Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

ABSTRACT Background and objective Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Me...

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Published in:	Respirology (Carlton, Vic.) Vol. 23; no. 12; pp. 1180 - 1189
Main Authors:	Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U, Barbé, F, Bonsignore, MR, Basoglu, OK, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Grote, L, Hedner, J, Hein, H, Joppa, P, Kvamme, JA, Levy, P, Lombardi, C, Marrone, O, Masa, JF, McNicholas, WT, Montserrat, JM, Parati, G, Pataka, A, Penzel, T, Pépin, JL, Plywaczewski, R, Pretl, M, Riha, RL, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Pepin, JL, Petiet, Erna, Tasbakan, MS, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-12-2018 Wiley Subscription Services, Inc
Subjects:	Apnea Cardiovascular diseases Cholesterol Dyslipidemia Geographical distribution High density lipoprotein Hyperlipidemia hypoxia Lipids Low density lipoprotein Lungmedicin och allergi obesity Oxygen Respiratory diseases Respiratory Medicine and Allergy Risk factors Sleep Sleep apnea sleep apnoea Sleep disorders Triglycerides hypoxia cholesterol sleep apnoea dyslipidemia obesity
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Summary:	ABSTRACT Background and objective Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods The cross‐sectional analysis included 8592 patients without physician‐diagnosed hyperlipidaemia or reported intake of a lipid‐lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL‐C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL‐C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion OSA severity was independently associated with cholesterol and TG concentrations. The present study examines the association of obstructive sleep apnoea (OSA) and dyslipidaemia in the large multicentre European Sleep Apnea Database cohort. There was an independent relationship between OSA severity and lipid concentrations which was influenced by geographical region and measures of central obesity. See related Editorial
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1323-7799 1440-1843 1440-1843
DOI:	10.1111/resp.13372