Acetone extract from Streptoverticillium sp., a bacterium isolated from Brazilian Cerrado soil, induces anti-inflammatory activity in mice

The Streptoverticillium sp. Z1 is an actinomycete isolated from the soil under Cerrado vegetation, the extract of this strain was investigated in nociceptive and inflammatory models. The Streptoverticillium extract (ExS) 50 and 100 mg/kg (s.c.) produced a significant inhibition of acetic acid-induce...

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Bibliographic Details
Published in:	Anais da Academia Brasileira de Ciências Vol. 85; no. 2; pp. 595 - 603
Main Authors:	Da Cruz, Rodrigo B, Galdino, Pablinny M, Penna, Karlla G B D, Hoffmann, Karen, Costa, Elson A, Bataus, Luiz A M
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 01-06-2013
Subjects:	Acetone - isolation & purification Acetone - therapeutic use Analgesics - isolation & purification Analgesics - therapeutic use Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - therapeutic use Carrageenan Croton Oil Edema - chemically induced Edema - drug therapy efeito anti-inflamatorio fosfolipase A2 Male Mice modelos de inflamacao e nocicepcao MULTIDISCIPLINARY SCIENCES Pain - chemically induced Pain - drug therapy Soil Microbiology Streptomycetaceae - chemistry Streptoverticillium phospholipase A2 activity fosfolipase A2 Streptoverticillium anti-inflammatory effect modelos de inflamacao e nocicepcao nociceptive and inflammatory models efeito anti-inflamatorio
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Summary:	The Streptoverticillium sp. Z1 is an actinomycete isolated from the soil under Cerrado vegetation, the extract of this strain was investigated in nociceptive and inflammatory models. The Streptoverticillium extract (ExS) 50 and 100 mg/kg (s.c.) produced a significant inhibition of acetic acid-induced abdominal writhings thereby demonstrating an anti-nociceptive effect. In the tail flick test the ExS (s.c.) was inactive. This result implited that ExS does not contain opioid-like compounds with central analgesic properties. In the inflammatory models, ExS 100 and 200 mg/kg (s.c.) were able to inhibit the croton oil-induced ear edema and, ExS 200 and 500 mg/kg (s.c.) inhibited the leukocyte migration on the carrageenan-induced peritonitis. The phospholipase A2 enzymatic assay showed that the anti-inflammatory activity of ExS was not due to direct effect on phospholipase A2 activity. These data suggest that Streptoverticillium sp. produces metabolites with anti-inflammatory effect and that these metabolites are unable to directly inhibit phospholipase A2 enzyme.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690 0001-3765
DOI:	10.1590/S0001-37652013000200009