Search Results - "Penno, A."

Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4 by Penno, Carlos A., Jäger, Petra, Laguerre, Claire, Hasler, Franziska, Hofmann, Andreas, Gass, Stephanie K., Wettstein-Ling, Barbara, Schaefer, Dirk J., Avrameas, Alexandre, Raulf, Friedrich, Wieczorek, Grazyna, Lehmann, Joachim C.U., Loesche, Christian, Roth, Lukas, Röhn, Till A.

“…Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory dermatosis characterized by abscesses, deep-seated nodules, sinus tracts, and fibrosis in…”
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Dietary patterns during pregnancy and maternal and birth outcomes in women with type 1 diabetes: the Environmental Determinants of Islet Autoimmunity (ENDIA) study by Thomson, Rebecca L., Brown, James D., Oakey, Helena, Palmer, Kirsten, Ashwood, Pat, Penno, Megan A. S., McGorm, Kelly J., Battersby, Rachel, Colman, Peter G., Craig, Maria E., Davis, Elizabeth A., Huynh, Tony, Harrison, Leonard C., Haynes, Aveni, Sinnott, Richard O., Vuillermin, Peter J., Wentworth, John M., Soldatos, Georgia, Couper, Jennifer J.

“…Aims/hypothesis Dietary patterns characterised by high intakes of vegetables may lower the risk of pre-eclampsia and premature birth in the general population…”
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Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters by Gai, Zhibo, Chu, Lei, Hiller, Christian, Arsenijevic, Denis, Penno, Carlos A, Montani, Jean-Pierre, Odermatt, Alex, Kullak-Ublick, Gerd A

“…Although the kidney is believed to play a minor role in bile acid (BA) excretion, chronic renal failure (CRF) has been reported to be associated with increased…”
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Optimization of Blood Handling and Peripheral Blood Mononuclear Cell Cryopreservation of Low Cell Number Samples by Hope, Christopher M., Huynh, Dao, Wong, Ying Ying, Oakey, Helena, Perkins, Griffith Boord, Nguyen, Trung, Binkowski, Sabrina, Bui, Minh, Choo, Ace Y. L., Gibson, Emily, Huang, Dexing, Kim, Ki Wook, Ngui, Katrina, Rawlinson, William D., Sadlon, Timothy, Couper, Jennifer J., Penno, Megan A. S., Barry, Simon C.

“…Background: Rural/remote blood collection can cause delays in processing, reducing PBMC number, viability, cell composition and function. To mitigate these…”
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Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1 by Odermatt, Alex, Da Cunha, Thierry, Penno, Carlos A, Chandsawangbhuwana, Charlie, Reichert, Christian, Wolf, Armin, Dong, Min, Baker, Michael E

“…The oxidized bile acid 7-oxoLCA (7-oxolithocholic acid), formed primarily by gut micro-organisms, is reduced in human liver to CDCA (chenodeoxycholic acid)…”
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Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid[S] by Penno, Carlos A., Morgan, Stuart A., Vuorinen, Anna, Schuster, Daniela, Lavery, Gareth G., Odermatt, Alex

“…11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mediates glucocorticoid activation and is currently considered as therapeutic target to treat metabolic…”
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Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer by Humphries, Julia M., Penno, Megan A.S., Weiland, Florian, Klingler-Hoffmann, Manuela, Zuber, Agnieszka, Boussioutas, Alex, Ernst, Matthias, Hoffmann, Peter

“…The timely detection of gastric cancer will contribute significantly towards effective treatment and is aided by the availability and reliability of…”
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Evaluation of protocol amendments to the Environmental Determinants of Islet Autoimmunity (ENDIA) study during the COVID‐19 pandemic by Penno, Megan A. S., Anderson, Amanda J., Thomson, Rebecca L., McGorm, Kelly, Barry, Simon C., Colman, Peter G., Craig, Maria E., Davis, Elizabeth A., Harris, Mark, Haynes, Aveni, Morahan, Grant, Oakey, Helena, Rawlinson, William D., Sinnott, Richard O., Soldatos, Georgia, Vuillermin, Peter J., Wentworth, John M., Harrison, Leonard C., Couper, Jennifer J.

