Search Results - "Peraro, Leila"

Cell Penetration Profiling Using the Chloroalkane Penetration Assay by Peraro, Leila, Deprey, Kirsten L, Moser, Matthew K, Zou, Zhongju, Ball, Haydn L, Levine, Beth, Kritzer, Joshua A

“…Biotherapeutics are a promising class of molecules in drug discovery, but they are often limited to extracellular targets due to their poor cell penetration…”
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Emerging Methods and Design Principles for Cell‐Penetrant Peptides by Peraro, Leila, Kritzer, Joshua A.

“…Biomolecules such as antibodies, proteins, and peptides are important tools for chemical biology and leads for drug development. They have been used to inhibit…”
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Parallel Screening Using the Chloroalkane Penetration Assay Reveals Structure-Penetration Relationships by Mientkiewicz, Kaley M, Peraro, Leila, Kritzer, Joshua A

“…The efficiency with which polycationic peptides penetrate the cytosol depends on the number and overall patterning of arginine residues. While general trends…”
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Improved cytosine base editors generated from TadA variants by Lam, Dieter K., Feliciano, Patricia R., Arif, Amena, Bohnuud, Tanggis, Fernandez, Thomas P., Gehrke, Jason M., Grayson, Phil, Lee, Kin D., Ortega, Manuel A., Sawyer, Courtney, Schwaegerle, Noah D., Peraro, Leila, Young, Lauren, Lee, Seung-Joo, Ciaramella, Giuseppe, Gaudelli, Nicole M.

“…Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally…”
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Dual targeting ovarian cancer by Muc16 CAR T cells secreting a bispecific T cell engager antibody for an intracellular tumor antigen WT1 by Mun, Sung Soo, Meyerberg, Jeremy, Peraro, Leila, Korontsvit, Tatyana, Gardner, Thomas, Malviya, Manish, Kyi, Chrisann, O’Cearbhaill, Roisin E., Liu, Cheng, Dao, Tao, Scheinberg, David A.

“…Epithelial ovarian cancer is the most lethal of gynecological cancers. The therapeutic efficacy of chimeric antigen receptor (CAR) T cell directed against…”
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Incorporation of bacterial immunoevasins to protect cell therapies from host antibody-mediated immune rejection by Peraro, Leila, Bourne, Christopher M., Dacek, Megan M., Akalin, Enver, Park, Jae H., Smith, Eric L., Scheinberg, David A.

“…Cellular therapies are engineered using foreign and synthetic protein sequences, such as chimeric antigen receptors (CARs). The frequently observed humoral…”
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A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies by Klatt, Martin G., Dao, Tao, Yang, Zhiyuan, Liu, Jianying, Mun, Sung Soo, Dacek, Megan M., Luo, Hanzhi, Gardner, Thomas J., Bourne, Christopher, Peraro, Leila, Aretz, Zita E.H., Korontsvit, Tanya, Lau, Michael, Kharas, Michael G., Liu, Cheng, Scheinberg, David A.

“…Target identification for chimeric antigen receptor (CAR) T-cell therapies remains challenging due to the limited repertoire of tumor-specific surface…”
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A TCR Mimic Antibody-Directed CAR T Cell Specific for Intracellular NDC80 Is Broadly Cancer Reactive and Displays High Activity Against Hematological Malignancies by Klatt, Martin G., Yang, Zhiyuan, Liu, Jianying, Korontsvit, Tatyana, Mun, Sung Soo, Peraro, Leila, Gardner, Thomas J., Bourne, Christopher, Dacek, Megan M., Dao, Tao, Liu, Cheng, Scheinberg, David A.

“…Chimeric antigen receptor (CAR) T cells represent a novel class of FDA-approved drugs with high efficacy against refractory B cell derived malignancies and…”
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Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy by Peraro, Leila, Zou, Zhongju, Makwana, Kamlesh M, Cummings, Ashleigh E, Ball, Haydn L, Yu, Hongtao, Lin, Yu-Shan, Levine, Beth, Kritzer, Joshua A

“…Autophagy is an essential pathway by which cellular and foreign material are degraded and recycled in eukaryotic cells. Induction of autophagy is a promising…”
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The Design and Synthesis of Cell-Penetrant Autophagy-Inducing Peptides and the Development of a Novel Assay for Measuring Cell Penetration by Peraro, Leila

