Search Results - "Penner‐Hahn, James E."

Co(II) Substitution Enhances the Esterase Activity of a de Novo Designed Zn(II) Carbonic Anhydrase by Borghesani, Valentina, Zastrow, Melissa L., Tolbert, Audrey E., Deb, Aniruddha, Penner‐Hahn, James E., Pecoraro, Vincent L.

“…Carbonic Anhydrases (CAs) have been a target for de novo protein designers due to the simplicity of the active site and rapid rate of the reaction. The first…”
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A De Novo Designed Metalloenzyme for the Hydration of CO2 by Cangelosi, Virginia M., Deb, Aniruddha, Penner-Hahn, James E., Pecoraro, Vincent L.

“…Protein design will ultimately allow for the creation of artificial enzymes with novel functions and unprecedented stability. To test our current mastery of…”
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Making or Breaking Metal‐Dependent Catalytic Activity: The Role of Stammers in Designed Three‐Stranded Coiled Coils by Pinter, Tyler B. J., Manickas, Elizabeth C., Tolbert, Audrey E., Koebke, Karl J., Deb, Aniruddha, Penner‐Hahn, James E., Pecoraro, Vincent L.

“…While many life‐critical reactions would be infeasibly slow without metal cofactors, a detailed understanding of how protein structure can influence catalytic…”
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Rational De Novo Design of a Cu Metalloenzyme for Superoxide Dismutation by Mathieu, Emilie, Tolbert, Audrey E., Koebke, Karl J., Tard, Cédric, Iranzo, Olga, Penner‐Hahn, James E., Policar, Clotilde, Pecoraro, Vincent

“…Superoxide dismutases (SODs) are highly efficient enzymes for superoxide dismutation and the first line of defense against oxidative stress. These…”
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Modifying the Steric Properties in the Second Coordination Sphere of Designed Peptides Leads to Enhancement of Nitrite Reductase Activity by Koebke, Karl J., Yu, Fangting, Salerno, Elvin, Van Stappen, Casey, Tebo, Alison G., Penner‐Hahn, James E., Pecoraro, Vincent L.

“…Protein design is a useful strategy to interrogate the protein structure‐function relationship. We demonstrate using a highly modular 3‐stranded coiled coil…”
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Coencapsulation of Arsenic- and Platinum-based Drugs for Targeted Cancer Treatment by Chen, Haimei, Pazicni, Samuel, Krett, Nancy L, Ahn, Richard W, Penner-Hahn, James E, Rosen, Steven T, O'Halloran, Thomas V

“…Two in one: A novel strategy for efficiently coencapsulating both arsenic‐ and platinum‐based drugs into 100 nm‐scale liposomes (NBs) relies on the formation…”
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Designing a functional type 2 copper center that has nitrite reductase activity within α-helical coiled coils by Tegoni, Matteo, Yu, Fangting, Bersellini, Manuela, Penner-Hahn, James E., Pecoraro, Vincent L.

“…One of the ultimate objectives of de novo protein design is to realize systems capable of catalyzing redox reactions on substrates. This goal is challenging as…”
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Polarized XANES Monitors Femtosecond Structural Evolution of Photoexcited Vitamin B12 by Miller, Nicholas A, Deb, Aniruddha, Alonso-Mori, Roberto, Garabato, Brady D, Glownia, James M, Kiefer, Laura M, Koralek, Jake, Sikorski, Marcin, Spears, Kenneth G, Wiley, Theodore E, Zhu, Diling, Kozlowski, Pawel M, Kubarych, Kevin J, Penner-Hahn, James E, Sension, Roseanne J

“…Ultrafast, polarization-selective time-resolved X-ray absorption near-edge structure (XANES) was used to characterize the photochemistry of vitamin B12,…”
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Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide by Brender, Jeffrey R, Krishnamoorthy, Janarthanan, Messina, Grazia M L, Deb, Aniruddha, Vivekanandan, Subramanian, La Rosa, Carmelo, Penner-Hahn, James E, Ramamoorthy, Ayyalusamy

“…The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been…”
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Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein by Koebke, Karl J, Ruckthong, Leela, Meagher, Jennifer L, Mathieu, Emilie, Harland, Jill, Deb, Aniruddha, Lehnert, Nicolai, Policar, Clotilde, Tard, Cédric, Penner-Hahn, James E, Stuckey, Jeanne A, Pecoraro, Vincent L

“…Cupredoxins are copper-dependent electron-transfer proteins that can be categorized as blue, purple, green, and red depending on the spectroscopic properties…”
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Tetrathiomolybdate Inhibits Copper Trafficking Proteins through Metal Cluster Formation by Alvarez, Hamsell M., Xue, Yi, Robinson, Chandler D., Canalizo-Hernández, Mónica A., Marvin, Rebecca G., Kelly, Rebekah A., Mondragón, Alfonso, Penner-Hahn, James E., O'Halloran, Thomas V.

