Search Results - "Penta, Kalyani"

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System by Zimmerman, Erik S, Heibeck, Tyler H, Gill, Avinash, Li, Xiaofan, Murray, Christopher J, Madlansacay, Mary Rose, Tran, Cuong, Uter, Nathan T, Yin, Gang, Rivers, Patrick J, Yam, Alice Y, Wang, Willie D, Steiner, Alexander R, Bajad, Sunil U, Penta, Kalyani, Yang, Wenjin, Hallam, Trevor J, Thanos, Christopher D, Sato, Aaron K

“…Antibody–drug conjugates (ADCs) are a targeted chemotherapeutic currently at the cutting edge of oncology medicine. These hybrid molecules consist of a tumor…”
Get full text

Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system by Yin, Gang, Garces, Eudean D., Yang, Junhao, Zhang, Juan, Tran, Cuong, Steiner, Alexander R, Roos, Christine, Bajad, Sunil, Hudak, Susan, Penta, Kalyani, Zawada, James, Pollitt, Sonia, Murray, Christopher J.

“…We describe protein synthesis, folding and assembly of antibody fragments and full-length aglycosylated antibodies using an Escherichia coli-based open…”
Get full text

RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates by Yin, Gang, Stephenson, Heather T., Yang, Junhao, Li, Xiaofan, Armstrong, Stephanie M., Heibeck, Tyler H., Tran, Cuong, Masikat, Mary Rose, Zhou, Sihong, Stafford, Ryan L., Yam, Alice Y., Lee, John, Steiner, Alexander R., Gill, Avinash, Penta, Kalyani, Pollitt, Sonia, Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., McEvoy, Leslie M., Sato, Aaron K., Hallam, Trevor J.

“…Amber codon suppression for the insertion of non-natural amino acids (nnAAs) is limited by competition with release factor 1 (RF1). Here we describe the genome…”
Get full text

Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1 by Zhong, Jingping, Eliceiri, Brian, Stupack, Dwayne, Penta, Kalyani, Sakamoto, Gordon, Quertermous, Thomas, Coleman, Mike, Boudreau, Nancy, Varner, Judith A

“…The ECM protein Del-1 is one of several novel ECM proteins that accumulate around angiogenic blood vessels in embryonic and tumor tissue and promote…”
Get full text

Cloning of an Immunoglobulin Family Adhesion Molecule Selectively Expressed by Endothelial Cells by Hirata, Ken-ichi, Ishida, Tatsuro, Penta, Kalyani, Rezaee, Mehrdad, Yang, Eugene, Wohlgemuth, Jay, Quertermous, Thomas

“…To gain fundamental information regarding the molecular basis of endothelial cell adhesive interactions during vascular formation, we have cloned and…”
Get full text

Erythropoietin Induces the Tyrosine Phosphorylation, Nuclear Translocation, and DNA Binding of STAT1 and STAT5 in Erythroid Cells (∗) by Penta, Kalyani, Sawyer, Stephen T.

“…We have investigated whether Signal Transducing and Activators of Transcription (STAT) proteins become activated following the binding of erythropoietin (EPO)…”
Get full text

Distinct Signaling from Stem Cell Factor and Erythropoietin in HCD57 Cells by Jacobs-Helber, Sarah M., Penta, Kalyani, Sun, Zhenhong, Lawson, Amy, Sawyer, Stephen T.

“…A recent report (Wu, H., Klingmuller, U., Besmer, P., and Lodish, H. F. (1995) Nature 377, 242-246) documents the interaction of the erythropoietin (EPO)…”
Get full text

Methods to Make Homogenous Antibody Drug Conjugates by Kline, Toni, Steiner, Alexander R., Penta, Kalyani, Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Antibody drug conjugates (ADCs) have progressed from hypothesis to approved therapeutics in less than 30 years, and the technologies available to modify both…”
Get full text

Abstract 2781: De novo molecular mechanisms of resistance to mobocertinib by Vincent, Sylvie, Su, Zhenqiang, Joshi, Adarsh, Penta, Kalyani, Zhang, Pingkuan

“…Abstract Mobocertinib is an oral tyrosine kinase inhibitor recently approved by the FDA for the treatment of patients (pts) with locally advanced or metastatic…”
Get full text

