Search Results - "Penzien, Joseph B"

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents by McAllister, Laura A., Montgomery, Justin I., Abramite, Joseph A., Reilly, Usa, Brown, Matthew F., Chen, Jinshan M., Barham, Rose A., Che, Ye, Chung, Seung Won, Menard, Carol A., Mitton-Fry, Mark, Mullins, Lisa M., Noe, Mark C., O’Donnell, John P., Oliver, Robert M., Penzien, Joseph B., Plummer, Mark, Price, Loren M., Shanmugasundaram, Veerabahu, Tomaras, Andrew P., Uccello, Daniel P.

“…The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC…”
Get full text

Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols by Flanagan, Mark E, Brickner, Steven J, Lall, Manjinder, Casavant, Jeffrey, Deschenes, Laura, Finegan, Steven M, George, David M, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Hoang, Thuy, Lamb, Lucinda, Marra, Andrea, Mitton-Fry, Mark, Mueller, John P, Mullins, Lisa M, Noe, Mark C, O'Donnell, John P, Pattavina, David, Penzien, Joseph B, Schuff, Brandon P, Sun, Jianmin, Whipple, David A, Young, Jennifer, Gootz, Thomas D

“…A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along…”
Get full text

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections by Magee, Thomas V, Ripp, Sharon L, Li, Bryan, Buzon, Richard A, Chupak, Lou, Dougherty, Thomas J, Finegan, Steven M, Girard, Dennis, Hagen, Anne E, Falcone, Michael J, Farley, Kathleen A, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Kamicker, Barbara J, Kaneko, Takushi, Knickerbocker, Michael J, Liras, Jennifer L, Marra, Andrea, Medina, Ivy, Nguyen, Thuy-Trinh, Noe, Mark C, Obach, R. Scott, O’Donnell, John P, Penzien, Joseph B, Reilly, Usa Datta, Schafer, John R, Shen, Yue, Stone, Gregory G, Strelevitz, Timothy J, Sun, Jianmin, Tait-Kamradt, Amelia, Vaz, Alfin D. N, Whipple, David A, Widlicka, Daniel W, Wishka, Donn G, Wolkowski, Joanna P, Flanagan, Mark E

“…Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1)…”
Get full text