Antioxidant properties of 3-oxypyridine analogues: mexidol, emoxipin, proxipin

Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin-hydrogen peroxide-luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride-luminol) the antioxidant activity and mechanism of antioxidant actio...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 47; no. 3; p. 288
Main Authors:	Klebanov, G I, Liubitskiĭ, O B, Vasil'eva, O V, Klimov, Iu V, Penzulaeva, O B, Tepliashin, A S, Tolstykh, M P, Promorenko, V K, Vladimirov, Iu A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2001
Subjects:	Antioxidants - chemistry Antioxidants - metabolism Iron - metabolism Lipid Peroxidation Picolines - chemistry Picolines - metabolism Pyridines - chemistry Pyridines - metabolism Reactive Oxygen Species
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Summary:	Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin-hydrogen peroxide-luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride-luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidol > emoxipin > proxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds.
ISSN:	0042-8809