Search Results - "Pentón, David"

Functional characterization of sticholysin I and W111C mutant reveals the sequence of the actinoporin's pore assembly by Antonini, Valeria, Pérez-Barzaga, Victor, Bampi, Silvia, Pentón, David, Martínez, Diana, Dalla Serra, Mauro, Tejuca, Mayra

“…The use of pore-forming toxins in the construction of immunotoxins against tumour cells is an alternative for cancer therapy. In this protein family one of the…”
Get full text

Amplification of hydrological model uncertainties in projected climate simulations of the Upper Indus Basin: Does it matter where the water is coming from? by Dolk, Michaela, Penton, David J., Ahmad, Mobin D.

“…There is a growing appreciation of the uncertainties in the estimation of snow‐melt and glacier‐melt as a result of climate change in high elevation…”
Get full text

Validation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins by Pentón, David, Pérez-Barzaga, Victor, Díaz, Iscel, Reytor, Mey L., Campos, Javier, Fando, Rafael, Calvo, Loany, Cilli, Eduardo M., Morera, Vivian, Castellanos-Serra, Lila R., Pazos, Fabiola, Lanio, María E., Álvarez, Carlos, Pons, Tirso, Tejuca, Mayra

“…The use of pore-forming toxins from sea anemones (actinoporins) in the construction of immunotoxins (ITs) against tumour cells is an alternative for cancer…”
Get full text

Extracellular K+ rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl−‐dependent and independent mechanisms by Penton, David, Czogalla, Jan, Wengi, Agnieszka, Himmerkus, Nina, Loffing‐Cueni, Dominique, Carrel, Monique, Rajaram, Renuga Devi, Staub, Olivier, Bleich, Markus, Schweda, Frank, Loffing, Johannes

“…Key points High dietary potassium (K+) intake dephosphorylates and inactivates the NaCl cotransporter (NCC) in the renal distal convoluted tubule (DCT). Using…”
Get full text

Spatial GR4J conceptualization of the Tamor glaciated alpine catchment in Eastern Nepal: evaluation of GR4JSG against streamflow and MODIS snow extent by Nepal, Santosh, Chen, Jie, Penton, David J., Neumann, Luis E., Zheng, Hongxing, Wahid, Shahriar

“…Snow and glacial melt processes are an important part of the Himalayan water balance. Correct quantification of melt runoff processes is necessary to…”
Get full text

Characterisation of meteorological drought at sub-catchment scale in Afghanistan using station-observed climate data by Chen, Yun, Penton, David, Karim, Fazlul, Aryal, Santosh, Wahid, Shahriar, Taylor, Peter, Cuddy, Susan M

“…Droughts have severely affected Afghanistan over the last four decades, leading to critical food shortages where two-thirds of the country's population are in…”
Get full text

Model peptides mimic the structure and function of the N-terminus of the pore-forming toxin sticholysin II by Casallanovo, Fábio, de Oliveira, Felipe J. F., de Souza, Fernando C., Ros, Uris, Martínez, Yohanka, Pentón, David, Tejuca, Mayra, Martínez, Diana, Pazos, Fabiola, Pertinhez, Thelma A., Spisni, Alberto, Cilli, Eduardo M., Lanio, María E., Alvarez, Carlos, Schreier, Shirley

“…To investigate the role of the N‐terminal region in the lytic mechanism of the pore‐forming toxin sticholysin II (St II), we studied the conformational and…”
Get full text

Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter by Penton, David, Moser, Sandra, Wengi, Agnieszka, Czogalla, Jan, Rosenbaek, Lena Lindtoft, Rigendinger, Fritz, Faresse, Nourdine, Martins, Joana R, Fenton, Robert A, Loffing-Cueni, Dominique, Loffing, Johannes

“…A number of cAMP-elevating hormones stimulate phosphorylation (and hence activity) of the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT)…”
Get full text

The floodplain inundation history of the Murray-Darling Basin through two-monthly maximum water depth maps by Penton, David J., Teng, Jin, Ticehurst, Catherine, Marvanek, Steve, Freebairn, Andrew, Mateo, Cherry, Vaze, Jai, Yang, Ang, Khanam, Fathaha, Sengupta, Ashmita, Pollino, Carmel

“…With growing concerns over water management in rivers worldwide, researchers are seeking innovative solutions to monitor and understand changing flood…”
Get full text

KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function by Reichold, Markus, Zdebik, Anselm A., Lieberer, Evelyn, Rapedius, Markus, Schmidt, Katharina, Bandulik, Sascha, Sterner, Christina, Tegtmeier, Ines, Penton, David, Baukrowitz, Thomas, Hulton, Sally-Anne, Witzgall, Ralph, Ben-Zeev, Bruria, Howie, Alexander J., Kleta, Robert, Bockenhauer, Detlef, Warth, Richard, Giebisch, Gerhard

“…Mutations of the KCNJ10 (Kir4.1) K⁺ channel underlie autosomal recessive epilepsy, ataxia, sensorineural deafness, and (a salt-wasting) renal tubulopathy…”
Get full text

Water access and household economic insecurity: conceptual framework and econometric analysis applied to rural Nepal by Fleming-Muñoz, David A., Foran, Tira, Neupane, Nilhari, Rasul, Golam, Wahid, Shahriar M., Penton, David J.

