Search Results - "Perahia, D"

ABCG2/BCRP transport mechanism revealed through kinetically excited targeted molecular dynamics simulations by Dudas, B., Decleves, X., Cisternino, S., Perahia, D., Miteva, M.A.

“…[Display omitted] ABCG2/BCRP is an ABC transporter that plays an important role in tissue protection by exporting endogenous substrates and xenobiotics. ABCG2…”
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Effect of phosphorylation on the structural dynamics, thermal stability of human dopamine transporter: A simulation study using normal modes, molecular dynamics and Markov State Model by Quiroz, R.C.N., Philot, E.A., General, I.J., Perahia, D., Scott, A.L.

“…The Human Dopamine Transporter (hDAT) plays an essential role in modulating the Influx/Efflux of dopamine, and it is involved in the mechanism of certain…”
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Duloxetine in the treatment of major depressive disorder: a placebo- and paroxetine-controlled trial by Perahia, D.G.S., Wang, F., Mallinckrodt, C.H., Walker, D.J., Detke, M.J.

“…Duloxetine doses of 80 and 120 mg/day were assessed for efficacy and safety in the treatment of major depressive disorder (MDD). In this randomized,…”
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Unveiling mutation effects on the structural dynamics of the main protease from SARS-CoV-2 with hybrid simulation methods by Gasparini, P., Philot, E.A., Pantaleão, S.Q., Torres-Bonfim, N.E.S.M., Kliousoff, A., Quiroz, R.C.N., Perahia, D., Simões, R.P., Magro, A.J., Scott, A.L.

“…The main protease of SARS-CoV-2 (called Mpro or 3CLpro) is essential for processing polyproteins encoded by viral RNA. Several Mpro mutations were found in…”
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Presence and predictors of pain in depression: Results from the FINDER study by Demyttenaere, K, Reed, C, Quail, D, Bauer, M, Dantchev, N, Montejo, A.L, Monz, B, Perahia, D, Tylee, A, Grassi, L

“…Abstract Background Patients with depression often experience pain. There is limited understanding of the relation between pain and other symptoms (depressive,…”
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Treatment and outcomes for patients with depression who are partial responders to SSRI treatment: Post-hoc analysis findings from the FINDER European observational study by Lenox-Smith, A, Martinez, J.M, Perahia, D, Dowsett, S.A, Dennehy, E.B, Lopez-Romero, P, Demyttenaere, K

“…Abstract Background Remission is the goal in depression, but in practice many patients only experience a partial response to treatment. We sought to determine…”
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25 New insights on nucleic acids - protein interfaces revealed by VLDM, a geometrical approach by Elbahnsi, A., Mauffret, O., Perahia, D., Hartmann, B., Oguey, C.

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Transport and Structural Studies of Sulfonated Styrene−Ethylene Copolymer Membranes by Serpico, J. M, Ehrenberg, S. G, Fontanella, J. J, Jiao, X, Perahia, D, McGrady, K. A, Sanders, E. H, Kellogg, G. E, Wnek, G. E

“…The structure and proton conductivity of sulfonated styrene−ethylene copolymers have been studied. Conductivities in excess of 0.1 S/cm are obtained depending…”
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Spreading of liquid droplets on permeable polymeric surfaces by Pierce, F, Perahia, D, Grest, G. S

“…The spreading of liquid droplets on viscous liquid and glassy polymer films has been studied with molecular dynamics simulations. Unlike spreading on solid…”
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Duloxetine 60 mg/day for the prevention of depressive recurrences: post hoc analyses from a recurrence prevention study by Kelin, K, Berk, M, Spann, M, Sagman, D, Raskin, J, Walker, D, Perahia, D

“…To assess the efficacy of duloxetine 60 mg/day in the prevention of depressive recurrence in patients with major depressive disorder (MDD). Patients having at…”
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Duloxetine 60 mg once daily in the treatment of milder major depressive disorder by Perahia, D G S, Kajdasz, D K, Walker, D J, Raskin, J, Tylee, A

“…There is ongoing debate regarding the effectiveness of antidepressants in patients with milder major depressive disorder (MDD). This post-hoc analysis…”
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Internal and interfacial dielectric properties of cytochrome c from molecular dynamics in aqueous solution by Simonson, T. (Centre National de la Recherche Scientifique, Illkirch, France), Perahia, D

“…The dielectric properties of proteins are central to their stability and activity. We use the Frohlich-Kirkwood theory of dielectrics to analyze two 1-ns…”
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Efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder: a pooled analysis of four randomized, double-blind, placebo-controlled studies by Davidson, Jonathan, Allgulander, Christer, Pollack, Mark H., Hartford, James, Erickson, Janelle S., Russell, James M., Perahia, David, Wohlreich, Madalaine M., Carlson, Janice, Raskin, Joel

“…Objective To assess the efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder (GAD). Methods Acute‐phase data from a…”
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P.2.c.023 Switching to duloxetine from SSRI non- and partial-responders: does the type of SSRI prior to switch influence outcomes? by Perahia, D, Quail, D, Desaiah, D, Gilaberte, I, Haddad, P

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Conformational dynamics and enzyme activity by Yon, J.M., Perahia, D., Ghélis, C.

“…Conformational flexibility and structural fluctuations play an important role in enzyme activity. A great variety of internal motions ranging over different…”
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Bulk and Interfacial Studies of a New and Versatile Semifluorinated Lyotropic Liquid Crystalline Polymer by Traiphol, R, Shah, H, Smith, D. W, Perahia, D

“…This study introduces the phase diagram and interfacial characteristics of a novel lyotropic polymeric liquid crystal. The polymer consists of an…”
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Perfluorocyclobutyl Liquid Crystalline Fluoropolymers. Synthesis and Thermal Cyclopolymerization of Bis(trifluorovinyloxy)-α-methylstilbene by Smith, D. W, Boone, H. W, Traiphol, R, Shah, H, Perahia, D

“…The cyclopolymerization of aromatic trifluorovinyl ether (TFVE) monomers has been established as a versatile route to a unique class of linear and network…”
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P.2.c.028 Duloxetine hepatic effects: 2006 review by Perahia, D, Acharya, N, Wang, F, Strombom, I, D'Souza, D, Wernicke, J

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Atomic force microscopy studies on the dewetting of perfluorinated ionomer thin films by Hill, T. A., Carroll, D. L., Czerw, R., Martin, C. W., Perahia, D.

“…The surface structure and dewetting process of thin films of complex perfluorinated ion‐containing polymers have been studied with atomic force microscopy…”
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Birefringence detection of the order-to-disorder transition in block copolymer liquids by Balsara, N. P, Perahia, D, Safinya, C. R, Tirrell, M, Lodge, T. P

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