Search Results - "Pennington, Kathleen A."

A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice by Mishra, Akansha, Ruano, Simone Hernandez, Saha, Pradip K, Pennington, Kathleen A

“…Gestational diabetes mellitus (GDM) affects 7-18% of all pregnancies. Despite its high prevalence, there is no widely accepted animal model. To address this,…”
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The uterine secretome initiates growth of gynecologic tissues in ectopic locations by Sunde, Jan, Wasickanin, Morgan, Katz, Tiffany A, Gillette, Laurel, Bidadi, Sanam, O'Neil, Derek, Masand, Ramya, Burney, Richard O, Pennington, Kathleen A

“…Endosalpingiosis (ES) and endometriosis (EM) refer to the growth of tubal and endometrial epithelium respectively, outside of their site of origin. We…”
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Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion by Dong, Yuanlin, Ruano, Simone Hernandez, Mishra, Akansha, Pennington, Kathleen A, Yallampalli, Chandrasekhar

“…Gestational diabetes mellitus (GDM) is associated with defective pancreatic β-cell adaptation in pregnancy, but the underlying mechanism remains obscure. Our…”
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Preeclampsia: multiple approaches for a multifactorial disease by Pennington, Kathleen A, Schlitt, Jessica M, Jackson, Daniel L, Schulz, Laura C, Schust, Danny J

“…Preeclampsia is a pregnancy-specific disorder characterized by hypertension and excess protein excretion in the urine. It is an important cause of maternal and…”
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Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota by Mercado-Evans, Vicki, Mejia, Marlyd E., Zulk, Jacob J., Ottinger, Samantha, Hameed, Zainab A., Serchejian, Camille, Marunde, Madelynn G., Robertson, Clare M., Ballard, Mallory B., Ruano, Simone H., Korotkova, Natalia, Flores, Anthony R., Pennington, Kathleen A., Patras, Kathryn A.

“…Group B Streptococcus (GBS) is a pervasive perinatal pathogen, yet factors driving GBS dissemination in utero are poorly defined. Gestational diabetes mellitus…”
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Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice by Yallampalli, Chandra, Betancourt, Ancizar, Mishra, Akansha, Pennington, Kathleen A, Ruano, Simone Hernandez, Tacam, Moises, Chauhan, Madhu

“…Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of…”
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Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta by Starks, Rebekah R, Abu Alhasan, Rabab, Kaur, Haninder, Pennington, Kathleen A, Schulz, Laura C, Tuteja, Geetu

“…During pregnancy, the placenta is important for transporting nutrients and waste between the maternal and fetal blood supply, secreting hormones, and serving…”
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Maternal Hyperleptinemia Is Associated with Male Offspring's Altered Vascular Function and Structure in Mice by Pennington, Kathleen A, Ramirez-Perez, Francisco I, Pollock, Kelly E, Talton, Omonseigho O, Foote, Christopher A, Reyes-Aldasoro, Constantino C, Wu, Ho-Hsiang, Ji, Tieming, Martinez-Lemus, Luis A, Schulz, Laura C

“…Children of mothers with gestational diabetes have greater risk of developing hypertension but little is known about the mechanisms by which this occurs. The…”
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Consequences of conceptus exposure to colony-stimulating factor 2 on survival, elongation, interferon-τ secretion, and gene expression by Loureiro, Barbara, Block, Jeremy, Favoreto, Mauricio G, Carambula, Silvia, Pennington, Kathleen A, Ealy, Alan D, Hansen, Peter J

“…Exposure of bovine conceptuses to colony-stimulating factor 2 (CSF2) from days 5 to 7 of development can increase the percentage of transferred conceptuses…”
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Several fibroblast growth factors are expressed during pre-attachment bovine conceptus development and regulate interferon-tau expression from trophectoderm by Cooke, Flavia N T, Pennington, Kathleen A, Yang, Qien, Ealy, Alan D

“…The trophectoderm-derived factor interferon tau (IFNT) maintains the uterus in a pregnancy-receptive state in cattle and sheep. Fibroblast growth factors…”
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The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm by Pennington, Kathleen A, Ealy, Alan D

“…Bone morphogenetic proteins (BMPs) were first described for their roles in bone formation, but they now also are known to possess additional activities,…”
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Conditional knockout of leptin receptor in the female reproductive tract reduces fertility due to parturition defects in mice by Pennington, Kathleen A., Oestreich, Arin K., Cataldo, Kylie H., Fogliatti, Candace M., Lightner, Celeste, Lydon, John P., Schulz, Laura C.

“…Leptin is required for fertility, including initiation of estrous cycles. It is therefore challenging to assess the role of leptin signaling during pregnancy…”
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Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet by Dong, Yuanlin, van der Walt, Nicola, Pennington, Kathleen A., Yallampalli, Chandra

“…Purpose Adrenomedullin (ADM) levels are elevated in gestational and type 2 diabetic patients. ADM also stimulates lipolysis in vitro. Disturbed lipid…”
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In Utero and Postnatal Exposure to High Fat, High Sucrose Diet Suppressed Testis Apoptosis and Reduced Sperm Count by Mao, Jiude, Pennington, Kathleen A., Talton, Omonseigho O., Schulz, Laura C., Sutovsky, Miriam, Lin, Yan, Sutovsky, Peter

“…Obesity affects male fertility and maternal diabetes affects the offspring sperm epigenome. However, the effects of in utero exposure to maternal glucose…”
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Effects of acute exposure to a high-fat, high-sucrose diet on gestational glucose tolerance and subsequent maternal health in mice by Pennington, Kathleen A, Walt, Nicola van der, Pollock, Kelly E, Talton, Omonseigho O, Schulz, Laura C

“…Gestational diabetesmellitus (GDM) is a common obstetric complication. Half of women who have GDM will go on to develop type 2 diabetes. Understanding the…”
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Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice by Pennington, Kathleen A., Dong, Yuanlin, Ruano, Simone Hernandez, van der Walt, Nicola, Sangi-Haghpeykar, Haleh, Yallampalli, Chandrasekhar

“…During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM)…”
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Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice by Rosenfeld, Cheryl S, Sieli, Paizlee T, Warzak, Denise A, Ellersieck, Mark R, Pennington, Kathleen A, Roberts, R Michael

“…Reports that maternal diet influences coat color in mouse offspring carrying the agouti A(vy) allele have received considerable attention because the range,…”
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Leptin and the Placental Response to Maternal Food Restriction During Early Pregnancy in Mice by SCHULZ, Laura Clamon, SCHLITT, Jessica M, CAESAR, Gerialisa, PENNINGTON, Kathleen A

“…Several studies have demonstrated that maternal undernutrition or overnutrition during pregnancy can have negative consequences for the health of children born…”
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Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice by Talton, Omonseigho O, Pennington, Kathleen A, Pollock, Kelly E, Bates, Keenan, Ma, Lixin, Ellersieck, Mark R, Schulz, Laura C

“…Maternal obesity and gestational diabetes are prevalent worldwide. Offspring of mothers with these conditions weigh more and are predisposed to metabolic…”
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Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice by Pollock, Kelly E, Stevens, Damaiyah, Pennington, Kathleen A, Thaisrivongs, Rose, Kaiser, Jennifer, Ellersieck, Mark R, Miller, Dennis K, Schulz, Laura Clamon

“…Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult…”
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