Search Results - "Pennisi, Ivana"
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Rapid Detection of Mobilized Colistin Resistance using a Nucleic Acid Based Lab-on-a-Chip Diagnostic System
Published in Scientific reports (21-05-2020)“…The increasing prevalence of antimicrobial resistance is a serious threat to global public health. One of the most concerning trends is the rapid spread of…”
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Handheld Point-of-Care System for Rapid Detection of SARS-CoV‑2 Extracted RNA in under 20 min
Published in ACS central science (24-02-2021)“…The COVID-19 pandemic is a global health emergency characterized by the high rate of transmission and ongoing increase of cases globally. Rapid point-of-care…”
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Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-care
Published in Scientific reports (24-05-2022)“…Cervical cancer affects over half a million people worldwide each year, the majority of whom are in resource-limited settings where cytology screening is not…”
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Loop-Mediated Isothermal Amplification Assay for Detecting Tumor Markers and Human Papillomavirus: Accuracy and Supplemental Diagnostic Value to Endovaginal MRI in Cervical Cancer
Published in Frontiers in oncology (01-11-2021)“…To establish the sensitivity and specificity of a human papillomavirus (HPV) and tumor marker DNA/mRNA assay for detecting cervical cancer that is…”
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Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care
Published in Microbiology spectrum (15-06-2023)“…Human malaria is a life-threatening parasitic disease with high impact in the sub-Saharan Africa region, where 95% of global cases occurred in 2021. While most…”
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Coupling Machine Learning and High Throughput Multiplex Digital PCR Enables Accurate Detection of Carbapenem-Resistant Genes in Clinical Isolates
Published in Frontiers in molecular biosciences (23-11-2021)“…Rapid and accurate identification of patients colonised with carbapenemase-producing organisms (CPOs) is essential to adopt prompt prevention measures to…”
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Transition metal homoeostasis is key to metabolism and drug tolerance of Mycobacterium abscessus
Published in NPJ ANTIMICROBIALS AND RESISTANCE (01-01-2024)“…Antimicrobial resistance (AMR) is one of the major challenges humans are facing this century. Understanding the mechanisms behind the rise of AMR is therefore…”
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Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study
Published in The Lancet. Microbe (01-11-2021)“…Emergency admissions for infection often lack initial diagnostic certainty. COVID-19 has highlighted a need for novel diagnostic approaches to indicate…”
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Amplification Curve Analysis: Data-Driven Multiplexing Using Real-Time Digital PCR
Published in Analytical chemistry (Washington) (06-10-2020)“…Information about the kinetics of PCR reactions is encoded in the amplification curve. However, in digital PCR (dPCR), this information is typically neglected…”
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Discrimination of bacterial and viral infection using host-RNA signatures integrated in a lab-on-chip platform
Published in Biosensors & bioelectronics (15-11-2022)“…The unmet clinical need for accurate point-of-care (POC) diagnostic tests able to discriminate bacterial from viral infection demands a solution that can be…”
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Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test
Published in Journal of antimicrobial chemotherapy (01-12-2018)“…Polymyxins are currently considered a last-resort treatment for infections caused by MDR Gram-negative bacteria. Recently, the emergence of…”
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Rapid, Portable, and Electricity-free Sample Extraction Method for Enhanced Molecular Diagnostics in Resource-Limited Settings
Published in Analytical chemistry (Washington) (16-07-2024)“…The COVID-19 pandemic has highlighted the need for rapid and reliable diagnostics that are accessible in resource-limited settings. To address this pressing…”
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Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells
Published in Chemical research in toxicology (20-08-2018)“…Antimicrobial resistance is a major threat the world is currently facing. Development of new antibiotics and the assessment of their toxicity represent…”
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Rapid detection of Klebsiella pneumoniae using an auto-calibrated ISFET-array Lab-on-Chip platform
Published in 2019 IEEE Biomedical Circuits and Systems Conference (BioCAS) (01-10-2019)“…This paper presents the rapid detection of Klebsiella pneumonia, a major worldwide source and shuttle for antibiotic resistance, by a CMOS-based Lab-on-chip…”
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