Search Results - "Perálvarez‐Marín, Alex"

Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel by Berna-Erro, Alejandro, Izquierdo-Serra, Mercè, Sepúlveda, Romina V., Rubio-Moscardo, Fanny, Doñate-Macián, Pau, Serra, Selma A., Carrillo-Garcia, Julia, Perálvarez-Marín, Alex, González-Nilo, Fernando, Fernández-Fernández, José M., Valverde, Miguel A.

“…TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major…”
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Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity by Guivernau, Biuse, Bonet, Jaume, Valls-Comamala, Victòria, Bosch-Morató, Mònica, Godoy, Juan A, Inestrosa, Nibaldo C, Perálvarez-Marín, Alex, Fernández-Busquets, Xavier, Andreu, David, Oliva, Baldomero, Muñoz, Francisco J

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can…”
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A TRPV2 interactome-based signature for prognosis in glioblastoma patients by Doñate-Macián, Pau, Gómez, Antonio, Dégano, Irene R, Perálvarez-Marín, Alex

“…Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and…”
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Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold by Catalina-Hernández, Èric, López-Martín, Mario, Masnou-Sánchez, David, Martins, Marco, Lorenz-Fonfria, Victor A, Jiménez-Altayó, Francesc, Hellmich, Ute A, Inada, Hitoshi, Alcaraz, Antonio, Furutani, Yuji, Nonell-Canals, Alfons, Vázquez-Ibar, Jose Luis, Domene, Carmen, Gaudet, Rachelle, Perálvarez-Marín, Alex

“…TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and…”
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Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1 by Ondono, Raul, Lirio, Ángel, Elvira, Carlos, Álvarez-Marimon, Elena, Provenzano, Claudia, Cardinali, Beatrice, Pérez-Alonso, Manuel, Perálvarez-Marín, Alex, Borrell, José I., Falcone, Germana, Estrada-Tejedor, Roger

“…[Display omitted] •Drug design with rational methods, using structure-based methods.•Novel RNA binders based on pyrido[2,3-d]pyrimidin-7-(8H)-ones.•Myotonic…”
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Transcriptional response to metal starvation in the emerging pathogen Mycoplasma genitalium is mediated by Fur-dependent and -independent regulatory pathways by Martínez-Torró, Carlos, Torres-Puig, Sergi, Monge, Marta, Sánchez-Alba, Lucía, González-Martín, Miguel, Marcos-Silva, Marina, Perálvarez-Marín, Alex, Canals, Francesc, Querol, Enrique, Piñol, Jaume, Pich, Oscar Q.

“…Transition metals participate in numerous enzymatic reactions and they are essential for survival in all living organisms. For this reason, bacterial pathogens…”
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Probing a polar cluster in the retinal binding pocket of bacteriorhodopsin by a chemical design approach by Simón-Vázquez, Rosana, Domínguez, Marta, Lórenz-Fonfría, Víctor A, Alvarez, Susana, Bourdelande, José-Luís, de Lera, Angel R, Padrós, Esteve, Perálvarez-Marín, Alex

“…Bacteriorhodopsin has a polar cluster of amino acids surrounding the retinal molecule, which is responsible for light harvesting to fuel proton pumping. From…”
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Time-Resolved Infrared Spectroscopy of pH-Induced Aggregation of the Alzheimer Aβ1–28 Peptide by Perálvarez-Marín, Alex, Barth, Andreas, Gräslund, Astrid

“…Aggregation of the Alzheimer's disease-related Aβ1–28 peptide was induced by a rapid, sub-millisecond pH jump and monitored by time-resolved infrared…”
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Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity by Gallego-Villarejo, Lucía, Wallin, Cecilia, Król, Sylwia, Enrich-Bengoa, Jennifer, Suades, Albert, Aguilella-Arzo, Marcel, Gomara, María José, Haro, Isabel, Wärmlander, Sebastian, Muñoz, Francisco J., Gräslund, Astrid, Perálvarez-Marín, Alex

