Search Results - "Pennington, K N"

Virologic and Immunologic Benefits of Initial Combination Therapy with Zidovudine and Zalcitabine or Didanosine Compared with Zidovudine Monotherapy by Schooley, Robert T., Ramirez-Ronda, Carlos, Lange, Joep M. A., Cooper, David A., Lavelle, James, Lefkowitz, Lewis, Moore, Mark, Larder, Brendan A., Clair, Marty St, Willem Mulder, Jan, McKinnis, Ray, Pennington, Kevin N., Harrigan, P. Richard, Kinghorn, Ian, Steel, Helen, Rooney, James F.

“…A randomized controlled study was done to determine whether initial combination therapy with zidovudine and zalcitabine or zidovudine and didanosine would…”
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Transcription of the RelB gene is regulated by NF-κB by BREN, Gary D, SOLAN, Nancie J, MIYOSHI, Hiroko, PENNINGTON, Kevin N, POBST, Lori J, PAYA, Carlos V

“…RelA and RelB are two members of the NF-κB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by…”
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Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes by Trushin, Sergey A., Pennington, Kevin N., Carmona, Eva M., Asin, Susana, Savoy, Doris N., Billadeau, Daniel D., Paya, Carlos V.

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Protein Kinase C and Calcineurin Synergize to Activate IκB Kinase and NF-κB in T Lymphocytes by Trushin, Sergey A., Pennington, Kevin N., Algeciras-Schimnich, Alicia, Paya, Carlos V.

“…The nuclear factor of κB (NF-κB) is a ubiquitous transcription factor that is key in the regulation of the immune response and inflammation. T cell receptor…”
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Effect of influenza immunization on immunologic and virologic characteristics of pediatric patients infected with human immunodeficiency virus by JACKSON, CYNTHIA R, VAVRO, CINDY L, VALENTINE, MEGAN E, PENNINGTON, KEVIN N, LANIER, E RANDALL, KATZ, SAMUEL L, DILIBERTI, JOHN H, MCKINNEY, ROSS E, WILFERT, CATHERINE M, CLAIR, MARTY H. ST

“…OBJECTIVES.We evaluated the responses of HIV-infected children to a single dose of split-virus influenza vaccine and the relationship to viral load and other…”
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Rapid screening of antiretroviral combinations by St Clair, M, Pennington, K N, Rooney, J, Barry, D W

“…Increasing evidence supports the view that therapy with combinations of antiretroviral drugs provides greater and more sustained benefits in the treatment of…”
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Signal-induced Ubiquitination of IκB Kinase-β by Carter, Robert S., Pennington, Kevin N., Ungurait, Bradley J., Arrate, Pia, Ballard, Dean W.

“…Initiation of the genetic programs for inflammation and immunity involves nuclear mobilization of transcription factor NF-κB. This signal-dependent process is…”
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In Vivo Identification of Inducible Phosphoacceptors in the IKKγ/NEMO Subunit of Human IκB Kinase by Carter, Robert S., Pennington, Kevin N., Ungurait, Bradley J., Ballard, Dean W.

“…Transcription factor NF-κB plays a pivotal regulatory role in the genetic programs for cell cycle progression and inflammation. Nuclear translocation of NF-κB…”
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Serine 32 and serine 36 of IκBα are directly phosphorylated by protein kinase CKII in Vitro by Taylor, Julie A, Bren, Gary D, Pennington, Kevin N, Trushin, Sergey A, Asin, Susana, Paya, Carlos V

“…IκBα is an inherently unstable protein which binds to and retains the ubiquitous transcription factor NFκB in the cytoplasm of resting cells. A continuous low…”
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In vitro comparison of selected triple-drug combinations for suppression of HIV-1 replication: the Inter-Company Collaboration Protocol by St Clair, M H, Pennington, K N, Rooney, J, Barry, D W

