Search Results - "Penman, Sophie L"

Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury by Waddington, James C, Ali, Serat-E, Penman, Sophie L, Whitaker, Paul, Hamlett, Jane, Chadwick, Amy, Naisbitt, Dean J, Park, B. Kevin, Meng, Xiaoli

“…Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver reactions. Although expression of HLA-B*57:01 increases…”
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Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells by Penman, Sophie L., Sharma, Parveen, Aerts, Hélène, Park, B. Kevin, Weaver, Richard J., Chadwick, Amy E.

“…Bile acids (BAs) are recognised as the causative agents of toxicity in drug-induced cholestasis (DIC). Research in isolated mitochondria and HepG2 cells have…”
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Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity by Penman, Sophie L, Carter, Alice S, Chadwick, Amy E

“…The mitochondrion is an essential organelle responsible for generating cellular energy. Additionally, mitochondria are a source of inter-individual variation…”
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First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug by Pieren, Michel, Abáigar Gutiérrez-Solana, Ana, Antonijoan Arbós, Rosa María, Boyle, Gary W, Davila, Myriam, Davy, Maria, Gitzinger, Marc, Husband, Lisa, Martínez-Martínez, María S, Mazarro, Dolores Ochoa, Pefani, Eleni, Penman, Sophie L, Remuiñán, Modesto J, Vlasakakis, Georgios, Zeitlinger, Markus, Dale, Glenn E

“…The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. A Phase 1,…”
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A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial by Diacon, Andreas H., Barry, Clifton E., Carlton, Alex, Chen, Ray Y., Davies, Matt, de Jager, Veronique, Fletcher, Kim, Koh, Gavin C. K. W., Kontsevaya, Irina, Heyckendorf, Jan, Lange, Christoph, Reimann, Maja, Penman, Sophie L., Scott, Rhona, Maher-Edwards, Gareth, Tiberi, Simon, Vlasakakis, Georgios, Upton, Caryn M., Aguirre, David Barros

“…New tuberculosis treatments are needed to address drug resistance, lengthy treatment duration and adverse reactions of available agents. GSK3036656…”
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Safety perspectives on presently considered drugs for the treatment of COVID‐19 by Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.

“…Intense efforts are underway to evaluate potential therapeutic agents for the treatment of COVID‐19. In order to respond quickly to the crisis, the repurposing…”
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Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models by Jones, Samantha W., Penman, Sophie L., French, Neil S., Park, B. Kevin, Chadwick, Amy E.

“…Inhibition of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzymatic step in de novo pyrimidine synthesis, has broad immunosuppressive effects in…”
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The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine by Jolly, Carol E., Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E., Beckett, Alison J., Penman, Sophie L., Williams, Dominic P., Monshouwer, Mario, Simic, Damir, Snoeys, Jan, Park, B. Kevin, Chadwick, Amy E.

“…During its clinical development fialuridine caused liver toxicity and the death of five patients. This case remains relevant due to the continued development…”
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The mitochondrial paradox by Penman, Sophie L, Jensen, Rebecca L, Kiy, Robyn T, Chadwick, Amy E

“…A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs…”
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