Search Results - "Peracoli, Jose Carlos"
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How can we reduce maternal mortality due to preeclampsia? The 4P rule
Published in Revista Brasileira de ginecologia e obstetrícia (01-01-2024)“…In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of…”
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Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia
Published in Molecules (Basel, Switzerland) (19-04-2019)“…Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether…”
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Letter to the editor: FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth
Published in International journal of gynecology and obstetrics (01-10-2022)Get full text
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Potential role of uric acid to activate NLRP3 inflammasome triggering endothelial dysfunction in preeclampsia
Published in Clinical immunology communications (01-12-2022)“…Preeclampsia (PE) is a pregnancy-related disorder associated with increasing maternal death rates and affecting 2–8% of pregnant women worldwide. Arterial…”
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Inflammasomes in placental explants of women with preeclampsia cultured with monosodium urate may be modulated by vitamin D
Published in Hypertension in pregnancy (03-04-2022)“…Preeclampsia (PE) is an important syndrome of gestation characterized by placental and systemic inflammation. High plasma concentration of uric acid are…”
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Association between Adverse Maternal Clinical Outcomes and Imbalance of Cytokines and Angiogenic Factors in Preterm Preeclampsia
Published in Revista Brasileira de ginecologia e obstetrícia (01-09-2021)“…Preeclampsia (PE) is a pregnancy-specific syndrome characterized by abnormal levels of cytokines and angiogenic factors, playing a role in the disease…”
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Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia
Published in PloS one (08-06-2015)“…Preeclampsia (PE) is a specific syndrome of pregnancy, characterized by hypertension and proteinuria. This pathology is associated with hyperuricemia and…”
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Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre‐eclampsia
Published in International journal of gynecology and obstetrics (01-05-2023)“…Objective To assess and compare circulating tissue inhibitor of metalloproteinase 3 (TIMP‐3) concentrations between women with pre‐eclampsia and healthy…”
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Increase of autophagy marker p62 in the placenta from pregnant women with preeclampsia
Published in Human immunology (01-05-2022)“…Preeclampsia (PE) is a multisystemic disorder characterized by abnormal placentation. Autophagy is a lysosomal degradation pathway that removes protein…”
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Immunomodulatory effect of vitamin D on the STATs and transcription factors of CD4+ T cell subsets in pregnant women with preeclampsia
Published in Clinical immunology (Orlando, Fla.) (01-01-2022)“…This study evaluated the in vitro modulatory effect of vitamin D (VD) on T cells, by determining the expression of STATs and the transcription factors of each…”
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DAMPs are able to skew CD4+ T cell subsets and increase the inflammatory profile in pregnant women with preeclampsia
Published in Journal of reproductive immunology (01-02-2022)“…•Sterile inflammation is up-regulated by the presence of DAMPs in preeclampsia.•DAMPs stimulation can contribute to the activation of the adaptive immunity in…”
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Vitamin D modulates the transcription factors of T cell subsets to anti-inflammatory and regulatory profiles in preeclampsia
Published in International immunopharmacology (01-12-2021)“…[Display omitted] •Vitamin D downregulatesthe sterile inflammation in preeclampsia.•Pregnant women with preeclampsia have lower plasmatic levels of…”
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Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells
Published in Hypertension in pregnancy (03-04-2021)“…Objective: To investigate whether the supernatant from monocytes of preeclamptic and normotensive pregnant women, cultured in vitro with silibinin, can…”
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Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia
Published in Journal of reproductive immunology (01-04-2021)“…Graphical abstract showing the immunomodulatory effect of progesterone (PG) and vitamin D (VD) on the inflammatory state of monocytes from preeclamptic women…”
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Silibinin downregulates the expression of the Th1 and Th17 profiles by modulation of STATs and transcription factors in pregnant women with preeclampsia
Published in International immunopharmacology (01-08-2022)“…•Silibinin downregulates the Th1 and Th17 profiles in preeclampsia.•Silibinin upregulates the anti-inflammatory and regulatory profiles.•Immunomodulatory role…”
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COVID‐19: A new risk factor or just a new imitator of preeclampsia? NLRP3 activation: A possible common mechanism
Published in Journal of medical virology (01-05-2022)Get full text
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Vitamin D decreases expression of NLRP1 and NLRP3 inflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide
Published in Human immunology (01-01-2022)“…This study aimed to evaluate the immunomodulatory effect of vitamin D (VD) on the NLRP1 and NLRP3 inflammasomes in placental explants from preeclamptic (PE)…”
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Vitamin D decreases cell death and inflammation in human umbilical vein endothelial cells and placental explants from pregnant women with preeclampsia cultured with TNF-α
Published in Immunological investigations (18-08-2022)“…This study evaluated the impact of vitamin D on Human Umbilical Vein Endothelial Cells (HUVEC) and inflammation in placental explants from women with…”
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Elevated circulating adenosine deaminase activity in women with preeclampsia: association with pro-inflammatory cytokine production and uric acid levels
Published in Pregnancy hypertension (01-10-2016)“…Highlights • ADA activity and hyperuricemia were highly correlated in preeclampsia. • ADA activity may be involved in inflammatory activation of peripheral…”
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