Search Results - "Penttilä, K E"

Entacapone, a novel catechol- O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production by Nissinen, Erkki, Kaheinen, Petri, Penttilä, Kai E, Kaivola, Juha, Lindén, Inge-Britt

“…Entacapone, a novel mainly peripherally acting catechol- O-methyltransferase inhibitor used in the treatment of Parkinson's disease, was evaluated for its…”
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Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes by Lindros, K O, Penttilä, K E

“…Intact rat liver cells from the perivenous region were isolated by collagenase perfusion after first destroying the periportal region by a brief portal…”
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Role of cysteine and taurine in regulating glutathione synthesis by periportal and perivenous hepatocytes by Penttilaa, K

“…The uptake and metabolism of 35S-labelled sulphur amino acids were compared in periportal (PP) and perivenous (PV) rat hepatocytes, isolated by…”
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Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver by Ingelman-Sundberg, M, Johansson, I, Penttilä, K E, Glaumann, H, Lindros, K O

“…Western blot analysis of digitonin eluates as well as immunohistochemical analysis revealed a 30-fold higher concentration of cytochrome P-450IIE1 in the…”
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Role of ethanol-inducible cytochrome P-450 IIE1 in carbon tetrachloride-induced damage to centrilobular hepatocytes from ethanol-treated rats by Lindros, K O, Cai, Y A, Penttilä, K E

“…The ethanol-inducible form of cytochrome P-450 (IIE1) is expressed and induced by ethanol, predominantly in the centrilobular region. Because this isoenzyme…”
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Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes by Kera, Y, Penttilä, K E, Lindros, K O

“…The zonal distribution of GSH metabolism was investigated by comparing hepatocytes obtained from the periportal (zone 1) or perivenous (zone 3) region by…”
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Urea synthesis in freshly isolated and in cultured periportal and perivenous hepatocytes by Pösö, A R, Penttilä, K E, Suolinna, E M, Lindros, K O

“…Periportal hepatocytes isolated by digitonin/collagenase perfusion produced urea faster than did similarly prepared perivenous hepatocytes, in both the…”
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Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes by Kera, Y, Sippel, H W, Penttilä, K E, Lindros, K O

“…The acinar distribution of glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase…”
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Depletion of hepatic glutathione by ethanol occurs independently of ethanol metabolism by Speisky, H, Kera, Y, Penttilä, K E, Israel, Y, Lindros, K O

“…The mechanism of ethanol-induced depletion of hepatic glutathione (GSH) was studied in vivo and in isolated hepatocytes. Neither inhibition of ethanol…”
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The gamma-glutamyltransferase/glutamine synthetase activity ratio. A powerful marker for the acinar origin of hepatocytes by Lindros, K O, Penttilä, K E, Gaasbeek Janzen, J W, Moorman, A F, Speisky, H, Israel, Y

“…The activity of glutamine synthetase (GS) in hepatocytes isolated by digitonin-collagenase perfusion from the perivenous region was more than 10-times higher…”
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Zonation of total and plasma protein turnover in rat liver: effects of chronic ethanol treatment by Pösö, A R, Penttilä, K E, Lindros, K O

“…To study the acinar distribution of protein turnover, rats were given a tracer dose of 14C-valine intraperitoneally. At 30 min or 20 hr later, livers were…”
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Heterogenous zonal distribution of lysosomal enzymes in rat liver by Pösö, A R, Penttilä, K E, Lindros, K O

“…The activities of beta-N-acetylglucosaminidase, beta-glucuronidase, alpha-L-iduronidase and acid phosphatase were all significantly higher in the cell lysates…”
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Effect of phenobarbital on the distribution of drug metabolizing enzymes between periportal and perivenous rat hepatocytes prepared by digitonin-collagenase liver perfusion by Bengtsson, G, Julkunen, A, Penttilä, K E, Lindros, K O

“…Intact periportal (pp) or perivenous (pv) hepatocytes were prepared by digitonin-collagenase liver perfusion. The degree of separation was indicated by…”
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Drug metabolism by periportal and perivenous rat hepatocytes. Comparison of phase I and phase II reactions and their inducibility during culture by Suolinna, E M, Penttilä, K E, Winell, B M, Sjöholm, A C, Lindros, K O

“…Hepatocytes were aseptically isolated from either the periportal (pp; zone 1) or the perivenous (pv; zone 3) region by digitonin-collagenase perfusion and…”
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Glutathione metabolism in isolated rat hepatocytes: acinar heterogeneity of detoxifying enzymes and effects of ethanol by Kera, Y, Speisky, H, Penttilä, K E, Sippel, H, Lindros, K O

“…Periportal and perivenous hepatocytes were isolated by the digitonin-collagenase perfusion technique. The activity of the cytosolic glutathione S-transferase…”
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Ribosomal ribonucleases in avian liver during estrogen-induced vitellogenin synthesis by Penttilä, K E, Mäenpää, P H

“…The ribonuclease activity associated with rooster liver ribosomes decreases and the endogenous ribosomal RNAase inhibitor becomes undetectable during…”
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Allyl alcohol cytotoxicity and glutathione depletion in isolated periportal and perivenous rat hepatocytes by Penttilä, K E

“…The mechanism of the periportal (p.p.) toxicity of allyl alcohol (AlOH) was investigated in p.p. and perivenous (p.v.) hepatocytes isolated by…”
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Regioselective induction of liver glutathione transferase by ethanol and acetone by Sippel, H, Penttila, K E, Lindros, K O

“…Both ethanol and acetone are substrates and inducers of the cytochrome P450 IIEI. This isoenzyme is induced in the perivenous region, which may explain the…”
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Allyl alcohol liver injury: suppression by ethanol and relation to transient glutathione depletion by Penttilä, K E, Mäkinen, J, Lindros, K O

“…Rats metabolized a sublethal gastric dose (0.73 mmol/kg) of allyl alcohol (AIOH) within 10-15 min. Oxidation of AIOH to acrolein was accompanied by an equally…”
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Effects of entacapone and tolcapone on mitochondrial membrane potential by Haasio, Kristiina, Koponen, Anita, Penttilä, Kai E, Nissinen, Erkki

“…Catechol- O-methyl transferase (COMT) inhibitors, entacapone and tolcapone, are used as an adjunctive treatment to l-dopa in Parkinson's disease. Based on…”
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