“…We develop a conceptual framework to understand linkages between water access and livelihood outcomes. We apply the framework to assess factors altering the…”
Get full text

Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure by Fan, Zheng, Karakone, Mara, Nagarajan, Shunmugam, Nagy, Nadine, Mildenberger, Wiebke, Petrova, Ekaterina, Hinte, Laura Catharina, Bijnen, Mitchell, Häne, Philipp, Nelius, Eric, Chen, Jing, Ferapontova, Irina, von Meyenn, Ferdinand, Trepiccione, Francesco, Berber, Mesut, Ribas, David Penton, Eichmann, Anne, Zennaro, Maria-Christina, Takeda, Norihiko, Fischer, Jens W., Spyroglou, Ariadni, Reincke, Martin, Beuschlein, Felix, Loffing, Johannes, Greter, Melanie, Stockmann, Christian

“…Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in…”
Get full text

Large scale water yield assessment for sparsely monitored river basins: A case study for Afghanistan by Karim, Fazlul, Penton, David J., Aryal, Santosh K., Wahid, Shahriar, Chen, Yun, Taylor, Peter, Cuddy, Susan M.

“…This paper presents results from a study on water yield assessment across five major river basins of Afghanistan. The study was conducted using GR4J and GR4JSG…”
Get full text

A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma by Sigala, Sandra, Bothou, Christina, Penton, David, Abate, Andrea, Peitzsch, Mirko, Cosentini, Deborah, Tiberio, Guido A M, Bornstein, Stefan R, Berruti, Alfredo, Hantel, Constanze

“…Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. In this study, we have…”
Get full text

Task3 Potassium Channel Gene Invalidation Causes Low Renin and Salt-Sensitive Arterial Hypertension by Penton, David, Bandulik, Sascha, Schweda, Frank, Haubs, Sophia, Tauber, Philipp, Reichold, Markus, Cong, Lu Dang, El Wakil, Abeer, Budde, Thomas, Lesage, Florian, Lalli, Enzo, Zennaro, Maria-Christina, Warth, Richard, Barhanin, Jacques

“…Task1 and Task3 potassium channels (Task: tandem of P domains in a weak inward rectifying K+ channel-related acid-sensitive K+ channel) are believed to control…”
Get full text

Calcineurin regulates aldosterone production via dephosphorylation of NFATC4 by Berber, Mesut, Leng, Sining, Wengi, Agnieszka, Winter, Denise V, Odermatt, Alex, Beuschlein, Felix, Loffing, Johannes, Breault, David T, Penton, David

“…The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure…”
Get full text

Correction: Sigala et al. A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma. Cells 2022, 11, 1439 by Sigala, Sandra, Bothou, Christina, Penton, David, Abate, Andrea, Peitzsch, Mirko, Cosentini, Deborah, Tiberio, Guido A. M., Bornstein, Stefan R., Berruti, Alfredo, Hantel, Constanze

“…The authors made the following changes to their paper [...]…”
Get full text

Piezo1-dependent regulation of urinary osmolarity by Martins, Joana Raquel, Penton, David, Peyronnet, Rémi, Arhatte, Malika, Moro, Céline, Picard, Nicolas, Kurt, Birgül, Patel, Amanda, Honoré, Eric, Demolombe, Sophie

Get full text

The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron by Spirli, Alessia, Cheval, Lydie, Debonneville, Anne, Penton, David, Ronzaud, Caroline, Maillard, Marc, Doucet, Alain, Loffing, Johannes, Staub, Olivier

“…The mineralocorticoid hormone aldosterone plays a crucial role in the control of Na+ and K+ balance, blood volume, and arterial blood pressure, by acting in…”
Get full text

Calcineurin inhibitors and the renin–angiotensin–aldosterone system by Berber, Mesut, Penton, David

“…Calcineurin inhibitors (CnIs) are effective immunosuppressants with decades of accumulated experience in treating immune disorders and, most notably, solid…”
Get full text