“…Ten different three-drug combinations have been analyzed for their ability to prevent HIV-induced cytopathic effects (CPEs) in a continuous human…”
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Human immunodeficiency virus type 1 drug susceptibility during zidovudine (AZT) monotherapy compared with AZT plus 2',3'-dideoxyinosine or AZT plus 2',3'-dideoxycytidine combination therapy by Larder, BA, Kohli, A, Bloor, S, Kemp, S D, Harrigan, PR, Schooley, R T, Lange, JMA, Pennington, K N, St Clair, MH

“…Human immunodeficiency virus type 1 (HIV-1) isolates obtained prior to and during a combination therapy trial comparing zidovudine (AZT; 3'-azidothymidine)…”
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Human immunodeficiency virus type 1 drug susceptibility during zidovudine (AZT) monotherapy compared with AZT plus 2',3'-dideoxyinosine or AZT plus 2',3'-dideoxycytidine combination therapy. The protocol 34,225-02 Collaborative Group by Larder, B A, Kohli, A, Bloor, S, Kemp, S D, Harrigan, P R, Schooley, R T, Lange, J M, Pennington, K N, St Clair, M H

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Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Influenza Virus Host Resistance in Mice by Burleson, Gary R., Lebrec, Hervé, Yang, Yung G., Ibanes, Joelle D., Pennington, Kevin N., Birnbaum, Linda S.

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes numerous immunotoxic effects including thymic involution and an immunosuppression of nonspecific as well as…”
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PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha by Bren, G D, Pennington, K N, Paya, C V

“…The atypical PKC isoenzymes, zeta and iota, activate NF-kappaB, a mechanism thought to mediate the anti-apoptotic and proliferative features of these kinases…”
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Positive Regulation of IκB Kinase Signaling by Protein Serine/Threonine Phosphatase 2A by Kray, Arlene E., Carter, Robert S., Pennington, Kevin N., Gomez, Rey J., Sanders, Laura E., Llanes, Joan M., Khan, Wasif N., Ballard, Dean W., Wadzinski, Brian E.

“…Transcription factor NF-κB plays a key regulatory role in the cellular response to pro-inflammatory cytokines such as tumor necrosis factor-α (TNF). In the…”
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I Kappa B Kinase-Dependent Chronic Activation of NF- Kappa B Is Necessary for p21 super(WAF1/Cip1) Inhibition of Differentiation-Induced Apoptosis of Monocytes by Pennington, K N, Taylor, JA, Bren, G D, Paya, C V

“…The molecular mechanisms regulating monocyte differentiation to macrophages remain unknown. Although the transcription factor NF- Kappa B participates in…”
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IkappaB kinase-dependent chronic activation of NF-kappaB is necessary for p21(WAF1/Cip1) inhibition of differentiation-induced apoptosis of monocytes by Pennington, K N, Taylor, J A, Bren, G D, Paya, C V

“…The molecular mechanisms regulating monocyte differentiation to macrophages remain unknown. Although the transcription factor NF-kappaB participates in…”
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Transcription of the RelB gene is regulated by NF-kappaB by Bren, G D, Solan, N J, Miyoshi, H, Pennington, K N, Pobst, L J, Paya, C V

“…RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by…”
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Human Immunodeficiency Virus Reactivation by Phorbol Esters or T-Cell Receptor Ligation Requires both PKCα and PKCθ by TRUSHIN, Sergey A, BREN, Gary D, ASIN, Susana, PENNINGTON, Kevin N, PAYA, Carlos V, BADLEY, Andrew D

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Site-specific Monoubiquitination of IκB Kinase IKKβ Regulates Its Phosphorylation and Persistent Activation by Carter, Robert S., Pennington, Kevin N., Arrate, Pia, Oltz, Eugene M., Ballard, Dean W.

“…Transcription factor NF-κB governs the expression of multiple genes involved in cell growth, immunity, and inflammation. Nuclear translocation of NF-κB is…”
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