Search Results - "Pennarun, Bodvael"

Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells by Bucur, Octavian, Stancu, Andreea Lucia, Goganau, Ioana, Petrescu, Stefana Maria, Pennarun, Bodvael, Bertomeu, Thierry, Dewar, Rajan, Khosravi-Far, Roya

“…Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new…”
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Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL by Pennarun, Bodvael, Kleibeuker, Jan H, van Ek, Wytske Boersma, Kruyt, Frank AE, Hollema, Harry, de Vries, Elisabeth GE, de Jong, Steven

“…The multikinase inhibitor sorafenib is highly effective against certain types of cancer in the clinic and prevents colon cancer cell proliferation in vitro…”
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Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5 by van Geelen, Caroline Mm, Pennarun, Bodvael, Le, Phuong Tk, de Vries, Elisabeth Ge, de Jong, Steven

“…rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5…”
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Playing the DISC: Turning on TRAIL death receptor-mediated apoptosis in cancer by Pennarun, Bodvaël, Meijer, Annemieke, de Vries, Elisabeth G.E., Kleibeuker, Jan H., Kruyt, Frank, de Jong, Steven

“…Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related…”
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Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL by Pennarun, Bodvael, Kleibeuker, Jan H, Oenema, Tjitske, Stegehuis, Janet H, de Vries, Elisabeth G E, de Jong, Steven

“…BACKGROUNDtumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors,…”
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A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death by Bucur, Octavian, Gaidos, Gabriel, Yatawara, Achani, Pennarun, Bodvael, Rupasinghe, Chamila, Roux, Jérémie, Andrei, Stefan, Guo, Bingqian, Panaitiu, Alexandra, Pellegrini, Maria, Mierke, Dale F., Khosravi-Far, Roya

“…Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR5) are currently being created for clinical cancer therapy, due to their…”
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Abstract 3058: miRNA networks mediate the tumor suppressive function of FOXO proteins by Nadler, Monica, Zabolian, Robin, Ndebele, Kenneth, bertomeu, thierry, Bucur, Octavian, Pennarun, Bodvael, Khosravi-Far, Roya

“…Abstract FOXO transcription factors, as regulators of a variety of cellular functions, including promotion of apoptotic cell death, are negatively regulated by…”
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Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP by Bucur, Octavian, Pennarun, Bodvael, Stancu, Andreea Lucia, Nadler, Monica, Muraru, Maria Sinziana, Bertomeu, Thierry, Khosravi-Far, Roya

“…Successful translation of findings derived from preclinical studies into effective therapies is critical in biomedical research. Lack of robustness and…”
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Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines by VAN GEELEN, Caroline M. M, PENNARUN, Bodvael, EK, Wytske Boerma-Van, LE, Phuong T. K, SPIERINGS, Diana C. J, DE VRIES, Elisabeth G. E, DE JONG, Steven

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers the apoptotic cascade in various colon cancer cell lines after binding to the membrane…”
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Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL by Pennarun, Bodvael, Kleibeuker, Jan H., Oenema, Tjitske, Stegehuis, Janet H., de Vries, Elisabeth G. E., de Jong, Steven

“…Background Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors,…”
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Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL by Pennarun, Bodvael, Kleibeuker, Jan H, Oenema, Tjitske, Stegehuis, Janet H, de Vries, Elisabeth G E, de Jong, Steven

“…tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death…”
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The Peroxidase PRDX1 Is Regulating FOXO3 Signaling in a Redox Dependent Manner by Hopkins, Barbara L, Nadler, Monica, Bertomeu, Thierry, Skoko, John, Pennarun, Bodvaël, Bucur, Octavian, Bryll, Alysia, Zaboulian, Robin, Ndebele, Kenneth, Khosravi-Far, Roya, Neumann, Carola

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299 - The Peroxidase PRDX1 Is Regulating FOXO3 Signaling in a Redox Dependent Manner by Hopkins, Barbara L, Nadler, Monica, Bertomeu, Thierry, Skoko, John, Pennarun, Bodvaël, Bucur, Octavian, Bryll, Alysia, Zaboulian, Robin, Ndebele, Kenneth, Khosravi-Far, Roya, Neumann, Carola

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