Search Results - "Penley, McKenna"

Gene flow accelerates adaptation to a parasite by Lewis, Jordan A, Kandala, Prathyusha, Penley, McKenna J, Morran, Levi T

“…Gene flow into populations can increase additive genetic variation and introduce novel beneficial alleles, thus facilitating adaptation. However, gene flow may…”
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Host genetic drift and adaptation in the evolution and maintenance of parasite resistance by White, P. Signe, Arslan, Danial, Kim, David, Penley, McKenna, Morran, Levi

“…Host–parasite interactions may often be subject to opposing evolutionary forces, which likely influence the evolutionary trajectories of both partners. Natural…”
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Evolution of Caenorhabditis elegans host defense under selection by the bacterial parasite Serratia marcescens by Penley, McKenna J, Ha, Giang T, Morran, Levi T

“…Parasites can impose strong selection on hosts. In response, some host populations have adapted via the evolution of defenses that prevent or impede infection…”
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Associations of Evolutionary-Concordance Diet and Lifestyle Pattern Scores with Incident, Sporadic Colorectal Adenoma in a Pooled Case-Control Study by Penley, McKenna J., Byrd, Doratha A., Bostick, Roberd M.

“…Differences in diet and lifestyle relative to those of our Paleolithic-era ancestors may explain current high incidences of chronic diseases, including…”
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Prevention and Care Opportunities for People Who Inject Drugs in an HIV Outbreak — Kanawha County, West Virginia, 2019–2021 by Bonacci, Robert A., Moorman, Anne C., Bixler, Danae, Penley, McKenna, Wilson, Suzanne, Hudson, Alana, McClung, R. Paul

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The Integral Role of Genetic Variation in the Evolution of Outcrossing in the Caenorhabditis elegans-Serratia marcescens Host-Parasite System by Parrish, 2nd, Raymond C, Penley, McKenna J, Morran, Levi T

“…Outcrossing is predicted to facilitate more rapid adaptation than self-fertilization as a result of genetic exchange between genetically variable individuals…”
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The evolution of parasite host range in heterogeneous host populations by Gibson, Amanda K., Baffoe‐Bonnie, Helena, Penley, McKenna J., Lin, Julie, Owens, Raythe, Khalid, Arooj, Morran, Levi T.

“…Theory on the evolution of niche width argues that resource heterogeneity selects for niche breadth. For parasites, this theory predicts that parasite…”
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Dauer life stage of Caenorhabditis elegans induces elevated levels of defense against the parasite Serratia marcescens by White, P. Signe, Penley, McKenna J., Tierney, Aimee R. Paulk, Soper, Deanna M., Morran, Levi T.

“…Host-parasite research often focuses on a single host life stage, yet different life stages may exhibit different defenses. The nematode Caenorhabditis elegans…”
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No measurable fitness cost to experimentally evolved host defence in the Caenorhabditis elegans–Serratia marcescens host–parasite system by Penley, McKenna J., Greenberg, Arielle B., Khalid, Arooj, Namburar, Sathvik R., Morran, Levi T.

“…Host susceptibility to parasites can vary over space and time. Costs associated with the maintenance of host defence are thought to account for a portion of…”
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Assessment of Caenorhabditis elegans Competitive Fitness in the Presence of a Bacterial Parasite by Penley, McKenna J, Morran, Levi T

“…Accurate measurements of an organism's fitness are crucial for measuring evolutionary change. Methods of fitness measurement are most accurate when…”
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Sex and Mitonuclear Adaptation in Experimental Caenorhabditis elegans Populations by Wernick, Riana I, Christy, Stephen F, Howe, Dana K, Sullins, Jennifer A, Ramirez, Joseph F, Sare, Maura, Penley, McKenna J, Morran, Levi T, Denver, Dee R, Estes, Suzanne

“…To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with nematodes was conducted in which…”
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Clinicopathological features and survival outcomes of rare histologic variants of gallbladder cancer by Akce, Mehmet, Zakka, Katerina, Penley, McKenna, Jiang, Renjian, Alese, Olatunji B., Shaib, Walid L., Wu, Christina, Behera, Madhusmita, El‐Rayes, Bassel F.

“…Background Adenocarcinoma (AC) is the most common histological type in gallbladder carcinoma (GBC). Squamous cell carcinoma (SCC), adenosquamous carcinoma…”
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High parasite virulence necessary for the maintenance of host outcrossing via parasite-mediated selection by Slowinski, Samuel P, Cho, JaeHoon, Penley, McKenna J, Alexander, Laura W, Greenberg, Arielle B, Namburar, Sathvik R, Morran, Levi T

“…Biparental sex is widespread in nature, yet costly relative to uniparental reproduction. It is generally unclear why self-fertilizing or asexual lineages do…”
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Turnover in local parasite populations temporarily favors host outcrossing over self‐fertilization during experimental evolution by Lynch, Zachary R., Penley, McKenna J., Morran, Levi T.

“…The ubiquity of outcrossing in plants and animals is difficult to explain given its costs relative to self‐fertilization. Despite these costs, exposure to…”
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Nematode-bacteria mutualism: Selection within the mutualism supersedes selection outside of the mutualism by Morran, Levi T., Penley, McKenna J., Byrd, Victoria S., Meyer, Andrew J., O'Sullivan, Timothy S., Bashey, Farrah, Goodrich-Blair, Heidi, Lively, Curtis M.

“…The coevolution of interacting species can lead to codependent mutualists. Little is known about the effect of selection on partners within verses apart from…”
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A Novel Virulence Phenotype Rapidly Assesses Candida Fungal Pathogenesis in Healthy and Immunocompromised Caenorhabditis elegans Hosts by Feistel, Dorian J, Elmostafa, Rema, Nguyen, Nancy, Penley, McKenna, Morran, Levi, Hickman, Meleah A

“…The yeast is an opportunistic pathogen of humans, meaning that despite commensal interactions with its host, it can transition to a harmful pathogen. While is…”
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Corrigendum: Antagonistic Coevolution Limits the Range of Host Defense in C. elegans Populations by Lewis, Jordan A., Penley, McKenna J., Sylla, Hannan, Ahumada, Sebastián Durán, Morran, Levi T.

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Impact of high-risk features for stage II adenocarcinoma of the appendix by Akce, Mehmet, Zakka, Katerina, Penley, McKenna, Jiang, Renjian, Khalil, Lana, Alese, Olatunji B., Shaib, Walid L., Wu, Christina, Behera, Madhusmita, El-Rayes, Bassel F.

“…Clinico-pathological high-risk features are frequently utilized in adjuvant chemotherapy (AC) decisions in stage II colorectal cancer and their utility in…”
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Antagonistic Coevolution Limits the Range of Host Defense in C. elegans Populations by Lewis, Jordan A., Penley, McKenna J., Sylla, Hannan, Ahumada, Sebastián Durán, Morran, Levi T.

“…Host populations often evolve defenses against parasites due to the significant fitness costs imposed by infection. However, adaptation to a specific parasite…”
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Host heterogeneity mitigates virulence evolution by White, P Signe, Choi, Angela, Pandey, Rishika, Menezes, Arthur, Penley, McKenna, Gibson, Amanda K, de Roode, Jacobus, Morran, Levi

“…Parasites often infect genetically diverse host populations, and the evolutionary trajectories of parasite populations may be shaped by levels of host…”
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