Search Results - "Penland, R C"

Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation by Hsu, E W, Muzikant, A L, Matulevicius, S A, Penland, R C, Henriquez, C S

“…Functional properties of the myocardium are mediated by the tissue structure. Consequently, proper physiological studies and modeling necessitate a precise…”
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A flexible method for simulating cardiac conduction in three-dimensional complex geometries by Harrild, David M., Penland, R.Christian, Henriquez, Craig S.

“…In this article we present a method for creating a membrane-based computer model capable of representing a three-dimensional irregular domain. The spatial…”
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Modeling of fiber orientation in the ventricular myocardium with MR diffusion imaging by Sachse, F., Henriquez, C., Seemann, G., Riedel, C., Werner, C.D., Penland, R., Davis, B., Hsu, E.

“…A numerical simulation of the electrical and mechanical behavior of the heart requires appropriate anatomical models. Suitable for this are models that…”
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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation by Erdemli, Gül, Kim, Albert M, Ju, Haisong, Springer, Clayton, Penland, Robert C, Hoffmann, Peter K

“…The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced…”
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Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart by Bottino, Dean, Penland, R. Christian, Stamps, Andrew, Traebert, Martin, Dumotier, Bérengère, Georgieva, Anna, Helmlinger, Gabriel, Lett, G. Scott

“…Blockade of the delayed rectifier potassium channel current, I Kr, has been associated with drug-induced QT prolongation in the electrocardiogram and…”
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Using in silico biology to facilitate drug development by Levin, Jeremy M, Penland, R Christian, Stamps, Andrew T, Cho, Carolyn R

“…G protein-coupled receptor (GPCR) mediation of cardiac excitability is often overlooked in predicting the likelihood that a compound will alter repolarization…”
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Models for profiling the potential QT prolongation risk of drugs by Muzikant, Adam L, Penland, R Christian

“…The appearance of QT prolongation and arrhythmic events associated with a compound undergoing clinical trials can greatly hamper drug development programs…”
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