmina, Cavanni, Paolo, Cremonesi, Susanna, Dal Cin, Michele, Feriani, Aldo, Gehanne, Sylvie, Kajbaf, Mahmud, Marchió, Luciano, Nola, Selena, Oliosi, Beatrice, Pellacani, Annalisa, Perdonà, Elisabetta, Sava, Anna, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Wong, Andrea, Visentini, Filippo, Zonzini, Laura, Heidbreder, Christian

“…A novel series of 1,2,4-triazolyl 5-azaspiro[2.4]­heptanes with high affinity and selectivity at the dopamine (DA) D3 receptor (D3R) is described. Some of…”
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Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors by Perdonà, Elisabetta, Faggioni, Federico, Buson, Alberto, Sabbatini, Fabio Maria, Corti, Corrado, Corsi, Mauro

“…A novel growth hormone secretagogues type 1a (GHS1a) receptors antagonist (2R)-N'-[3,5-…”
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Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems by Grillo, Alessandro, Chemi, Giulia, Brogi, Simone, Brindisi, Margherita, Relitti, Nicola, Fezza, Filomena, Fazio, Domenico, Castelletti, Laura, Perdona, Elisabetta, Wong, Andrea, Lamponi, Stefania, Pecorelli, Alessandra, Benedusi, Mascia, Fantacci, Manuela, Valoti, Massimo, Valacchi, Giuseppe, Micheli, Fabrizio, Novellino, Ettore, Campiani, Giuseppe, Butini, Stefania, Maccarrone, Mauro, Gemma, Sandra

“…Polypharmacology approaches may help the discovery of pharmacological tools for the study or the potential treatment of complex and multifactorial diseases as…”
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Potency, efficacy, and selectivity of GR64349 at human recombinant neurokinin NK2 and NK1 receptors by Perdona, Elisabetta, Cavallini, Palmina, Sava, Anna, Griffante, Cristiana, Ricca, Daniel J., Thor, Karl B., Rupniak, Nadia M.J., Corsi, Mauro

“…•The affinity and potency of GR64349 for NK2 and NK1 receptors was examined.•Binding affinity was ˜1200-fold higher for NK2 than NK1 receptors.•Potency was…”
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In vitro and in vivo characterization of the novel GABA sub(B receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2- p iperidinyl}ethanol (CMPPE)) by Perdona', Elisabetta, Costantini, Vivian JA, Tessari, Michela, Martinelli, Prisca, Carignani, Corrado, Valerio, Enzo, Mok, MHSelina, Zonzini, Laura, Visentini, Filippo, Gianotti, Massimo, Gordon, Laurie, Rocheville, Magalie, Corsi, Mauro, Capelli, Anna Maria

“…There is preclinical evidence supporting the finding that the GABA sub(B receptor orthosteric agonist, baclofen, has significant effects on eating behavior…”
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Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo by Heidbreder, Christian A., Bianchi, Massimiliano, Lacroix, Laurent P., Faedo, Stefania, Perdona, Elisabetta, Remelli, Rosaria, Cavanni, Paolo, Crespi, Francesco

“…The mechanisms through which blockade of metabotropic glutamate receptors 5 (mGluR5) results in anxiolytic and antidepressant effects are currently unknown. In…”
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK sub(1) receptor antagonists by Sabbatini, Fabio M, Di Fabio, Romano, Griffante, Cristiana, Pentassuglia, Giorgio, Zonzini, Laura, Melotto, Sergio, Alvaro, Giuseppe, Capelli, Anna M, Pippo, Lara, Perdona', Elisabetta, St Denis, Yves, Costa, Silvano, Corsi, Mauro

“…A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK sub(1)…”
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK 1 receptor antagonists by Sabbatini, Fabio M., Fabio, Romano Di, Griffante, Cristiana, Pentassuglia, Giorgio, Zonzini, Laura, Melotto, Sergio, Alvaro, Giuseppe, Capelli, Anna M., Pippo, Lara, Perdona’, Elisabetta, Denis, Yves St, Costa, Silvano, Corsi, Mauro

“…A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK 1 antagonists. In…”
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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists by Sabbatini, Fabio M, Di Fabio, Romano, Griffante, Cristiana, Pentassuglia, Giorgio, Zonzini, Laura, Melotto, Sergio, Alvaro, Giuseppe, Capelli, Anna M, Pippo, Lara, Perdona', Elisabetta, St Denis, Yves, Costa, Silvano, Corsi, Mauro

“…A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK(1) antagonists. In…”
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Backbone 1H, 13C and 15N resonance assignment of the N-terminal 24 kDa fragment of the gyrase B subunit from E. coli by Bellanda, Massimo, Peggion, Evaristo, Otting, Gottfried, Weigelt, Johan, Perdona, Elisabetta, Domenici, Enrico, Marchioro, Carla, Mammi, Stefano

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Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions by Sissi, Claudia, Perdonà, Elisabetta, Domenici, Enrico, Feriani, Aldo, Howells, Alison J, Maxwell, Anthony, Palumbo, Manlio

“…The conformational equilibria of the A subunit of DNA gyrase (GyrA), of its 59 kDa N-terminal fragment (GyrA59) and of the quinolone-resistant Ser-Trp83 mutant…”
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