Search Results - "Penny, Tayla"

Role of neuroserpin and N-Cadherin in mesenchymal stromal cell modulation of preterm brain injury by Penny, Tayla R., Malhotra, Atul

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Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males by Penny, Tayla R., Pham, Yen, Sutherland, Amy E., Lee, Joohyung, Jenkin, Graham, Fahey, Michael C., Miller, Suzanne L., McDonald, Courtney A.

“…Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to…”
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Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury: A Systematic Review & Meta-Analysis of Preclinical Studies by Nguyen, Timothy, Purcell, Elisha, Smith, Madeleine J, Penny, Tayla R, Paton, Madison C B, Zhou, Lindsay, Jenkin, Graham, Miller, Suzanne L, McDonald, Courtney A, Malhotra, Atul

“…Perinatal brain injury is a major contributor to long-term adverse neurodevelopment. There is mounting preclinical evidence for use of umbilical cord blood…”
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Multiple doses of umbilical cord blood cells improve long-term brain injury in the neonatal rat by Penny, Tayla R., Pham, Yen, Sutherland, Amy E., Mihelakis, Jamie G., Lee, Joohyung, Jenkin, Graham, Fahey, Michael C., Miller, Suzanne L., McDonald, Courtney A.

“…•Repeated doses of UCB improved neuropathology to a greater extent than a single dose.•Repeated doses of UCB reduced long-term functional deficits to a greater…”
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Intranasal Delivery of Mesenchymal Stromal Cells Protects against Neonatal Hypoxic⁻Ischemic Brain Injury by McDonald, Courtney A, Djuliannisaa, Zlatikha, Petraki, Maria, Paton, Madison C B, Penny, Tayla R, Sutherland, Amy E, Castillo-Melendez, Margie, Novak, Iona, Jenkin, Graham, Fahey, Michael C, Miller, Suzanne L

“…Cerebral palsy (CP) is a permanent motor disorder that results from brain injury and neuroinflammation during the perinatal period. Mesenchymal stromal cells…”
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Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury by McDonald, Courtney A, Penny, Tayla R, Paton, Madison C B, Sutherland, Amy E, Nekkanti, Lakshmi, Yawno, Tamara, Castillo-Melendez, Margie, Fahey, Michael C, Jones, Nicole M, Jenkin, Graham, Miller, Suzanne L

“…It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent…”
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Umbilical cord blood derived cell expansion: a potential neuroprotective therapy by Penny, Tayla R, Jenkin, Graham, Miller, Suzanne L, McDonald, Courtney A

“…Umbilical cord blood (UCB) is a rich source of beneficial stem and progenitor cells with known angiogenic, neuroregenerative and immune-modulatory properties…”
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Optimization of behavioral testing in a long-term rat model of hypoxic ischemic brain injury by Penny, Tayla R., Pham, Yen, Sutherland, Amy E., Smith, Madeleine J., Lee, Joohyung, Jenkin, Graham, Fahey, Michael C., Miller, Suzanne L., McDonald, Courtney A.

“…•In this study we determined the optimal behavioral tests for long-term functional assessment in a rodent model of neonatal brain injury•We demonstrate that…”
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Early administration of umbilical cord blood cells following brief high tidal volume ventilation in preterm sheep: a cautionary tale by Tran, Nhi T, Penny, Tayla R, Chan, Kyra Yy, Tang, Tanya, Papagianis, Paris C, Sepehrizadeh, Tara, Nekkanti, Lakshmi, Zahra, Valerie A, Pham, Yen, Yawno, Tamara, Nitsos, Ilias, Kelly, Sharmony B, Thiel, Alison M, de Veer, Michael, Alahmari, Dhafer M, Fahey, Michael C, Jenkin, Graham, Miller, Suzanne L, Galinsky, Robert, Polglase, Graeme R, McDonald, Courtney A

