Search Results - "Pennington, J."

Marine primary production in relation to climate variability and change by Chavez, Francisco P, Messié, Monique, Pennington, J Timothy

“…Marine photosynthetic plankton are responsible for approximately 50 petagrams (10(15)) of carbon per year of net primary production, an amount equivalent to…”
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Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells by Sumaria, Nital, Grandjean, Capucine L., Silva-Santos, Bruno, Pennington, Daniel J.

“…Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly…”
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Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress by Tao, Randa, Coleman, Mitchell C., Pennington, J. Daniel, Ozden, Ozkan, Park, Seong-Hoon, Jiang, Haiyan, Kim, Hyun-Seok, Flynn, Charles Robb, Hill, Salisha, Hayes McDonald, W., Olivier, Alicia K., Spitz, Douglas R., Gius, David

“…Genetic deletion of the mitochondrial deacetylase sirtuin-3 ( Sirt3) results in increased mitochondrial superoxide, a tumor-permissive environment, and mammary…”
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Murine CD27⁽⁻⁾ Vγ6⁽⁺⁾ γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages by Rei, Margarida, Gonçalves-Sousa, Natacha, Lança, Telma, Thompson, Richard G, Mensurado, Sofia, Balkwill, Frances R, Kulbe, Hagen, Pennington, Daniel J, Silva-Santos, Bruno

“…Cancer-associated inflammation mobilizes a variety of leukocyte populations that can inhibit or enhance tumor cell growth in situ. These subsets include γδ T…”
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Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study by Cabrera, Claudia P, Manson, Joanna, Shepherd, Joanna M, Torrance, Hew D, Watson, David, Longhi, M Paula, Hoti, Mimoza, Patel, Minal B, O'Dwyer, Michael, Nourshargh, Sussan, Pennington, Daniel J, Barnes, Michael R, Brohi, Karim

“…Severe trauma induces a widespread response of the immune system. This "genomic storm" can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome…”
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SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress by Kim, Hyun-Seok, Patel, Krish, Muldoon-Jacobs, Kristi, Bisht, Kheem S., Aykin-Burns, Nukhet, Pennington, J. Daniel, van der Meer, Riet, Nguyen, Phuongmai, Savage, Jason, Owens, Kjerstin M., Vassilopoulos, Athanassios, Ozden, Ozkan, Park, Seong-Hoon, Singh, Keshav K., Abdulkadir, Sarki A., Spitz, Douglas R., Deng, Chu-Xia, Gius, David

“…The sirtuin gene family ( SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3 −/− mouse…”
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Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific by Ryan, John P, Cline, Danelle E, Joseph, John E, Margolina, Tetyana, Santora, Jarrod A, Kudela, Raphael M, Chavez, Francisco P, Pennington, J Timothy, Wahl, Christopher, Michisaki, Reiko, Benoit-Bird, Kelly, Forney, Karin A, Stimpert, Alison K, DeVogelaere, Andrew, Black, Nancy, Fischer, Mark

“…This study examines the occurrence of humpback whale (Megaptera novaeangliae) song in the northeast Pacific from three years of continuous recordings off…”
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SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress by Vassilopoulos, Athanassios, Pennington, J Daniel, Andresson, Thorkell, Rees, David M, Bosley, Allen D, Fearnley, Ian M, Ham, Amy, Flynn, Charles Robb, Hill, Salisha, Rose, Kristie Lindsey, Kim, Hyun-Seok, Deng, Chu-Xia, Walker, John E, Gius, David

“…Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into…”
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Interleukin 7 (IL-7) selectively promotes mouse and human IL-17–producing γδ cells by Michel, Marie-Laure, Pang, Dick J, Haque, Syeda F. Y, Potocnik, Alexandre J, Pennington, Daniel J, Hayday, Adrian C

“…IL-17–producing CD27 ⁻ γδ cells (γδ ²⁷⁻ cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity…”
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Causality of an extreme harmful algal bloom in Monterey Bay, California, during the 2014–2016 northeast Pacific warm anomaly by Ryan, J. P., Kudela, R. M., Birch, J. M., Blum, M., Bowers, H. A., Chavez, F. P., Doucette, G. J., Hayashi, K., Marin, R., Mikulski, C. M., Pennington, J. T., Scholin, C. A., Smith, G. J., Woods, A., Zhang, Y.

