Search Results - "Penman, B W"

DNA Damage and Mutation in Human Cells Exposed to Nitric Oxide in vitro by Nguyen, T., Brunson, D., Crespi, C. L., Penman, B. W., Wishnok, J. S., Tannenbaum, S. R.

“…Nitric oxide (NO·) is a physiological messenger formed by several cell types. Reaction with O2forms oxides that nitrosate amines at pH values near 7. We now…”
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Human Cytochrome P4502B6. Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation by CODE, E. L, CRESPI, C. L, PENMAN, B. W, GONZALEZ, F. J, CHANG, T. K. H, WAXMAN, D. J

“…The level of expression and interindividual variation in human hepatic microsomal cytochrome P450 (CYP) 2B6 was characterized using a polyclonal antibody…”
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Bioassay-Directed Chemical Analysis of Los Angeles Airborne Particulate Matter Using a Human Cell Mutagenicity Assay by Hannigan, Michael P, Cass, Glen R, Penman, Bruce W, Crespi, Charles L, Lafleur, Arthur L, Busby, William F, Thilly, William G, Simoneit, Bernd R. T

“…The human cell mutagenicity of Los Angeles airborne fine particulate matter is examined via bioassay-directed chemical analysis. A 1993 composite fine particle…”
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Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens by Crespi, Charles L., W-Penman, Bruce, Steimel, Dorothy T., Smith, Theresa, Yang, Chung S., Sutter, Thomas R.

“…An AHH-1 TK+/− cell derivative was developed that stably expresses human cytochrome P4501B1 (CYP1B1) cDNA in an extrachromosomal vector which confers…”
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A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6 by Crespi, C L, Penman, B W, Gelboin, H V, Gonzalez, F J

“…We have developed a human B-lymphoblastoid cell line, designated 2D6/Hol, which stably expresses human cytochrome P450 CYP2D6 cDNA. This cell line exhibits…”
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Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase by MING HU, YIQI LI, DAVITT, C. M, HUANG, S.-M, THUMMEL, K, PENMAN, B. W, CRESPI, C. L

“…To further characterize CYP3A4-transfected Caco-2 cells with regard to morphological, transport, and metabolic properties, and to evaluate a different Caco-2…”
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Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450 by Crespi, Charles L., Miller, Vaughn P., Penman, Bruce W.

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Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450 by Crespi, C L, Langenbach, R, Penman, B W

“…We are developing a panel of human B lymphoblastoid cells which have been engineered to express specific human cDNAs for cytochrome P450 and other xenobiotic…”
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The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3 by Crespi, C L, Penman, B W, Steimel, D T, Gelboin, H V, Gonzalez, F J

“…We have developed a human lymphoblastoid cell line, designated 3A4/Hol, which stably expresses human CYP3A4 cDNA. This cell line exhibited testosterone 6…”
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Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens by Penman, B W, Chen, L, Gelboin, H V, Gonzalez, F J, Crespi, C L

“…AHH-1 TK+/- cell derivatives were developed that stably express human CYP1A1 cDNA, and an AHH-1 TK+/- derivative expressing higher levels of CYP1A2 cDNA in…”
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Coexpression of Cytochrome P4502A6 and Human NADPH-P450 Oxidoreductase in the Baculovirus System by CHEN, L, BUTERS, J. T. M, HARDWICK, J. P, TAMURA, S, PENMAN, B. W, GONZALEZ, F. J, CRESPI, C. L

“…Heterologous expression using baculovirus vectors has become a popular method for the production of catalytically active cytochrome P450s (CYPs). We have…”
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Human Cell Mutagens in Los Angeles Air by Hannigan, Michael P, Cass, Glen R, Penman, Bruce W, Crespi, Charles L, Lafleur, Arthur L, Busby, William F, Thilly, William G

“…The human cell mutagenicity of particulate air pollution samples collected in southern California is measured. The human cell mutation assay used in this study…”
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Human-Cell Mutagens in Respirable Airborne Particles in the Northeastern United States. 1. Mutagenicity of Fractionated Samples by Pedersen, Daniel U., Durant, John L., Penman, Bruce W., Crespi, Charles L., Hemond, Harold F., Lafleur, Arthur L., Cass, Glen R.

“…Few studies have characterized the regional scale (300−500 km) variability of the mutagenicity of respirable airborne particles (PM2.5). We previously…”
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Genetic toxicology using human cell lines expressing human P-450 by Crespi, C L, Penman, B W, Gonzalez, F J, Gelboin, H V, Galvin, M, Langenbach, R

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Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4 by Crespi, C L, Penman, B W, Hu, M

“…To develop Caco-2 cell derivatives expressing high levels of human cytochrome P450 drug metabolizing enzymes. The cDNAs for two cytochrome P450 forms, CYP2A6…”
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A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing by Crespi, Charles L, Gonzalez, Frank J, Steimel, Dorothy T, Turner, Thomas R, Gelboin, Harry V, Penman, Bruce W, Langenbach, Robert

“…A human B-lymphoblastoid cell line, designated MCL-5, constitutively expressing human cytochrome P-450 CYP1A1 and also expressing five transfected human cDNAs…”
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Sodium fluoride is a less efficient human cell mutagen at low concentrations by Crespi, C L, Seixas, G M, Turner, T, Penman, B W

“…Sodium fluoride was found to induce gene-locus mutations at the thymidine kinase (tk) and hypoxanthine guanine phosphoribosyl transferase (hgprt) loci in human…”
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Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6 by Penman, B W, Reece, J, Smith, T, Yang, C S, Gelboin, H V, Gonzalez, F J, Crespi, C L

“…We have developed a human B-lymphoblastoid cell, designated h2D6v2, which expresses high levels of CYP2D6 cDNA. Microsomal P450 contents of 160 pmol mg-1…”
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Human cell mutagenicity of chlorinated and unchlorinated water and the disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5 H)-furanone (MX) by Woodruff, Nathaniel W, Durant, John L, Donhoffner, Lawrence L, Crespi, Charles L, Penman, Bruce W

“…Extracts of three water samples — humic acid-enriched water-both peatland water and drinking water, both with and without chlorination were tested for…”
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The induction of aneuploidy by nitrogen mustard in a human lymphoblastoid cell line by Crespi, C L, Seixas, G M, Penman, B W

“…We report that the presence of an extra Y chromosome can be used as a marker for the induction of aneuploidy (mitotic non-disjunction) in a human…”
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