Search Results - "Perchellet, E M"

Antioxidants and multistage carcinogenesis in mouse skin by Perchellet, J P, Perchellet, E M

“…The two-step initiation-promotion protocol for the induction of skin tumors in mice is a convenient model to elucidate what molecular events are involved in…”
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Comparison of the inhibitory effects of monomeric, dimeric, and trimeric procyanidins on the biochemical markers of skin tumor promotion in mouse epidermis in vivo by Gali, H U, Perchellet, E M, Gao, X M, Karchesy, J J, Perchellet, J P

“…Several procyanidin dimers and an epicatechin trimer purified from Douglas fir bark tannins were compared with their monomer components (+)-catechin and…”
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A synthetic triptycene bisquinone, which blocks nucleoside transport and induces DNA fragmentation, retains its cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines by Wang, B, Wu, M, Perchellet, E M, McIlvain, C J, Sperfslage, B J, Huang, X, Tamura, M, Stephany, H A, Hua, D H, Perchellet, J P

“…In contrast to the parent triptycene (code name TT0), triptycene bisquinone (code name TT2) is cytostatic (IC50: 300 nM) and cytotoxic (IC50: 230 nM) in…”
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6,7,8,9-Tetrahydro-3-methyl-1H-pyrano[4,3-b]quinolin-1-one by Hua, D. H., Chen, Y., Sin, H.-S., Robinson, P. D., Meyers, C. Y., Perchellet, E. M., Perchellet, J.-P., Chiang, P. K., Biellmann, J.-F.

“…The condensation reaction of 4-amino-6-methyl-2-pyrone with 1-cyclohexenecarboxaldehyde and a catalytic amount of (S)-(+)-10-camphorsulfonic acid in toluene at…”
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Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12- O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo by Newell, S.W., Perchellet, E.M., Gao, X.M., Chen, G., Perchellet, J.P.

“…The non-12- O-tetadecanoylphorbol-13-acetate (TPA)-type tumor promoters, okadaic acid (OA) and calyculin-A (CAL-A), which neither interact with the phorbol…”
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Antitumor-promoting effects of gallotannins extracted from various sources in mouse skin in vivo by Gali, H U, Perchellet, E M, Gao, X M, Bottari, V, Perchellet, J P

“…Sumach leaf, Aleppo gall, Tara pod and commercial tannic acids (TAs) were tested topically for their ability to inhibit the biochemical and biological effects…”
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Tricyclic pyrone analogs: a new synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro and the growth of solid tumors in vivo by Perchellet, E M, Ladesich, J B, Magill, M J, Chen, Y, Hua, D H, Perchellet, J P

“…Tricyclic pyrones (TPs) may represent a novel synthetic class of microtubule (MT) de-stabilizing anticancer drugs previously shown by us to inhibit…”
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Antitumor-promoting activities of hydrolyzable tannins in mouse skin by Gali, H U, Perchellet, E M, Klish, D S, Johnson, J M, Perchellet, J P

“…Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment…”
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Antitumor activity of novel octalactin A analogs in murine leukemia cells in vitro by Perchellet, J P, Perchellet, E M, Newell, S W, Freeman, J A, Ladesich, J B, Jeong, Y, Sato, N, Buszek, K

“…Octalactin A and B (code names K1 and K2) are eight-membered-ring lactones from a marine bacterium. K1 is reportedly cytotoxic. Since access to this natural…”
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Inhibitory effects of semisynthetic flavonoid derivatives on the biochemical markers of tumor promotion in mouse epidermis in vivo by Gali, H U, Perchellet, E M, Gao, X M, Laks, P E, Perchellet, J P

“…Two sets of flavonoid derivatives were synthesized from condensed tannins (CTs) or catechin, and compared with the procyanidin monomer models, (+)-catechin and…”
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Antitumor activity of novel tricyclic pyrone analogs in murine leukemia cells in vitro by Perchellet, J P, Newell, S W, Ladesich, J B, Perchellet, E M, Chen, Y, Hua, D H, Kraft, S L, Basaraba, R J, Omura, S, Tomoda, H

“…New tricyclic pyrone derivatives were synthesized and tested for their ability to prevent L1210 leukemic cells from synthesizing DNA and growing in vitro. At…”
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Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin by PERCHELLET, J.-P, ABNEY, N. L, THOMAS, R. M, GUISLAIN, Y. L, PERCHELLET, E. M

“…Several structurally different tumor promoters altered to various degrees both glutathione (GSH) peroxidase (EC 1.11.1.9) and ornithine decarboxylase (ODC,…”
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Ability of m-chloroperoxybenzoic acid to induce the ornithine decarboxylase marker of skin tumor promotion and inhibition of this response by gallotannins, oligomeric proanthocyanidins, and their monomeric units in mouse epidermis in vivo by Chen, G, Perchellet, E M, Gao, X M, Newell, S W, Hemingway, R W, Bottari, V, Perchellet, J P

“…m-Chloroperoxybenzoic acid (CPBA) was tested for its ability to induce the ornithine decarboxylase (ODC) marker of skin tumor promotion. In contrast to benzoyl…”
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Characterization of the antitumor-promoting activity of camptothecin in SENCAR mouse skin by Gao, Xiao Mei, Perchellet, Elisabeth M., Davis, Amy W., Newell, Steven W., Hua, Duy H., Perchellet, Jean-Pierre

“…(+)-Camptothecin (CPT), a topoisomerase I inhibitor specifically toxic toward S phase cells, was tested topically for its ability to inhibit skin tumor…”
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Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate in vivo by Gali, H U, Perchellet, E M, Klish, D S, Johnson, J M, Perchellet, J P

“…The anti-oxidant and the anti-tumor-promotion activities of several hydrolyzable tannins (HTs), including a commercial tannic-acid (TA) mixture, were examined…”
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Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate by PERCHELLET, J.-P, ABNEY, N. L, THOMAS, R. M, PERCHELLET, E. M, MAATTA, E. A

“…Diethyldithiocarbamate (DDTC) injected i.p. inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione…”
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Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin by Perchellet, J P, Gali, H U, Perchellet, E M, Klish, D S, Armbrust, A D

“…Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the biochemical and biological…”
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Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate by Perchellet, E M, Maatta, E A, Abney, N L, Perchellet, J P

“…Since the enhancement of the activity of the natural glutathione (GSH)-dependent antioxidant protective system of the epidermal cells appears to inhibit the…”
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Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters by Perchellet, J P, Perchellet, E M, Orten, D K, Schneider, B A

“…Cellular pro-oxidant states appear to play role in the promotion phase, presumably because tumor promoter-treated cells overproduce activated forms of oxygen…”
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Triptycenes: a novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro by Perchellet, E M, Magill, M J, Huang, X, Brantis, C E, Hua, D H, Perchellet, J P

“…In contrast to their inactive parent compound triptycene (code name TT0), several triptycene (TT) analogs (code names TT1 to TT13), most of them new compounds,…”
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