Search Results - "Pennings, Sebastiaan W.C."

Curcumin induces differential expression of cytoprotective enzymes but similar apoptotic responses in fibroblasts and myofibroblasts by Lundvig, Ditte M.S., Pennings, Sebastiaan W.C., Brouwer, Katrien M., Mtaya-Mlangwa, Matilda, Mugonzibwa, Emeria A., Kuijpers-Jagtman, Anne Marie, Von den Hoff, Johannes W., Wagener, Frank A.D.T.G.

“…Excessive extracellular matrix (ECM) deposition and tissue contraction after injury can lead to esthetic and functional problems. Fibroblasts and…”
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Cytoprotective responses in HaCaT keratinocytes exposed to high doses of curcumin by Lundvig, Ditte M.S., Pennings, Sebastiaan W.C., Brouwer, Katrien M., Mtaya-Mlangwa, Matilda, Mugonzibwa, Emeria, Kuijpers-Jagtman, Anne Marie, Wagener, Frank A.D.T.G., Von den Hoff, Johannes W.

“…Wound healing is a complex process that involves the well-coordinated interactions of different cell types. Topical application of high doses of curcumin, a…”
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Erythropoietin Attenuates Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension through Interplay between Endothelial Progenitor Cells and Heme Oxygenase by van Loon, Rosa Laura E, Bartelds, Beatrijs, Wagener, Frank A D T G, Affara, Nada, Mohaupt, Saffloer, Wijnberg, Hans, Pennings, Sebastiaan W C, Takens, Janny, Berger, Rolf M F

“…Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions…”
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DNA methylation immediately adjacent to active histone marking does not silence transcription by Brinkman, Arie B, Pennings, Sebastiaan W.C, Braliou, Georgia G, Rietveld, Luc E.G, Stunnenberg, Hendrik G

“…Active promoters generally contain histone H3/H4 hyperacetylation and tri-methylation at H3 lysine 4, whereas repressed promoters are associated with DNA…”
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Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis by Scharstuhl, Alwin, Mutsaers, Henricus A M, Pennings, Sebastiaan W C, Russel, Frans G M, Wagener, Frank A D T G

“…We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated…”
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Histone modification patterns associated with the human X chromosome by Brinkman, Arie B, Roelofsen, Thijs, Pennings, Sebastiaan W C, Martens, Joost H A, Jenuwein, Thomas, Stunnenberg, Hendrik G

“…X inactivation is associated with chromosome‐wide establishment of inactive chromatin. Although this is classically regarded as facultative heterochromatin…”
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Delayed cutaneous wound closure in HO‐2 deficient mice despite normal HO‐1 expression by Lundvig, Ditte M. S., Scharstuhl, Alwin, Cremers, Niels A. J., Pennings, Sebastiaan W. C., Paske, Jeroen, Rheden, René, Run‐van Breda, Coby, Regan, Raymond F., Russel, Frans G. M., Carels, Carine E., Maltha, Jaap C., Wagener, Frank A. D. T. G.

“…Impaired wound healing can lead to scarring, and aesthetical and functional problems. The cytoprotective haem oxygenase (HO) enzymes degrade haem into iron,…”
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Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study by Dekker, Douwe, Dorresteijn, Mirrin J, Peters, Wilbert Hm, Bilos, Albert, Pennings, Sebastiaan W C, Wagener, Frank A D T G, Smits, Paul

“…This translational randomized and vehicle-controlled cross-over study was performed to assess the impact of haem arginate treatment on haem oxygenase-1…”
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