“…Tetrathiomolybdate (TM) is an orally active agent for treatment of disorders of copper metabolism. Here we describe how TM inhibits proteins that regulate…”
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Elucidating the Protonation Site of Vanadium Peroxide Complexes and the Implications for Biomimetic Catalysis by Schneider, Curtis J, Penner-Hahn, James E, Pecoraro, Vincent L

“…Coordination complexes of vanadium(5+) played a key role in understanding the structure and mechanism of vanadium-dependent haloperoxidases, particularly the…”
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Understanding Spin Structure in Metallacrown Single-Molecule Magnets using Magnetic Compton Scattering by Deb, Aniruddha, Boron, Thaddeus T, Itou, Masayoshi, Sakurai, Yoshiharu, Mallah, Talal, Pecoraro, Vincent L, Penner-Hahn, James E

“…The 3d–4f mixed metallacrowns frequently show single-molecule magnetic behavior. We have used magnetic Compton scattering to characterize the spin structure…”
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The Interaction of Mitochondrial Iron with Manganese Superoxide Dismutase by Naranuntarat, Amornrat, Jensen, Laran T., Pazicni, Samuel, Penner-Hahn, James E., Culotta, Valeria C.

“…Superoxide dismutase 2 (SOD2) is one of the rare mitochondrial enzymes evolved to use manganese as a cofactor over the more abundant element iron. Although…”
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Peptidic models for the binding of Pb(II), Bi(III) and Cd(II) to mononuclear thiolate binding sites by Matzapetakis, Manolis, Ghosh, Debdip, Weng, Tsu-Chien, Penner-Hahn, James E, Pecoraro, Vincent L

“…Herein, we evaluate the binding of Pb(II) and Bi(III) to cysteine-substituted versions of the TRI peptides [AcG-(LKALEEK)4G-NH2] which have previously been…”
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Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma by DeToma, Alaina S., Dengler-Crish, Christine M., Deb, Aniruddha, Braymer, Joseph J., Penner-Hahn, James E., van der Schyf, Cornelis J., Lim, Mi Hee, Crish, Samuel D.

“…The purpose of this study was to determine metal ion levels in central visual system structures of the DBA/2J mouse model of glaucoma. We used inductively…”
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Making or Breaking Metal‐Dependent Catalytic Activity: The Role of Stammers in Designed Three‐Stranded Coiled Coils by Pinter, Tyler B. J., Manickas, Elizabeth C., Tolbert, Audrey E., Koebke, Karl J., Deb, Aniruddha, Penner‐Hahn, James E., Pecoraro, Vincent L.

“…While many life‐critical reactions would be infeasibly slow without metal cofactors, a detailed understanding of how protein structure can influence catalytic…”
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A method for normalization of X-ray absorption spectra by Weng, Tsu-Chien, Waldo, Geoffrey S, Penner-Hahn, James E

“…Accurate normalization of X-ray absorption data is essential for quantitative analysis of near-edge features. A method, implemented as the program MBACK, to…”
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Ballistic excited state dynamics revealed by polarized fs-XANES by Sension, Roseanne J., Miller, Nicholas A., Deb, Aniruddha, Alonso-Mori, Roberto, Glownia, James M., Penner-Hahn, James E.

“…Polarized time-resolved X-ray absorption near edge structure (XANES) is used to characterize the sequential ballistic excited state dynamics of two B 12…”
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NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P by Koutmou, Kristin S, Casiano-Negroni, Anette, Getz, Melissa M, Pazicni, Samuel, Andrews, Andrew J, Penner-Hahn, James E, Al-Hashimi, Hashim M, Fierke, Carol A

“…Functionally critical metals interact with RNA through complex coordination schemes that are currently difficult to visualize at the atomic level under…”
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