Association of JAK2 and STAT5 with Erythropoietin Receptors by Sawyer, Stephen T., Penta, Kalyani

“…Cytokine receptors act at least partially by associating with Janus tyrosine protein kinases at the conserved box one motif of the receptor. These…”
Get full text

In vitro Fab display: a cell-free system for IgG discovery by Stafford, Ryan L., Matsumoto, Marissa L., Yin, Gang, Cai, Qi, Fung, Juan Jose, Stephenson, Heather, Gill, Avinash, You, Monica, Lin, Shwu-Hwa, Wang, Willie D., Masikat, Mary Rose, Li, Xiaofan, Penta, Kalyani, Steiner, Alex R., Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., Hallam, Trevor J., Sato, Aaron K.

“…Selection technologies such as ribosome display enable the rapid discovery of novel antibody fragments entirely in vitro. It has been assumed that the open…”
Get full text

Del1 Induces Integrin Signaling and Angiogenesis by Ligation of αVβ3 by Penta, Kalyani, Varner, Judith A., Liaw, Lucy, Hidai, Chiaki, Schatzman, Randy, Quertermous, Thomas

Get full text

Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1 by Zhong, Jingping, Eliceiri, Brian, Stupack, Dwayne, Penta, Kalyani, Sakamoto, Gordon, Quertermous, Thomas, Coleman, Mike, Boudreau, Nancy, Varner, Judith A.

“…The ECM protein Del-1 is one of several novel ECM proteins that accumulate around angiogenic blood vessels in embryonic and tumor tissue and promote…”
Get full text

Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ3 integrin receptor by Hidai, Chiaki, Zupancic, Thomas, Penta, Kalyani, Mikhail, Adel, Kawana, Masatoshi, Quertermous, Elena E., Aoka, Yoshikazu, Fukagawa, Masafumi, Matsui, Yasuhisa, Platika, Doros, Auerbach, Robert, Hogan, Brigid L.M., Snodgrass, Ralph, Quertermous, Thomas

“…We have taken advantage of an enhancer trap event in a line of transgenic mice to identify a unique developmentally regulated endothelial cell locus ( Del1 )…”
Get full text

Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells) by Bao, Haifeng, Jacobs-Helber, Sarah M., Lawson, Amy E., Penta, Kalyani, Wickrema, Amittha, Sawyer, Stephen T.

“…We found that erythropoietin (EPO) and stem cell factor (SCF) activated protein kinase B (PKB/Akt) in EPO-dependent HCD57 erythroid cells. To better understand…”
Get full text

The Embryonic Angiogenic Factor Del1 Accelerates Tumor Growth by Enhancing Vascular Formation by Aoka, Yoshikazu, Johnson, Frances L., Penta, Kalyani, Hirata, Ken-ichi, Hidai, Chiaki, Schatzman, Randall, Varner, Judith A., Quertermous, Thomas

“…Del1 is a unique αvβ3 integrin ligand that is produced by endothelial cells, and thus provides an autocrine signaling pathway in this cell type. It is…”
Get full text

Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3) by Rezaee, Mehrdad, Penta, Kalyani, Quertermous, Thomas

“…Del1 is a matrix protein transiently expressed by embryonic endothelial cells. It was recently demonstrated that vascular endothelial cells adhere and interact…”
Get more information

Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction by Sawyer, S T, Penta, K

“…Cytokine receptors act at least partially by associating with Janus tyrosine protein kinases at the conserved box one motif of the receptor. These…”
Get full text

Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia by Kown, Murray H, Suzuki, Takeshi, Koransky, Mark L, Penta, Kalyani, Sakamoto, Gordon, Jahncke, Christina L, Carter, Andrew J, Quertermous, Thomas, Robbins, Robert C

“…This study compared the angiogenic effects of developmental endothelial locus-1 (DEL-1), vascular endothelial growth factor (VEGF), as well as the negative…”
Get full text

Del1 Induces Integrin Signaling and Angiogenesis by Ligation of αVβ3 by Kalyani Penta, Judith A. Varner, Lucy Liaw, Chiaki Hidai, Randy Schatzman, Thomas Quertermous

“…Del1 is a novel extracellular matrix protein encoding three Notch-like epidermal growth factor repeats, an RGD motif, and two discoidin domains. Del1 is…”
Get full text