Search Results - "Peoples, Aaron"

A new antibiotic kills pathogens without detectable resistance by Ling, Losee L., Schneider, Tanja, Peoples, Aaron J., Spoering, Amy L., Engels, Ina, Conlon, Brian P., Mueller, Anna, Schäberle, Till F., Hughes, Dallas E., Epstein, Slava, Jones, Michael, Lazarides, Linos, Steadman, Victoria A., Cohen, Douglas R., Felix, Cintia R., Fetterman, K. Ashley, Millett, William P., Nitti, Anthony G., Zullo, Ashley M., Chen, Chao, Lewis, Kim

“…Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were…”
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An antibiotic from an uncultured bacterium binds to an immutable target by Shukla, Rhythm, Peoples, Aaron J., Ludwig, Kevin C., Maity, Sourav, Derks, Maik G.N., De Benedetti, Stefania, Krueger, Annika M., Vermeulen, Bram J.A., Harbig, Theresa, Lavore, Francesca, Kumar, Raj, Honorato, Rodrigo V., Grein, Fabian, Nieselt, Kay, Liu, Yangping, Bonvin, Alexandre M.J.J., Baldus, Marc, Kubitscheck, Ulrich, Breukink, Eefjan, Achorn, Catherine, Nitti, Anthony, Schwalen, Christopher J., Spoering, Amy L., Ling, Losee Lucy, Hughes, Dallas, Lelli, Moreno, Roos, Wouter H., Lewis, Kim, Schneider, Tanja, Weingarth, Markus

“…Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the discovery of clovibactin, an antibiotic isolated from uncultured soil…”
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Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin by Wirtz, Daniel A., Ludwig, Kevin C., Arts, Melina, Marx, Carina E., Krannich, Sebastian, Barac, Paul, Kehraus, Stefan, Josten, Michaele, Henrichfreise, Beate, Müller, Anna, König, Gabriele M., Peoples, Aaron J., Nitti, Anthony, Spoering, Amy L., Ling, Losee L., Lewis, Kim, Crüsemann, Max, Schneider, Tanja

“…Hypeptin is a cyclodepsipeptide antibiotic produced by Lysobacter sp. K5869, isolated from an environmental sample by the iChip technology, dedicated to the…”
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Structural studies suggest aggregation as one of the modes of action for teixobactin by Öster, Carl, Walkowiak, Grzegorz P, Hughes, Dallas E, Spoering, Amy L, Peoples, Aaron J, Catherwood, Anita C, Tod, Julie A, Lloyd, Adrian J, Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G, Lewandowski, Józef R

“…Teixobactin is a new promising antibiotic that targets cell wall biosynthesis by binding to lipid II and has no detectable resistance thanks to its unique but…”
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Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin by Jagdev, Manas K., Tompa, Dharma R., Ling, Losee L., Peoples, Aaron J., Dandapat, Jagneshwar, Mohapatra, Chinmayee, Lewis, Kim, Vasudevan, Dileep

“…Antibiotics form our frontline therapy against disease-causing bacteria. Unfortunately, antibiotic resistance is becoming more common, threatening a future…”
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Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29 by Krumberger, Maj, Li, Xingyue, Kreutzer, Adam G., Peoples, Aaron J., Nitti, Anthony G., Cunningham, Andrew M., Jones, Chelsea R., Achorn, Catherine, Ling, Losee L., Hughes, Dallas E., Nowick, James S.

“…This paper describes the synthesis and stereochemical determination of Novo29 (clovibactin), a new peptide antibiotic that is related to teixobactin and is…”
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Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis by Quigley, Jeffrey, Peoples, Aaron, Sarybaeva, Asel, Hughes, Dallas, Ghiglieri, Meghan, Achorn, Catherine, Desrosiers, Alysha, Felix, Cintia, Liang, Libang, Malveira, Stephanie, Millett, William, Nitti, Anthony, Tran, Baldwin, Zullo, Ashley, Anklin, Clemens, Spoering, Amy, Ling, Losee Lucy, Lewis, Kim

“…, which causes tuberculosis (TB), is estimated to infect one-third of the world's population. The overall burden and the emergence of drug-resistant strains of…”
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Erratum: A new antibiotic kills pathogens without detectable resistance by Ling, Losee L., Schneider, Tanja, Peoples, Aaron J., Spoering, Amy L., Engels, Ina, Conlon, Brian P., Mueller, Anna, Schäberle, Till F., Hughes, Dallas E., Epstein, Slava, Jones, Michael, Lazarides, Linos, Steadman, Victoria A., Cohen, Douglas R., Felix, Cintia R., Fetterman, K. Ashley, Millett, William P., Nitti, Anthony G., Zullo, Ashley M., Chen, Chao, Lewis, Kim

“…Nature 517, 455–459 (2015); doi:10.1038/nature14098 In Fig. 3d of this Article, the ‘2:1’ and ‘1:1’ labels at the bottom of the panel were inadvertently…”
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Teixobactin kills bacteria by a two-pronged attack on the cell envelope by Shukla, Rhythm, Lavore, Francesca, Maity, Sourav, Derks, Maik G. N., Jones, Chelsea R., Vermeulen, Bram J. A., Melcrová, Adéla, Morris, Michael A., Becker, Lea Marie, Wang, Xiaoqi, Kumar, Raj, Medeiros-Silva, João, van Beekveld, Roy A. M., Bonvin, Alexandre M. J. J., Lorent, Joseph H., Lelli, Moreno, Nowick, James S., MacGillavry, Harold D., Peoples, Aaron J., Spoering, Amy L., Ling, Losee L., Hughes, Dallas E., Roos, Wouter H., Breukink, Eefjan, Lewis, Kim, Weingarth, Markus

