Search Results - "Penning, Trevor M"

Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons by Penning, Trevor M

“…Aldo-keto reductases (AKRs) are promiscuous NAD­(P)­(H) dependent oxidoreductases implicated in the metabolic activation of polycyclic aromatic hydrocarbons…”
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Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis by Penning, Trevor M

“…Human aldo-keto reductases (AKRs) are NAD­(P)­H-dependent oxidoreductases that convert aldehydes and ketones to primary and secondary alcohols for subsequent…”
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Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review by Penning, Trevor M

“…AKR1C3 is a drug target in hormonal and hormonal independent malignancies and acts as a major peripheral 17β-hydroxysteroid dehydrogenase to yield the potent…”
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Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes by Penning, Trevor M, Wangtrakuldee, Phumvadee, Auchus, Richard J

“…Abstract Aldo-keto reductases (AKRs) are monomeric NAD(P)(H)-dependent oxidoreductases that play pivotal roles in the biosynthesis and metabolism of steroids…”
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Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism by Rižner, Tea Lanišnik, Penning, Trevor M.

“…•The aldo–keto reductase superfamily contains five human steroid-metabolizing enzymes.•AKR1C isoforms act as 3-, 17- and 20-ketosteroid reductases.•AKR1D1 is…”
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Aldo-keto reductases and bioactivation/detoxication by YI JIN, PENNING, Trevor M

“…Aldo-keto reductases (AKRs) are soluble NAD(P)(H) oxidoreductases that primarily reduce aldehydes and ketones to primary and secondary alcohols, respectively…”
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Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes by Paulukinas, Ryan D, Mesaros, Clementina A, Penning, Trevor M

“…Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women. A common symptom of PCOS is hyperandrogenism (AE); however, the source of these…”
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5β-Dihydrosteroids: Formation and Properties by Penning, Trevor M, Covey, Douglas F

“…5β-Dihydrosteroids are produced by the reduction of Δ -3-ketosteroids catalyzed by steroid 5β-reductase (AKR1D1). By analogy with steroid 5α-reductase, genetic…”
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Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer by Knudsen, Karen E, Penning, Trevor M

“…Prostate cancer remains a leading cause of cancer death, as there are no durable means to treat advanced disease. Treatment of non-organ-confined prostate…”
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AKR1C3 as a target in castrate resistant prostate cancer by Adeniji, Adegoke O., Chen, Mo, Penning, Trevor M.

“…•Superior therapeutic agents to Abiraterone and Enzalutamide are required to treat CRPC.•AKR1C3 synthesizes potent ligands for the androgen receptor…”
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Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) by Detlefsen, Andrea J., Wangtrakuldee, Phumvadee, Penning, Trevor M.

“…Aldo-keto reductase (AKR) 1C3, also known as type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase, is a member of the AKR superfamily that…”
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Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes by Poutanen, Matti, Penning, Trevor M.

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Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms by Penning, Trevor M., Drury, Jason E.

“…Aldo–keto reductases (AKRs) are a superfamily of NAD(P)H linked oxidoreductases that are generally monomeric 34–37kDa proteins present in all phyla. The…”
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Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases by Detlefsen, Andrea J, Paulukinas, Ryan D, Penning, Trevor M

“…Steroid hormones synchronize a variety of functions throughout all stages of life. Importantly, steroid hormone-transforming enzymes are ultimately responsible…”
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Steroid Hormone Transforming Aldo-Keto Reductases and Cancer by Penning, Trevor M., Byrns, Michael C.

“…Prostate and breast cancer are hormone‐dependent malignancies of the aging male and female and require the local production of androgens and estrogens to…”
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Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3‑Nitrobenzanthrone in Human Lung Cells by Murray, Jessica R, de la Vega, Laureano, Hayes, John D, Duan, Ling, Penning, Trevor M

“…3-Nitrobenzanthrone (3-NBA) is a suspected human carcinogen present in diesel exhaust. It requires metabolic activation via nitroreduction in order to form DNA…”
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Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer by Mostaghel, Elahe A, Zhang, Ailin, Hernandez, Susana, Marck, Brett T, Zhang, Xiaotun, Tamae, Daniel, Biehl, Heather E, Tretiakova, Maria, Bartlett, Jon, Burns, John, Dumpit, Ruth, Ang, Lisa, Matsumoto, Alvin M, Penning, Trevor M, Balk, Steven P, Morrissey, Colm, Corey, Eva, True, Lawrence D, Nelson, Peter S

“…Tumor androgens in castration-resistant prostate cancer (CRPC) reflect intratumoral synthesis or adrenal androgens. We used C.B.-17 SCID mice in which we…”
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AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease by Nikolaou, Nikolaos, Gathercole, Laura L., Marchand, Lea, Althari, Sara, Dempster, Niall J., Green, Charlotte J., van de Bunt, Martijn, McNeil, Catriona, Arvaniti, Anastasia, Hughes, Beverly A., Sgromo, Bruno, Gillies, Richard S., Marschall, Hanns-Ulrich, Penning, Trevor M., Ryan, John, Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.

“…Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators of hepatic…”
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The aldo-keto reductases (AKRs): Overview by Penning, Trevor M.

“…[Display omitted] •Aldo-keto reductases (AKRs) are a major superfamily of NAD(P)H-dependent oxidoreductases.•They use a conserved catalytic mechanism and rate…”
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AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells by Verma, Kshitij, Gupta, Nehal, Zang, Tianzhu, Wangtrakluldee, Phumvadee, Srivastava, Sanjay K, Penning, Trevor M, Trippier, Paul C

“…Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing…”
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