“…Umbilical cord blood (UCB) cells are a promising treatment for preterm brain injury. Access to allogeneic sources of UCB cells offer the potential for early…”
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Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury by Penny, Tayla R, Sutherland, Amy E, Mihelakis, Jamie G, Paton, Madison C B, Pham, Yen, Lee, Joohyung, Jones, Nicole M, Jenkin, Graham, Fahey, Michael C, Miller, Suzanne L, McDonald, Courtney A

“…Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current…”
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The Temporal Relationship between Blood-Brain Barrier Integrity and Microglial Response following Neonatal Hypoxia Ischemia by Jithoo, Arya, Penny, Tayla R, Pham, Yen, Sutherland, Amy E, Smith, Madeleine J, Petraki, Maria, Fahey, Michael C, Jenkin, Graham, Malhotra, Atul, Miller, Suzanne L, McDonald, Courtney A

“…Blood-brain barrier (BBB) dysfunction and neuroinflammation are key mechanisms of brain injury. We performed a time-course study following neonatal…”
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Multiple Doses of Umbilical Cord Blood Cells Improve Long‐Term Perinatal Brain Injury by Penny, Tayla, Pham, Yen, Sutherland, Amy, Mihelakis, Jamie, Lee, Joohyung, Jenkin, Graham, Fahey, Michael, Miller, Suzanne, McDonald, Courtney

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Neuroprotective Action of Tacrolimus before and after Onset of Neonatal Hypoxic-Ischaemic Brain Injury in Rats by Smith, Madeleine J, Penny, Tayla, Pham, Yen, Sutherland, Amy E, Jenkin, Graham, Fahey, Michael C, Paton, Madison C B, Finch-Edmondson, Megan, Miller, Suzanne L, McDonald, Courtney A

“…(1) Background: Neonatal brain injury can lead to permanent neurodevelopmental impairments. Notably, suppressing inflammatory pathways may reduce damage. To…”
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Feasibility of cord blood collection for autologous cell therapy applications in extremely preterm infants by Zhou, Lindsay, McDonald, Courtney A., Yawno, Tamara, Penny, Tayla, Miller, Suzanne L., Jenkin, Graham, Malhotra, Atul

“…Umbilical cord blood (UCB)-derived cells show strong promise as a treatment for neonatal brain injury in pre-clinical models and early-phase clinical trials…”
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Abstract 32 Expanded Umbilical Cord Blood CD34+ Cells Are Immunomodulatory in a Rat Model of Neonatal Brain Injury by Penny, Tayla, Watt, Ashalyn, Marzan, Ricki, Pham, Yen, Sutherland, Amy, Smith, Madeleine, Jenkin, Graham, Miller, Suzanne, McDonald, Courtney

“…Abstract Introduction Hypoxic ischemic (HI) insults during pregnancy and birth can result in neurodevelopmental disorders, including cerebral palsy. We have…”
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Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022) by Malhotra, Atul, Thebaud, Bernard, Paton, Madison C. B., Fleiss, Bobbi, Papagianis, Paris, Baker, Elizabeth, Bennet, Laura, Yawno, Tamara, Elwood, Ngaire, Campbell, Belinda, Chand, Kirat, Zhou, Lindsay, Penny, Tayla, Nguyen, Timothy, Pepe, Salvatore, Gunn, Alistair J., McDonald, Courtney A.

“…Despite considerable advances, there is a need to improve the outcomes of newborn infants, especially related to prematurity, encephalopathy and other…”
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Factors Influencing the Efficacy of Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury by Purcell, Elisha, Nguyen, Timothy, Smith, Madeleine, Penny, Tayla, Paton, Madison C B, Zhou, Lindsay, Jenkin, Graham, Miller, Suzanne L, McDonald, Courtney A, Malhotra, Atul

“…Abstract Introduction We have previously described preclinical literature which supports umbilical cord blood-derived cell (UCBC) therapy as an efficacious…”
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