“…Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance 1 – 3 . Teixobactin 4 represents a new class of antibiotics with a unique…”
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Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin by Wirtz, Daniel A., Ludwig, Kevin C., Arts, Melina, Marx, Carina E., Krannich, Sebastian, Barac, Paul, Kehraus, Stefan, Josten, Michaele, Henrichfreise, Beate, Müller, Anna, König, Gabriele M., Peoples, Aaron J., Nitti, Anthony, Spoering, Amy L., Ling, Losee L., Lewis, Kim, Crüsemann, Max, Schneider, Tanja

“…Hypeptin is a cyclodepsipeptide antibiotic produced by Lysobacter sp. K5869, isolated from an environmental sample by the iChip technology, dedicated to the…”
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Neocitreamicins I and II, Novel Antibiotics with Activity against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci by Peoples, Aaron J, Zhang, Qibo, Millett, William P, Rothfeder, Mithra T, Pescatore, Brian C, Madden, Anne A, Ling, Losee L, Moore, Charles M

“…Two novel antibiotics, neocitreamicins I and II, were isolated from a fermentation broth of a Nocardia strain. This producing strain was obtained using an in…”
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Diacid Linkers That Promote Parallel β-Sheet Secondary Structure in Water by Freire, Felix, Fisk, John D, Peoples, Aaron J, Ivancic, Monika, Guzei, Ilia A, Gellman, Samuel H

“…We report the development of diacid units that promote formation of a two-stranded parallel β-sheet secondary structure between peptide segments attached via…”
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Modulation of myoblast fusion by caveolin-3 in dystrophic skeletal muscle cells: implications for Duchenne muscular dystrophy and limb-girdle muscular dystrophy-1C by Volonte, Daniela, Peoples, Aaron J, Galbiati, Ferruccio

“…Caveolae are vesicular invaginations of the plasma membrane. Caveolin-3 is the principal structural component of caveolae in skeletal muscle cells in vivo. We…”
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Thermodynamic Analysis of β-Sheet Secondary Structure by Backbone Thioester Exchange by Hadley, Erik B, Witek, Alex M, Freire, Felix, Peoples, Aaron J, Gellman, Samuel H

“…No need for references: The conformational stability of β hairpins has been examined by replacing a backbone amide group by a thioester (see picture). The…”
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2 by Gavrish, Ekaterina, Sit, Clarissa S, Cao, Shugeng, Kandror, Olga, Spoering, Amy, Peoples, Aaron, Ling, Losee, Fetterman, Ashley, Hughes, Dallas, Bissell, Anthony, Torrey, Heather, Akopian, Tatos, Mueller, Andreas, Epstein, Slava, Goldberg, Alfred, Clardy, Jon, Lewis, Kim

“…Languishing antibiotic discovery and flourishing antibiotic resistance have prompted the development of alternative untapped sources for antibiotic discovery,…”
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Isofuranonaphthoquinone Produced by an Actinoplanes Isolate by Zhang, Qibo, Peoples, Aaron J, Rothfeder, Mithra T, Millett, William P, Pescatore, Brian C, Ling, Losee L, Moore, Charles M

“…A new isofuranonaphthoquinone, 7,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, was isolated from cultures of an Actinoplanes isolate obtained using an in…”
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Reducing the Bottleneck in Discovery of Novel Antibiotics by Jones, Marcus B., Nierman, William C., Shan, Yue, Frank, Bryan C., Spoering, Amy, Ling, Losee, Peoples, Aaron, Zullo, Ashley, Lewis, Kim, Nelson, Karen E.

“…Most antibiotics were discovered by screening soil actinomycetes, but the efficiency of the discovery platform collapsed in the 1960s. By now, more than 3000…”
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Structural studies suggest aggregation as one of the modes of action for teixobactinElectronic supplementary information (ESI) available: Additional figures. NMR titration data. FRET assays. NMR spectra. NMR relaxation data. PDB of the structure of teixobactin in DPC micelles. See DOI: 10.1039/c8sc03655a by Öster, Carl, Walkowiak, Grzegorz P, Hughes, Dallas E, Spoering, Amy L, Peoples, Aaron J, Catherwood, Anita C, Tod, Julie A, Lloyd, Adrian J, Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G, Lewandowski, Józef R

“…Teixobactin is a new promising antibiotic that targets cell wall biosynthesis by binding to lipid II and has no detectable resistance thanks to its unique but…”
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Structural studies suggest aggregation as one of the modes of action for teixobactin† †Electronic supplementary information (ESI) available: Additional figures. NMR titration data. FRET assays. NMR spectra. NMR relaxation data. PDB of the structure of teixobactin in DPC micelles. See DOI: 10.1039/c8sc03655a by Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G., Lewandowski, Józef R.

“…Combination of solution and solid state NMR yields a molecular level view of the interactions between antibiotic teixobactin and bacterial cell wall building…”
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Thermodynamic Analysis of β-Sheet Secondary Structure by Backbone Thioester Exchange by Hadley, Erik B., Witek, Alex M., Freire, Felix, Peoples, Aaron J., Gellman, Samuel H.

“…Kein Vergleich nötig: Die konformative Stabilität von β‐Haarnadelstrukturen beim Austausch einer Amidgruppe im Rückgrat gegen einen Thioester wurde untersucht…”
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