“…Biotherapeutics are gaining popularity as efficient modulators of protein-protein interactions. However, accessing intracellular targets remains a significant…”
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Synthesis and Biological Evaluation of a Depsipeptidic Histone Deacetylase Inhibitor via a Generalizable Approach Using an Optimized Latent Thioester Solid-Phase Linker by Zang, Xiaoyu, Peraro, Leila, Davison, Ryan T, Blum, Travis R, Vallabhaneni, Deepak, Fennell, Caitlyn E, Cramer, Stephanie L, Shah, Heli K, Wholly, Deirdre M, Fink, Elissa A, Sivak, Jacob T, Ingalls, Kathryn M, Herr, Chelsea T, Lawson, Vernon E, Burnett, Matthew R, Slade, David J, Cole, Kathryn E, Carle, Sigrid A, Miller, Justin S

“…We describe the synthesis of Xyzidepsin, a depsipeptidic analogue of HDAC inhibitor Romidepsin (FK228), using a solid-phase strategy. Our latent thioester…”
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A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake by Quartararo, Justin S., Eshelman, Matthew R., Peraro, Leila, Yu, Hongtao, Baleja, James D., Lin, Yu-Shan, Kritzer, Joshua A.

“…[Display omitted] While peptides are promising as probes and therapeutics, targeting intracellular proteins will require greater understanding of highly…”
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Testing Novel Depsipeptides for Histone Deacetylases Inhibitor Activity by Mitchell, Caitlyn, Carle, Sigrid, Enos, Stephen, Miller, Justin, Zang, Xiaoyu, Vallabhaneni, Deepak, Peraro, Leila

“…Abstract only Gene expression is partly controlled by posttranscriptional modifications to histones. These modifications either loosen the binding between…”
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Targeted Cellular Micropharmacies: Cells Engineered for Localized Drug Delivery by Gardner, Thomas J, Bourne, Christopher M, Dacek, Megan M, Kurtz, Keifer, Malviya, Manish, Peraro, Leila, Silberman, Pedro C, Vogt, Kristen C, Unti, Mildred J, Brentjens, Renier, Scheinberg, David

“…The recent emergence of engineered cellular therapies, such as Chimeric antigen receptor (CAR) CAR T and T cell receptor (TCR) engineered T cells, has shown…”
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Oral Abstract: CT-080: A Tumor-Agnostic TCR-Mimic CAR-T cell Specific for NDC80 Targets Multiple Hematological Malignancies by Klatt, Martin G., Dao, Tao, Yang, Zhiyuan, Liu, Jianying, Mun, Sung Soo, Dacek, Megan M., Luo, Hanzhi, Gardner, Thomas J., Bourne, Christopher, Peraro, Leila, Aretz, Zita E.H., Korontsvit, Tanya, Kharas, Michael G., Liu, Cheng, Scheinberg, David A.

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Poster: CT-080: A Tumor-Agnostic TCR-Mimic CAR-T cell Specific for NDC80 Targets Multiple Hematological Malignancies by Klatt, Martin G., Dao, Tao, Yang, Zhiyuan, Liu, Jianying, Mun, Sung Soo, Dacek, Megan M., Luo, Hanzhi, Gardner, Thomas J., Bourne, Christopher, Peraro, Leila, Aretz, Zita E.H., Korontsvit, Tanya, Kharas, Michael G., Liu, Cheng, Scheinberg, David A.

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CT-080: A Tumor-Agnostic TCR-Mimic CAR-T cell Specific for NDC80 Targets Multiple Hematological Malignancies by Klatt, Martin G., Dao, Tao, Yang, Zhiyuan, Liu, Jianying, Mun, Sung Soo, Dacek, Megan M., Luo, Hanzhi, Gardner, Thomas J., Bourne, Christopher, Peraro, Leila, Aretz, Zita E.H., Korontsvit, Tanya, Kharas, Michael G., Liu, Cheng, Scheinberg, David A.

“…Target identification for CAR-T cell therapies, especially shared targets among different malignancies, remains challenging due to the limited repertoire of…”
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Neue Methoden und Designprinzipien für zellgängige Peptide by Peraro, Leila, Kritzer, Joshua A.

“…Biomoleküle, wie Antikörper, Proteine und Peptide, sind wichtige Werkzeuge in der chemischen Biologie und Ansatzpunkte für die Wirkstoffentwicklung. Sie wurden…”
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