Search Results - "Percy, A"

Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection by Knolle, Percy A, Thimme, Robert

“…The liver has unique immune regulatory functions that promote the induction of tolerance rather than responses to antigens encountered locally. These functions…”
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Immunological functions of liver sinusoidal endothelial cells by Knolle, Percy A, Wohlleber, Dirk

“…Liver sinusoidal endothelial cells (LSECs) line the liver sinusoids and separate passenger leukocytes in the sinusoidal lumen from hepatocytes. LSECs further…”
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Living in the liver: hepatic infections by Protzer, Ulrike, Maini, Mala K., Knolle, Percy A.

“…Key Points The liver serves as an important filter organ to remove circulating pathogens from the blood. However, certain pathogens — such as hepatitis B…”
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A comprehensive review on the production and enhancement techniques of gaseous biofuels and their applications in IC engines with special reference to the associated performance and emission characteristics by Percy, A. Jemila, Edwin, M.

“…The increasing global demand for energy, coupled with environmental concerns associated with fossil fuels, has led to the exploration of alternative fuel…”
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Antigen-presenting cell function in the tolerogenic liver environment by Thomson, Angus W, Knolle, Percy A

“…Key Points The liver is a solid organ with unique immunoregulatory functions that are determined by the hepatic microenvironment, which is rich in regulatory…”
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Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances by Bauernfeind, Franz, Niepmann, Sven, Knolle, Percy A, Hornung, Veit

“…Accumulating evidence suggests that the activation of the innate branch of the immune system plays a pivotal role in the induction and perpetuation of…”
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Staying local — antigen presentation in the liver by Knolle, Percy A

“…Highlights • The liver has unique immune functions. • Organ-resident cells contribute to regulation of antigen-specific immunity by functioning as…”
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TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection by Alfei, Francesca, Kanev, Kristiyan, Hofmann, Maike, Wu, Ming, Ghoneim, Hazem E., Roelli, Patrick, Utzschneider, Daniel T., von Hoesslin, Madlaina, Cullen, Jolie G., Fan, Yiping, Eisenberg, Vasyl, Wohlleber, Dirk, Steiger, Katja, Merkler, Doron, Delorenzi, Mauro, Knolle, Percy A., Cohen, Cyrille J., Thimme, Robert, Youngblood, Benjamin, Zehn, Dietmar

“…Cytotoxic T cells are essential mediators of protective immunity to viral infection and malignant tumours and are a key target of immunotherapy approaches…”
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NLRP3 inflammasome activity is negatively controlled by miR-223 by Bauernfeind, Franz, Rieger, Anna, Schildberg, Frank A, Knolle, Percy A, Schmid-Burgk, Jonathan L, Hornung, Veit

“…Inflammasomes are multiprotein signaling platforms that form upon sensing microbe- or damage-associated molecular patterns. Upon their formation, caspase-1 is…”
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Techno‐economic studies on the variable compression ratio dual fuel diesel‐producer gas CI engine utilizing different biomass feedstocks by Percy, A. Jemila, Edwin, M.

“…In this study, a techno‐economic analysis for a 3.75 kW biomass gasification power generation system (BMPGS) was conducted by exploiting available biomass…”
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Liver macrophages in healthy and diseased liver by Abdullah, Zeinab, Knolle, Percy A.

“…Kupffer cells, the largest tissue resident macrophage population, are key for the maintenance of liver integrity and its restoration after injury and…”
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An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice by Ludwig-Portugall, Isis, Bartok, Eva, Dhana, Ermanila, Evers, Beatrix D G, Primiano, Michael J, Hall, J Perry, Franklin, Bernardo S, Knolle, Percy A, Hornung, Veit, Hartmann, Gunther, Boor, Peter, Latz, Eicke, Kurts, Christian