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Potential mechanisms of the acute coronary syndrome presentation in patients with the coronary slow flow phenomenon — Insight from a plasma proteomic approach by Kopetz, Victoria A, Penno, Megan A.S, Hoffmann, Peter, Wilson, David P, Beltrame, John F

“…Abstract Aims The coronary slow flow phenomenon [CSFP] is a coronary microvascular disorder, characterized by delayed distal vessel opacification despite the…”
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Experiences of Caregivers and At-Risk Children Enrolled in a Prospective Pregnancy-Birth Cohort Study into the Causes of Type 1 Diabetes: The ENDIA Study by McGorm, Kelly J, Brown, James D, Roberts, Alison G, Greenbank, Susan, Brasacchio, Daniella, Sawyer, Alyssa C P, Oakey, Helena, Colman, Peter G, Craig, Maria E, Davis, Elizabeth A, Soldatos, Georgia, Thomson, Rebecca L, Wentworth, John M, Couper, Jennifer J, Penno, Megan A S, On Behalf Of The Endia Study Group

“…We sought research experiences of caregivers and their children were enrolled in the Environmental Determinants of Islet Autoimmunity (ENDIA) study. ENDIA is a…”
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2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer by Penno, Megan A.S., Klingler-Hoffmann, Manuela, Brazzatti, Julie A., Boussioutas, Alex, Putoczki, Tracy, Ernst, Matthias, Hoffmann, Peter

“…The gp130F/F genetically engineered mouse (GEM) model reproducibly and predictably develops a gastric adenoma phenotype resembling the primary lesions of human…”
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Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information by Thomson, Rebecca L, Oakey, Helena, Haynes, Aveni, Craig, Maria E, Harrison, Leonard C, Wentworth, John M, Anderson, Amanda, Ashwood, Pat, Barry, Simon, Brittain, Bek, Brown, James D, Colman, Peter G, Davis, Elizabeth A, Hamilton-Williams, Emma, Huynh, Dao, Huynh, Tony, Kim, Ki-Wook, McGorm, Kelly J, Morahan, Grant, Rawlinson, William, Sinnott, Richard O, Soldatos, Georgia, Tye-Din, Jason A, Vuillermin, Peter J, Penno, Megan A S, Couper, Jennifer J

“…IntroductionThe Environmental Determinants of Islet Autoimmunity (ENDIA) Study is an ongoing Australian prospective cohort study investigating how modifiable…”
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Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes by Penno, Megan A S, Couper, Jennifer J, Craig, Maria E, Colman, Peter G, Rawlinson, William D, Cotterill, Andrew M, Jones, Timothy W, Harrison, Leonard C

“…The incidence of type 1 diabetes has increased worldwide, particularly in younger children and those with lower genetic susceptibility. These observations…”
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Early-life factors contributing to type 1 diabetes by Craig, Maria E., Kim, Ki Wook, Isaacs, Sonia R., Penno, Megan A., Hamilton-Williams, Emma E., Couper, Jennifer J., Rawlinson, William D.

“…The incidence of type 1 diabetes has increased since the mid-twentieth century at a rate that is too rapid to be attributed to genetic predisposition alone…”
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Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor by Thoma, Gebhard, Miltz, Wolfgang, Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Klein, Kai, Evans, Amanda, Beerli, Christian, Röhn, Till A.

“…Leukotriene A4 hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B4 (LTB4). Preclinical studies have…”
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Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: A prospective cohort study by Harbison, Jessica E., Roth‐Schulze, Alexandra J., Giles, Lynne C., Tran, Cuong D., Ngui, Katrina M., Penno, Megan A., Thomson, Rebecca L., Wentworth, John M., Colman, Peter G., Craig, Maria E., Morahan, Grant, Papenfuss, Anthony T., Barry, Simon C., Harrison, Leonard C., Couper, Jennifer J.

“…Aims/hypothesis To investigate the longitudinal relationship between the gut microbiome, circulating short chain fatty acids (SCFAs) and intestinal…”
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Exploring Hearing Care Technology from Clinic to Capability by Penno, Kathryn A, Zakis, Justin A

“…Healthcare systems are traditionally a clinician-led and reactive structure that does not promote clients managing their health issues or concerns from an…”
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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase by Thoma, Gebhard, Markert, Christian, Lueoend, Rainer, Miltz, Wolfgang, Spanka, Carsten, Bollbuck, Birgit, Wolf, Romain M., Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Bednarczyk, Dallas, Wieczorek, Grazyna, Evans, Amanda, Beerli, Christian, Röhn, Till A.

“…The discovery of chiral amino alcohols derived from our previously disclosed clinical LTA4H inhibitor LYS006 is described. In a biochemical assay, their…”
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Identifying Candidate Serum Biomarkers of Exposure to Tunicamycins in Rats Using Two-Dimensional Electrophoresis by Penno, Megan A. S, Bacic, Antony, Colegate, Steven M, Hoffmann, Peter, Michalski, Wojtek P

“…A model for chronic corynetoxins poisoning has been established in rats exposed to the toxicologically bioequivalent inhibitor of N-linked glycosylation the…”
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Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness" by Penno, Carlos A, Wack, Nathalie, Laguerre, Claire, Hasler, Franziska, Numao, Shin, Röhn, Till A

“…Increased airway hyperresponsiveness and epithelial remodeling in asthmatic LTA H-KO mice may be mediated by CysLTs rather than elevated tripeptide PGP…”
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