Search Results - "Pepper, Henry P."

A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis by Miles, Zachary D., Diethelm, Stefan, Pepper, Henry P., Huang, David M., George, Jonathan H., Moore, Bradley S.

“…Bacterial meroterpenoids constitute an important class of natural products with diverse biological properties and therapeutic potential. The biosynthetic logic…”
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Total Enzyme Syntheses of Napyradiomycins A1 and B1 by McKinnie, Shaun M. K, Miles, Zachary D, Jordan, Peter A, Awakawa, Takayoshi, Pepper, Henry P, Murray, Lauren A. M, George, Jonathan H, Moore, Bradley S

“…The biosynthetic route to the napyradiomycin family of bacterial meroterpenoids has been fully described 32 years following their original isolation and 11…”
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Biomimetic Total Synthesis of (±)-Merochlorin A by Pepper, Henry P., George, Jonathan H.

“…Inspired: The proposed biosynthetic pathway toward the potent antibiotic meroterpenoid (±)‐merochlorin A inspired its concise total synthesis. The key steps in…”
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Biomimetic Total Synthesis of (±)-Doitunggarcinone A and (+)-Garcibracteatone by Pepper, Henry P, Tulip, Stephen J, Nakano, Yuji, George, Jonathan H

“…A full account of our oxidative radical cyclization approach to the synthesis of garcibracteatone and doitunggarcinone A is presented. This includes the first…”
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Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products by Murray, Lauren A. M., McKinnie, Shaun M. K., Pepper, Henry P., Erni, Reto, Miles, Zachary D., Cruickshank, Michelle C., López‐Pérez, Borja, Moore, Bradley S., George, Jonathan H.

“…The naphterpins and marinones are naphthoquinone meroterpenoids with an unusual aromatic oxidation pattern that is biosynthesized from…”
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Biomimetic Total Synthesis of (±)-Garcibracteatone by Pepper, Henry P, Lam, Hiu C, Bloch, Witold M, George, Jonathan H

“…The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy…”
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Synthesis of a Liphagal–Frondosin C Hybrid and Speculation on the Biosynthesis of the Frondosins by Pepper, Henry P, Kuan, Kevin K. W, George, Jonathan H

“…A hypothesis for the biosynthesis of the frondosins A–E is presented. Synthesis of a liphagal–frondosin C hybrid molecule has been achieved, with the frondosin…”
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ortho-Quinone Methide Cyclizations Inspired by the Busseihydroquinone Family of Natural Products by Burchill, Laura, Pepper, Henry P, Sumby, Christopher J, George, Jonathan H

“…A series of cascade reactions of o-quinone methides have been developed based on the proposed biosynthesis of busseihydroquinone and parvinaphthol…”
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Biomimetic Total Synthesis of (±)‐Verrubenzospirolactone by Lam, Hiu C., Pepper, Henry P., Sumby, Christopher J., George, Jonathan H.

“…A five‐step total synthesis of (±)‐verrubenzospirolactone has been achieved using a biomimetic, intramolecular Diels–Alder reaction of a 2H‐chromene to form…”
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Total Synthesis of (+)-Aureol by Kuan, Kevin K. W, Pepper, Henry P, Bloch, Witold M, George, Jonathan H

“…A total synthesis of the marine sponge meroterpenoid (+)-aureol has been achieved in 12 steps (6% overall yield) from (+)-sclareolide. Key steps of the…”
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Biosynthetically Guided Structure–Activity Relationship Studies of Merochlorin A, an Antibiotic Marine Natural Product by López‐Pérez, Borja, Pepper, Henry P., Ma, Rong, Fawcett, Benjamin J., Pehere, Ashok D., Wei, Qi, Ji, Zengchun, Polyak, Steven W., Dai, Huanqin, Song, Fuhang, Abell, Andrew D., Zhang, Lixin, George, Jonathan H.

“…The onset of new multidrug‐resistant strains of bacteria demands continuous development of antibacterial agents with new chemical scaffolds and mechanisms of…”
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Biosynthetically Guided Structure-Activity Relationship Studies of MerochlorinA, an Antibiotic Marine Natural Product by Lopez-Perez, Borja, Pepper, Henry P, Ma, Rong, Fawcett, Benjamin J, Pehere, Ashok D, Wei, Qi, Ji, Zengchun, Polyak, Steven W, Dai, Huanqin, Song, Fuhang, Abell, Andrew D, Zhang, Lixin, George, Jonathan H

“…The onset of new multidrug-resistant strains of bacteria demands continuous development of antibacterial agents with new chemical scaffolds and mechanisms of…”
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Biomimetic Total Synthesis of (±)‐Verrubenzospirolactone by Lam, Hiu C., Pepper, Henry P., Sumby, Christopher J., George, Jonathan H.

“…A five‐step total synthesis of (±)‐verrubenzospirolactone has been achieved using a biomimetic, intramolecular Diels–Alder reaction of a 2H‐chromene to form…”
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Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products by Murray, Lauren A. M., McKinnie, Shaun M. K., Pepper, Henry P., Erni, Reto, Miles, Zachary D., Cruickshank, Michelle C., López‐Pérez, Borja, Moore, Bradley S., George, Jonathan H.

“…The naphterpins and marinones are naphthoquinone meroterpenoids with an unusual aromatic oxidation pattern that is biosynthesized from…”
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Biomimetic Total Synthesis of (±)-Merochlorin A by Pepper, Henry P., George, Jonathan H.

“…Inspiriert: Die vorgeschlagene biosynthetische Route zum antibiotischen Meroterpenoid (±)‐Merochlorin A diente als Inspiration für seine Totalsynthese…”
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Biomimetic Total Synthesis of (±)-MerochlorinA by Pepper, Henry P, George, Jonathan H

“…Inspired: The proposed biosynthetic pathway toward the potent antibiotic meroterpenoid (±)-merochlorinA inspired its concise total synthesis. The key steps in…”
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Biomimetic Total Synthesis of (±)-MerochlorinA by Pepper, Henry P, George, Jonathan H

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