“…Intrarenal crystal formation activates the Nlrp3 inflammasome in myeloid cells and triggers a profound inflammatory response. Here, we studied whether a…”
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mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus by Bergant, Valter, Schnepf, Daniel, de Andrade Krätzig, Niklas, Hubel, Philipp, Urban, Christian, Engleitner, Thomas, Dijkman, Ronald, Ryffel, Bernhard, Steiger, Katja, Knolle, Percy A., Kochs, Georg, Rad, Roland, Staeheli, Peter, Pichlmair, Andreas

“…Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain…”
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Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure by Zeisel, Mirjam B, Lucifora, Julie, Mason, William S, Sureau, Camille, Beck, Jürgen, Levrero, Massimo, Kann, Michael, Knolle, Percy A, Benkirane, Monsef, Durantel, David, Michel, Marie-Louise, Autran, Brigitte, Cosset, François-Loïc, Strick-Marchand, Hélène, Trépo, Christian, Kao, Jia-Horng, Carrat, Fabrice, Lacombe, Karine, Schinazi, Raymond F, Barré-Sinoussi, Françoise, Delfraissy, Jean-François, Zoulim, Fabien

“…HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and…”
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Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH by Dudek, Michael, Pfister, Dominik, Donakonda, Sainitin, Filpe, Pamela, Schneider, Annika, Laschinger, Melanie, Hartmann, Daniel, Hüser, Norbert, Meiser, Philippa, Bayerl, Felix, Inverso, Donato, Wigger, Jennifer, Sebode, Marcial, Öllinger, Rupert, Rad, Roland, Hegenbarth, Silke, Anton, Martina, Guillot, Adrien, Bowman, Andrew, Heide, Danijela, Müller, Florian, Ramadori, Pierluigi, Leone, Valentina, Garcia-Caceres, Cristina, Gruber, Tim, Seifert, Gabriel, Kabat, Agnieszka M., Mallm, Jan-Philipp, Reider, Simon, Effenberger, Maria, Roth, Susanne, Billeter, Adrian T., Müller-Stich, Beat, Pearce, Edward J., Koch-Nolte, Friedrich, Käser, Rafael, Tilg, Herbert, Thimme, Robert, Boettler, Tobias, Tacke, Frank, Dufour, Jean-Francois, Haller, Dirk, Murray, Peter J., Heeren, Ron, Zehn, Dietmar, Böttcher, Jan P., Heikenwälder, Mathias, Knolle, Percy A.

“…Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liver disease and cancer 1 , 2 . The…”
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Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice by Seubert, Bastian, Grünwald, Barbara, Kobuch, Julia, Cui, Haissi, Schelter, Florian, Schaten, Susanne, Siveke, Jens T., Lim, Ngee H., Nagase, Hideaki, Simonavicius, Nicole, Heikenwalder, Mathias, Reinheckel, Thomas, Sleeman, Jonathan P., Janssen, Klaus‐Peter, Knolle, Percy A., Krüger, Achim

“…Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)‐1 has been thought to suppress tumor…”
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Prediction on the Performance Parameters of a Variable Compression Ratio (VCR) Dual Fuel Diesel-Producer Gas CI Engine: An Experimental and Theoretical Approach by Percy, A. Jemila, Edwin, M.

“…In recent years, biomass fuelled engines have gathered major interest due to rapid depletion and rising price of conventional fuels. Biomass gasification has a…”
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Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation by Burgdorf, Sven, Kautz, Andreas, Böhnert, Volker, Knolle, Percy A, Kurts, Christian

“…The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8⁺ effector T cells (cross-presentation) or to CD4⁺…”
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Interfering with Kupffer cell replenishment: New insights into liver injury by Alazawi, William, Knolle, Percy A.

“…Knolle and Alazawi expresses insights on the study of Borst and colleagues regarding the roles of interferon (IFN) as the integral component of liver's…”
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Scaling of immune responses against intracellular bacterial infection by Abdullah, Zeinab, Knolle, Percy A

“…Macrophages detect bacterial infection through pattern recognition receptors (PRRs) localized at the cell surface, in intracellular vesicles or in the cytosol…”
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