“…[Display omitted] Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce…”
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What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? by Perálvarez‐Marín, Alex, Doñate‐Macian, Pau, Gaudet, Rachelle

“…Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by…”
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Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data by Enrich-Bengoa, Jennifer, Manich, Gemma, Dégano, Irene R, Perálvarez-Marín, Alex

“…Demyelinating disorders show impaired remyelination due to failure in the differentiation of oligodendrocyte progenitor cells (OPCs) into mature myelin-forming…”
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Thr-90 Plays a Vital Role in the Structure and Function of Bacteriorhodopsin by Perálvarez-Marín, Alex, Márquez, Mercedes, Bourdelande, José-Luis, Querol, Enric, Padrós, Esteve

“…The role of Thr-90 in the bacteriorhodopsin structure and function was investigated by its replacement with Ala and Val. The mutant D115A was also studied…”
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TRPV2: A Key Player in Myelination Disorders of the Central Nervous System by Enrich-Bengoa, Jennifer, Manich, Gemma, Valente, Tony, Sanchez-Molina, Paula, Almolda, Beatriz, Solà, Carme, Saura, Josep, González, Berta, Castellano, Bernardo, Perálvarez-Marín, Alex

“…Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some…”
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Roadmap for Postnatal Brain Maturation: Changes in Gray and White Matter Composition during Development Measured by Fourier Transformed Infrared Microspectroscopy by Peris, Marta, Benseny-Cases, Núria, Manich, Gemma, Zerpa, Oriana, Almolda, Beatriz, Perálvarez-Marín, Àlex, González, Berta, Castellano, Bernardo

“…Key events in postnatal brain development, such as neuronal migration, synaptogenesis, and myelination, shape the adult brain. These events are reflected in…”
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Optogenetics Comes of Age: Novel Inhibitory Light-Gated Anionic Channels Allow Efficient Silencing of Neural Function by Peralvárez-Marín, Alex, Garriga, Pere

“…Optogenetics, the developing field of research that uses light‐switchable biochemical tools in a sophisticated technological approach to monitor or control…”
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Dissecting domain-specific evolutionary pressure profiles of transient receptor potential vanilloid subfamily members 1 to 4 by Doñate-Macián, Pau, Perálvarez-Marín, Alex

“…The transient receptor potential vanilloid family includes four ion channels-TRPV1, TRPV2, TRPV3 and TRPV4-that are represented within the vertebrate subphylum…”
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Secondary structure conversions of Alzheimer's Aβ(1-40) peptide induced by membrane-mimicking detergents by Wahlström, Anna, Hugonin, Loïc, Perálvarez-Marín, Alex, Jarvet, Jüri, Gräslund, Astrid

“…The amyloid β peptide (Aβ) with 39-42 residues is the major component of amyloid plaques found in brains of Alzheimer's disease patients, and soluble…”
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Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris by Suades, Albert, Alcaraz, Antonio, Cruz, Esteban, Álvarez-Marimon, Elena, Whitelegge, Julian P., Manyosa, Joan, Cladera, Josep, Perálvarez-Marín, Alex

“…Heterologous expression of human membrane proteins is a challenge in structural biology towards drug discovery. Here we report a complete expression and…”
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Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases by Loch, Rolf Antonie, Wang, Hongzhi, Perálvarez-Marín, Alex, Berger, Philipp, Nielsen, Henrietta, Chroni, Angeliki, Luo, Jinghui

“…Three common Apolipoprotein E isoforms, ApoE2, ApoE3, and ApoE4, are key regulators of lipid homeostasis, among other functions. Apolipoprotein E can interact…”
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ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit by Lamy, Anaïs, Macarini-Bruzaferro, Ewerton, Dieudonné, Thibaud, Perálvarez-Marín, Alex, Lenoir, Guillaume, Montigny, Cédric, le Maire, Marc, Vázquez-Ibar, José Luis

“…Gene targeting approaches have demonstrated the essential role for the malaria parasite of membrane transport proteins involved in lipid transport and in the…”
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