“…An ecologically and economically disruptive harmful algal bloom (HAB) affected much of the northeast Pacific margin in 2015, during a prolonged oceanic warm…”
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Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures by Galson, Jacob D, Schaetzle, Sebastian, Bashford-Rogers, Rachael J M, Raybould, Matthew I J, Kovaltsuk, Aleksandr, Kilpatrick, Gavin J, Minter, Ralph, Finch, Donna K, Dias, Jorge, James, Louisa K, Thomas, Gavin, Lee, Wing-Yiu Jason, Betley, Jason, Cavlan, Olivia, Leech, Alex, Deane, Charlotte M, Seoane, Joan, Caldas, Carlos, Pennington, Daniel J, Pfeffer, Paul, Osbourn, Jane

“…Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to…”
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A modular system for Clostridium shuttle plasmids by Heap, John T., Pennington, Oliver J., Cartman, Stephen T., Minton, Nigel P.

“…Despite their medical and industrial importance, our basic understanding of the biology of the genus Clostridium is rudimentary in comparison to their aerobic…”
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Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin by Sancho, David, Mourão-Sá, Diego, Joffre, Olivier P, Schulz, Oliver, Rogers, Neil C, Pennington, Daniel J, Carlyle, James R, Reis e Sousa, Caetano

“…The mouse CD8alpha+ DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing specific antigen targeting to…”
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Abundance and Biogeography of Picoprasinophyte Ecotypes and Other Phytoplankton in the Eastern North Pacific Ocean by Simmons, Melinda P, Sudek, Sebastian, Monier, Adam, Limardo, Alexander J, Jimenez, Valeria, Perle, Christopher R, Elrod, Virginia A, Pennington, J Timothy, Worden, Alexandra Z

“…Eukaryotic algae within the picoplankton size class (≤2 μm in diameter) are important marine primary producers, but their spatial and ecological distributions…”
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iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility by Chao-Chu, Jennifer, Murtough, Stephen, Zaman, Najwa, Pennington, Daniel J., Blaydon, Diana C., Kelsell, David P.

“…The palmoplantar epidermis is a specialized area of the skin that undergoes high levels of mechanical stress. The palmoplantar keratinization and esophageal…”
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Coastal upwelling drives ecosystem temporal variability from the surface to the abyssal seafloor by Messié, Monique, Sherlock, Rob E, Huffard, Christine L, Pennington, J Timothy, Choy, C Anela, Michisaki, Reiko P, Gomes, Kevin, Chavez, Francisco P, Robison, Bruce H, Smith, Jr, Kenneth L

“…Long-term biological time series that monitor ecosystems across the ocean's full water column are extremely rare. As a result, classic paradigms are yet to be…”
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The ClosTron: A universal gene knock-out system for the genus Clostridium by Heap, John T., Pennington, Oliver J., Cartman, Stephen T., Carter, Glen P., Minton, Nigel P.

“…Progress in exploiting clostridial genome information has been severely impeded by a general lack of effective methods for the directed inactivation of…”
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The ADAM metalloproteinases by Edwards, Dylan R., Handsley, Madeleine M., Pennington, Caroline J.

“…The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell…”
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Seawater sampling by an autonomous underwater vehicle: "Gulper" sample validation for nitrate, chlorophyll, phytoplankton, and primary production by Pennington, J. T., Blum, M., Chavez, F. P.

“…The effort and expense associated with sample and data collections for long oceanographic time series are, in part, driving the development of autonomous…”
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Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits by Sanz, Marta, Mann, Brendan T, Ryan, Paul L, Bosque, Alberto, Pennington, Daniel J, Hackstein, Holger, Soriano-Sarabia, Natalia

“…Under non-pathological conditions, human γδ T cells represent a small fraction of CD3 T cells in peripheral blood (1-10%). They constitute a unique subset of T…”
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