Search Results - "Pennington, Zachary T"

Basolateral Amygdala to Orbitofrontal Cortex Projections Enable Cue-Triggered Reward Expectations by Lichtenberg, Nina T, Pennington, Zachary T, Holley, Sandra M, Greenfield, Venuz Y, Cepeda, Carlos, Levine, Michael S, Wassum, Kate M

“…To make an appropriate decision, one must anticipate potential future rewarding events, even when they are not readily observable. These expectations are…”
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Breakdown of spatial coding and interneuron synchronization in epileptic mice by Shuman, Tristan, Aharoni, Daniel, Cai, Denise J., Lee, Christopher R., Chavlis, Spyridon, Page-Harley, Lucia, Vetere, Lauren M., Feng, Yu, Yang, Chen Yi, Mollinedo-Gajate, Irene, Chen, Lingxuan, Pennington, Zachary T., Taxidis, Jiannis, Flores, Sergio E., Cheng, Kevin, Javaherian, Milad, Kaba, Christina C., Rao, Naina, La-Vu, Mimi, Pandi, Ioanna, Shtrahman, Matthew, Bakhurin, Konstantin I., Masmanidis, Sotiris C., Khakh, Baljit S., Poirazi, Panayiota, Silva, Alcino J., Golshani, Peyman

“…Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain unknown. Interneuron death and reorganization during epileptogenesis…”
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A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear by Rajbhandari, Abha K, Octeau, Christopher J, Gonzalez, Sarah, Pennington, Zachary T, Mohamed, Farzanna, Trott, Jeremy, Chavez, Jasmine, Ngyuen, Erin, Keces, Natasha, Hong, Weizhe Z, Neve, Rachael L, Waschek, James, Khakh, Baljit S, Fanselow, Michael S

“…Trauma can cause dysfunctional fear regulation leading some people to develop disorders, such as post-traumatic stress disorder (PTSD). The amygdala regulates…”
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Minian, an open-source miniscope analysis pipeline by Dong, Zhe, Mau, William, Feng, Yu, Pennington, Zachary T, Chen, Lingxuan, Zaki, Yosif, Rajan, Kanaka, Shuman, Tristan, Aharoni, Daniel, Cai, Denise J

“…Miniature microscopes have gained considerable traction for in vivo calcium imaging in freely behaving animals. However, extracting calcium signals from raw…”
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Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior by Pennington, Zachary T., LaBanca, Alexa R., Sompolpong, Patlapa, Abdel-Raheim, Shereen D., Ko, Bumjin, Christenson Wick, Zoe, Feng, Yu, Dong, Zhe, Francisco, Taylor R., Bacon, Madeline E., Chen, Lingxuan, Fulton, Sasha L., Maze, Ian, Shuman, Tristan, Cai, Denise J.

“…Stress can have profound consequences on mental health. While much is known about the neural circuits supporting associative memories of stressful events, our…”
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Reward, interrupted: Inhibitory control and its relevance to addictions by Jentsch, James David, Pennington, Zachary T.

“…There are broad individual differences in the ability to voluntarily and effortfully suppress motivated, reward-seeking behaviors, and this review presents the…”
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A return to the psychiatric dark ages with a two-system framework for fear by Fanselow, Michael S., Pennington, Zachary T.

“…The past several decades has seen considerable progress in our understanding of the neurobiology of fear and anxiety. These advancements were spurred on by…”
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ezTrack: An open-source video analysis pipeline for the investigation of animal behavior by Pennington, Zachary T., Dong, Zhe, Feng, Yu, Vetere, Lauren M., Page-Harley, Lucia, Shuman, Tristan, Cai, Denise J.

“…Tracking animal behavior by video is one of the most common tasks in the life sciences. Although commercial software exists for executing this task, they often…”
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The Danger of LeDoux and Pine’s Two-System Framework for Fear by Fanselow, Michael S, Pennington, Zachary T

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Dissecting impulsivity and its relationships to drug addictions by Jentsch, J. David, Ashenhurst, James R., Cervantes, M. Catalina, Groman, Stephanie M., James, Alexander S., Pennington, Zachary T.

“…Addictions are often characterized as forms of impulsive behavior. That said, it is often noted that impulsivity is a multidimensional construct, spanning…”
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Propranolol Inhibits Reactivation of Fear Memory by Pennington, Zachary T., Cai, Denise J.

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The Medial Orbitofrontal Cortex-Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice by Lichtenberg, Nina T, Sepe-Forrest, Linnea, Pennington, Zachary T, Lamparelli, Alexander C, Greenfield, Venuz Y, Wassum, Kate M

“…Adaptive reward-related decision making requires accurate prospective consideration of the specific outcome of each option and its current desirability. Often…”
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Indirect Targeting of Subsuperficial Brain Structures With Transcranial Magnetic Stimulation Reveals a Promising Way Forward in the Treatment of Fear by Pennington, Zachary T., Fanselow, Michael S.

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Offline ensemble co-reactivation links memories across days by Zaki, Yosif, Pennington, Zachary T., Morales-Rodriguez, Denisse, Bacon, Madeline E., Ko, BumJin, Francisco, Taylor R., LaBanca, Alexa R., Sompolpong, Patlapa, Dong, Zhe, Lamsifer, Sophia, Chen, Hung-Tu, Carrillo Segura, Simón, Christenson Wick, Zoé, Silva, Alcino J., Rajan, Kanaka, van der Meer, Matthijs, Fenton, André, Shuman, Tristan, Cai, Denise J.

“…Abstract Memories are encoded in neural ensembles during learning 1–6 and are stabilized by post-learning reactivation 7–17 . Integrating recent experiences…”
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The Ventromedial Prefrontal Cortex in a Model of Traumatic Stress: Fear Inhibition or Contextual Processing? by Pennington, Zachary T, Anderson, Austin S, Fanselow, Michael S

“…The ventromedial prefrontal cortex (vmPFC) has consistently appeared altered in post-traumatic stress disorder (PTSD). Although the vmPFC is thought to support…”
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Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma by Pennington, Zachary T, Trott, Jeremy M, Rajbhandari, Abha K, Li, Kevin, Walwyn, Wendy M, Evans, Christopher J, Fanselow, Michael S

“…Despite the large comorbidity between PTSD and opioid use disorders, as well as the common treatment of physical injuries resulting from trauma with opioids,…”
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Across Sex and Age: Learning and Memory and Patterns of Avian Hippocampal Gene Expression by Kosarussavadi, Saritha, Pennington, Zachary T, Covell, Jeremy, Blaisdell, Aaron P, Schlinger, Barney A

“…Age-related decrements in cognitive ability have been proposed to stem from deteriorating function of the hippocampus. Many birds are long lived, especially…”
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Compromised NMDA/Glutamate Receptor Expression in Dopaminergic Neurons Impairs Instrumental Learning, But Not Pavlovian Goal Tracking or Sign Tracking by James, Alex S, Pennington, Zachary T, Tran, Phu, Jentsch, James David

“…Two theories regarding the role for dopamine neurons in learning include the concepts that their activity serves as a (1) mechanism that confers incentive…”
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Compromised NMDA/Glutamate Receptor Expression in Dopaminergic Neurons Impairs Instrumental Learning, But Not Pavlovian Goal Tracking or Sign Tracking1,2,3 by James, Alex S., Pennington, Zachary T., Tran, Phu, Jentsch, James David

“…Behavior is shaped to a dramatic degree by the occurrence of rewards, through both pavlovian and instrumental conditioning processes; these mechanisms give…”
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