Search Results - "Perchuk, Barrett S"

Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families by Capra, Emily J., Perchuk, Barrett S., Skerker, Jeffrey M., Laub, Michael T.

“…Orthologous proteins often harbor numerous substitutions, but whether these differences result from neutral or adaptive processes is usually unclear. To tackle…”
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A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus by Modell, Joshua W, Kambara, Tracy K, Perchuk, Barrett S, Laub, Michael T

“…Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage…”
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A Dynamic Complex of Signaling Proteins Uses Polar Localization to Regulate Cell-Fate Asymmetry in Caulobacter crescentus by Tsokos, Christos G., Perchuk, Barrett S., Laub, Michael T.

“…Cellular asymmetry is critical to metazoan development and the life cycle of many microbes. In Caulobacter, cell cycle progression and the formation of…”
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Evolving New Protein-Protein Interaction Specificity through Promiscuous Intermediates by Aakre, Christopher D., Herrou, Julien, Phung, Tuyen N., Perchuk, Barrett S., Crosson, Sean, Laub, Michael T.

“…Interacting proteins typically coevolve, and the identification of coevolving amino acids can pinpoint residues required for interaction specificity. This…”
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Regulation of the bacterial cell cycle by an integrated genetic circuit by Laub, Michael T, Biondi, Emanuele G, Reisinger, Sarah J, Skerker, Jeffrey M, Arif, Muhammad, Perchuk, Barrett S, Ryan, Kathleen R

“…How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component…”
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Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis by Skerker, Jeffrey M, Prasol, Melanie S, Perchuk, Barrett S, Biondi, Emanuele G, Laub, Michael T

“…Two-component signal transduction systems, comprised of histidine kinases and their response regulator substrates, are the predominant means by which bacteria…”
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Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways by Capra, Emily J, Perchuk, Barrett S, Lubin, Emma A, Ashenberg, Orr, Skerker, Jeffrey M, Laub, Michael T

“…Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli. Sensor histidine kinases transmit…”
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Evolving a robust signal transduction pathway from weak cross-talk by Goulian, Mark, Siryaporn, Albert, Perchuk, Barrett S, Laub, Michael T

“…We have evolved a robust two‐component signal transduction pathway from a sensor kinase (SK) and non‐partner response regulator (RR) that show weak cross‐talk…”
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Dynamics of Two Phosphorelays Controlling Cell Cycle Progression in Caulobacter crescentus by CHEN, Y. Erin, TSOKOS, Christos G, BIONDI, Emanuele G, PERCHUK, Barrett S, LAUB, Michael T

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Direct and adaptor-mediated substrate recognition by an essential AAA+ protease by Chien, Peter, Perchuk, Barrett S, Laub, Michael T, Sauer, Robert T, Baker, Tania A

“…Regulated proteolysis is required to execute many cellular programs. In Caulobacter crescentus, timely degradation of the master regulator CtrA by ClpXP…”
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Global Regulation of Gene Expression and Cell Differentiation in Caulobacter crescentus in Response to Nutrient Availability by ENGLAND, Jennifer C, PERCHUK, Barrett S, LAUB, Michael T, GOBER, James W

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Overexpression of VpsS, a Hybrid Sensor Kinase, Enhances Biofilm Formation in Vibrio cholerae by SHIKUMA, Nicholas J, FONG, Jiunn C. N, ODELL, Lindsay S, PERCHUK, Barrett S, LAUB, Michael T, YILDIZ, Fitnat H

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A phosphorelay system controls stalk biogenesis during cell cycle progression in Caulobacter crescentus by Biondi, Emanuele G., Skerker, Jeffrey M., Arif, Muhammad, Prasol, Melanie S., Perchuk, Barrett S., Laub, Michael T.

“…Summary A fundamental question in developmental biology is how morphogenesis is coordinated with cell cycle progression. In Caulobacter crescentus, each cell…”
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Rewiring the Specificity of Two-Component Signal Transduction Systems by Skerker, Jeffrey M., Perchuk, Barrett S., Siryaporn, Albert, Lubin, Emma A., Ashenberg, Orr, Goulian, Mark, Laub, Michael T.

“…Two-component signal transduction systems are the predominant means by which bacteria sense and respond to environmental stimuli. Bacteria often employ tens or…”
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Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus by Gora, Kasia G., Cantin, Amber, Wohlever, Matthew, Joshi, Kamal K., Perchuk, Barrett S., Chien, Peter, Laub, Michael T.

“…Summary Cell cycle transitions are often triggered by the proteolysis of key regulatory proteins. In Caulobacter crescentus, the G1‐S transition involves the…”
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A Cell-Type-Specific Protein-Protein Interaction Modulates Transcriptional Activity of a Master Regulator in Caulobacter crescentus by Gora, Kasia G., Tsokos, Christos G., Chen, Y. Erin, Srinivasan, Balaji S., Perchuk, Barrett S., Laub, Michael T.

“…Progression through the Caulobacter cell cycle is driven by the master regulator CtrA, an essential two-component signaling protein that regulates the…”
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Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity by Capra, Emily J., Perchuk, Barrett S., Ashenberg, Orr, Seid, Charlotte A., Snow, Hana R., Skerker, Jeffrey M., Laub, Michael T.

“…Summary Signal transduction proteins are often multi‐domain proteins that arose through the fusion of previously independent proteins. How such a change in the…”
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A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus: e1001977 by Modell, Joshua W, Kambara, Tracy K, Perchuk, Barrett S, Laub, Michael T

“…Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage…”
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Adaptive mutations that prevent cross-talk enable the expansion of paralogous signaling protein families by Capra, Emily J., Perchuk, Barrett S., Skerker, Jeffrey M., Laub, Michael T.

“…Orthologous proteins often harbor numerous substitutions, but whether these differences result from neutral or adaptive processes is usually unclear. To tackle…”
Get full text

Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in C aulobacter crescentus by Gora, Kasia G., Cantin, Amber, Wohlever, Matthew, Joshi, Kamal K., Perchuk, Barrett S., Chien, Peter, Laub, Michael T.

“…Cell cycle transitions are often triggered by the proteolysis of key regulatory proteins. In C aulobacter crescentus , the G 1‐ S transition involves the…”
Get full text