Vasorelaxant activity of 7-β-O-glycosides biosynthesized from flavonoids

In this work we report the vasorelaxant activity of 7-β-O-glycosides obtained with biosynthesis of naringenin-7-β-O-glycoside (3) and quercetin-7-β-O-glycoside (4). These compounds were obtained from naringenin (1) and quercetin (2) glycosylation catalyzed by Beauveria bassiana ATCC 7159. Screening...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of pharmacology Vol. 733; pp. 75 - 80
Main Authors:	Penso, Juliana, Cordeiro, Kelly C.F.A, da Cunha, Carla R.M., da Silva Castro, Patricia F., Martins, Daniella R., Lião, Luciano M., Rocha, Matheus L., de Oliveira, Valéria
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-06-2014
Subjects:	Animals Aorta - drug effects Aorta relaxation Beauveria - metabolism Beauveria bassiana Biocatalysis Flavanones - biosynthesis Flavanones - chemistry Flavanones - metabolism Flavanones - pharmacology Flavonoids - chemistry Flavonoids - metabolism Glucosides - biosynthesis Glucosides - chemistry Glucosides - pharmacology Glycosylation In Vitro Techniques Male Molecular Structure Naringenin Quercetin Quercetin - analogs & derivatives Quercetin - biosynthesis Quercetin - chemistry Quercetin - isolation & purification Quercetin - metabolism Quercetin - pharmacology Rats, Wistar Vasodilation - drug effects Vasodilator Agents - isolation & purification Vasodilator Agents - pharmacology Beauveria bassiana Glycosylation Naringenin Aorta relaxation Quercetin
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In this work we report the vasorelaxant activity of 7-β-O-glycosides obtained with biosynthesis of naringenin-7-β-O-glycoside (3) and quercetin-7-β-O-glycoside (4). These compounds were obtained from naringenin (1) and quercetin (2) glycosylation catalyzed by Beauveria bassiana ATCC 7159. Screening of the best strain as a catalyst for glycosylation was carried out and the reaction conditions established. Cultures were grown in PDSM medium for 7 days at 27°C. After purification by reverse-phase preparative HPLC, naringenin-7-β-O-glycoside (3) and quercetin-7-β-O-glycoside (4) were identified by 1H and 13C NMR. The right position and β-configuration of the glucose was determined through HSQC and HMBC experiments. The vasorelaxation potential of naringenin, quercetin and its glycosylated derivatives was evaluated using isolated aorta in vitro models. Interestingly, results suggest that vasorelaxation properties of naringenin, rutin and its glycosides are due to different pathways. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0014-2999 1879-0712
DOI:	10.1016/j.ejphar.2014.03.014