Search Results - "Pennacchi, Paula Comune"
-
1
A new reconstructed human epidermis for in vitro skin irritation testing
Published in Toxicology in vitro (01-08-2017)“…Different models of reconstructed human epidermis (RHE) are currently validated to assess skin irritation in vitro and ultimately to the animal replacement of…”
Get full text
Journal Article -
2
Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…This chapter presents the protocols for developing of skin equivalents (SE) and reconstructed human epidermis (RHE) models for dermal toxicity evaluation as an…”
Get more information
Journal Article -
3
Passiflora edulis Leaf Extract: Evidence of Antidiabetic and Antiplatelet Effects in Rats
Published in Biological & pharmaceutical bulletin (01-01-2020)“…Different Passiflora species have been appointed as a promising herbal medicine due to antioxidant properties; however, their effect on oxidative process…”
Get full text
Journal Article -
4
763 Expanded and activated TILs kill tumor cells enabling IO compound assays
Published in Journal for immunotherapy of cancer (01-11-2020)“…BackgroundThe Tumor Microenvironment (TME) has a key role in solid tumor therapy screening. We have developed a 3D ex vivo immunosuppressive assay mimicking…”
Get full text
Journal Article -
5
WU-NK-101, an enhanced memory natural killer (NK) cell therapy, with cetuximab (Ctx) for the treatment of advanced colorectal cancer (CRC)
Published in Journal of clinical oncology (01-02-2023)“…170 Background: CRC is the 4 th leading cause of global cancer-related deaths, and novel therapeutic strategies for advanced CRC are urgently needed. Adoptive…”
Get full text
Journal Article -
6
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation
Published in Pharmacological research (01-09-2016)“…[Display omitted] The BRAFV600E mutation confers constitutive kinase activity and accounts for >90% of BRAF mutations in melanoma. This genetic alteration is a…”
Get full text
Journal Article -
7
-
8
Skin corrosion test: a comparison between reconstructed human epidermis and full thickness skin models
Published in European journal of pharmaceutics and biopharmaceutics (01-04-2018)“…[Display omitted] Currently, there is a strong global trend towards the development of in vitro models to replace the use of animals in safety evaluation…”
Get full text
Journal Article -
9
Glycated Reconstructed Human Skin as a Platform to Study the Pathogenesis of Skin Aging
Published in Tissue engineering. Part A (01-09-2015)“…The advanced glycation end products (AGEs) of proteins are common factors in the pathophysiology of a number of disorders related to aging. The skin generation…”
Get more information
Journal Article -
10
Fibroblasts protect melanoma cells from the cytotoxic effects of doxorubicin
Published in Tissue engineering. Part A (01-09-2014)“…Melanoma is the most aggressive form of skin cancer and until recently, it was extremely resistant to radio-, immuno-, and chemotherapy. Despite the latest…”
Get more information
Journal Article -
11
Abstract 4669: Targeting hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Abstract Melanoma represents the deadliest of all skin cancers being responsible for more than 75% of skin cancer-related deaths. Although the results with…”
Get full text
Journal Article -
12
Passiflora edulis leaf extract: evidence of antidiabetic and antiplatelet effects in rats
Published in Biological and Pharmaceutical Bulletin (2019)“…Different Passiflora species have been appointed as a promising herbal medicine due to antioxidant properties; however, their effect on oxidative process…”
Get full text
Journal Article