Angiogenesis As A Predictor Of Survival After Surgical Resection For Stage I Non-Small-Cell Lung Cancer

Angiogenesis As A Predictor Of Survival After Surgical Resection For Stage I Non-Small-Cell Lung Cancer

Objectives: Some patients with surgically resected stage I non-small-cell lung cancer eventually have metastatic disease. A histologic marker of metastatic potential and diminished survival for stage I non-small-cell lung cancer may distinguish this patient population. This study evaluates the degre...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of thoracic and cardiovascular surgery Vol. 115; no. 3; pp. 652 - 659
Main Authors: Duarte, Ignacio G., Bufkin, Bradley L., Pennington, Marian F., Gal, Anthony A., Cohen, Cynthia, Kosinski, Andrzej S., Mansour, Kamal A., Miller, Joseph I.
Format: Journal Article
Language:English
Published: United States Mosby, Inc 01-03-1998
AATS/WTSA
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Antibodies, Monoclonal
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Factor VIII - immunology
Female
Humans
Immunohistochemistry
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Middle Aged
Neovascularization, Pathologic
Platelet Endothelial Cell Adhesion Molecule-1 - immunology
Prognosis
Retrospective Studies
Survival Analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: Some patients with surgically resected stage I non-small-cell lung cancer eventually have metastatic disease. A histologic marker of metastatic potential and diminished survival for stage I non-small-cell lung cancer may distinguish this patient population. This study evaluates the degree of angiogenesis as a predictor of cancer-related death after operation for stage I non-small-cell lung cancer. Methods: Demographic, surgical, and histopathologic data, including presence of vascular invasion, were reviewed for 106 patients with stage I non-small-cell lung cancer from 1985 through 1990. Visual quantitation of microvessels immunostained with factor VIII–related antigen and CD31 in 5 μm sections from the paraffin blocks of tissue defined rumor angiogenesis. Results: Follow-up was 95.1% complete, mean 5.2 ± 3.0 years. Lung cancer-related mortality rate was 24.4% at 5 years. Mean microvessel counts were 20.7 ± 11.2 for FVIII and 29.6  ± 18.1 for CD31. Univariate analysis revealed an FVIII count of at least 20 ( p = 0.025) and blood vessel invasion ( p = 0.017) to be significant predictors of disease-related death. After adjustment for other patient and tumor characteristics, multivariate Cox regression analysis found an FVIII count of at least 20 (hazard ratio 2.9) and blood vessel invasion (hazard ratio 3.7) to be significant independent correlates of lung cancer death ( p = 0.018 and p = 0.011, respectively). CD31 quantitation did not predict survival on univariate or multivariate analyses and did not correlate strongly with FVIII quantitation (Spearman's rank correlation r = 0.19). Conclusions: This analysis reveals a significant association between tumor neovascularization and cancer-related mortality rate among patients with stage I non-small-cell lung cancer. Microvessel quantitation of FVIII, as an indicator of tumor angiogenesis and metastatic potential, may define a subset of patients with stage I non-small-cell lung cancer who could benefit from adjuvant therapy after surgical resection. (J Thorac Cardiovasc Surg 1998;115:652-9)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-5223
1097-685X
DOI:10.1016/S0022-5223(98)70331-9