Search Results - "Penington, N. J."

Acute Ca2+ -dependent desensitization of 5-HT1A receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons by Yao, Y, Bergold, P.J, Penington, N.J

“…Abstract This report investigates acute changes in the sensitivity of 5-HT1A receptors in dorsal raphe (dr) neurons in response to elevated serotonin. DR…”
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Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat by Penington, N J, Kelly, J S, Fox, A P

“…1. An inwardly rectifying K+ current activated by serotonin (5-HT) was recorded from acutely isolated adult dorsal raphe (DR) neurones using the whole-cell…”
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A critical protein kinase C phosphorylation site on the 5-HT1A receptor controlling coupling to N-type calcium channels by Wu, X., Kushwaha, N., Albert, P. R., Penington, N. J.

“…The importance of specific protein kinase C (PKC) sites for modulation of the inhibitory coupling of 5-HT 1A receptors to N-type Ca 2+ channels was examined…”
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A study of the mechanism of Ca2+ current inhibition produced by serotonin in rat dorsal raphe neurons by Penington, NJ, Kelly, JS, Fox, AP

“…Calcium currents and their modulation by 5-HT were studied using both whole-cell and single-channel patch-clamp techniques in acutely isolated adult rat dorsal…”
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Effect of pertussis toxin and N-ethylmaleimide on voltage-dependent and -independent calcium current modulation in serotonergic neurons by Chen, Y, Yao, Y, Penington, N.J

“…Introduction of GTP-γ-S into a neuronal cell spontaneously results in G-protein activation. A possible contribution to this mechanism is that some receptors…”
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Differential effects of protein kinase C activation on 5-HT1A receptor coupling to Ca2+ and K+ currents in rat serotonergic neurones by Chen, Y, Penington, N J

“…1. Activation of the enzyme protein kinase C (PKC) partially uncouples receptors from the inhibition of Ca2+ current. We have studied the effect of PKC…”
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Unitary properties of potassium channels activated by 5-HT in acutely isolated rat dorsal raphe neurones by Penington, N J, Kelly, J S, Fox, A P

“…1. Single inwardly rectifying K+ channel currents were recorded from acutely isolated adult serotonergic dorsal raphe (DR) neurones using the cell-attached and…”
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Effects of LSD on Ca++ currents in central 5-HT-containing neurons: 5-HT1A receptors may play a role in hallucinogenesis by Penington, N J, Fox, A P

“…Drugs that influence the activity of central serotonergic neurons by activating a 5-hydroxytryptamine subtype of receptor (5-HT1A) alter mood and perception…”
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Actions of methoxylated amphetamine hallucinogens on serotonergic neurons of the brain by PENINGTON, N. J

“…1. Previous studies of phenethylamine hallucinogenic drugs have reported that intravenous injection of DOI or similar compounds produce an inhibition of the…”
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Ionic dependence of a slow inward tail current in rat dorsal raphe neurones by Penington, N J, Kelly, J S

“…1. The mechanism underlying a large slow inward tail current was studied in serotonergic dorsal raphe (DR) neurones. The tail current is most easily observed…”
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Lack of effect of antagonists on serotonin-induced inhibition in rat hippocampus by Penington, N J, Reiffenstein, R J

“…Four putative central nervous system 5-hydroxytryptamine antagonists, methysergide, cyproheptadine, metergoline, and ketanserin and also lysergic acid…”
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Possible involvement of serotonin receptors in the facilitatory effect of a hallucinogenic phenethylamine on single facial motoneurons by Penington, N J, Reiffenstein, R J

“…2,5-Dimethoxy-4-methylamphetamine (DOM, "STP") is a potent hallucinogen, proposed to be a serotonin receptor agonist. Its effects have not previously been…”
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ATP modulates Na + channel gating and induces a non-selective cation current in a neuronal hippocampal cell line by El-Sherif, Yasir, Wieraszko, Andrzej, Banerjee, Probal, Penington, Nicholas J

“…Extracellular ATP evoked two excitatory responses in hippocampal neuroblastoma cells (HN2). The first, an opening of a receptor-operated non-selective cation…”
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Toxin-insensitive Ca current in dorsal raphe neurons by Penington, NJ, Fox, AP

“…About 54% of the whole-cell Ca current recorded in dorsal raphe neurons cannot be categorized as N-, L-, or P-type Ca current. This current, ICa-Raphe, was not…”
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Agonist Stimulation of the Serotonin1A Receptor Causes Suppression of Anoxia‐Induced Apoptosis via Mitogen‐Activated Protein Kinase in Neuronal HN2‐5 Cells by Adayev, Tatyana, El‐Sherif, Yasir, Barua, Madhabi, Penington, Nicholas J., Banerjee, Probal

“…: Previous studies have indicated that stimulation of neuronal inhibitory receptors, such as the serotonin1A receptor (5‐HT1A‐R), could cause attenuation of…”
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Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron by Penington, N J, Kelly, J S

“…The release of serotonin (5-HT) from the terminals of serotonergic (raphe) neurons is under inhibitory feed-back control. 5-HT, acting on raphe cell body…”
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Order of Application Determines the Interaction Between Phorbol Esters and GTP-gamma -S in Dorsal Raphe Neurons: Evidence That the Effect of 5-HT Is Modified Upstream of the G Protein Ca Channel Interaction by Chen, Yuan, Penington, Nicholas J

“…Yuan Chen and Nicholas J. Penington Department of Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York, 11203…”
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Electrophysiology of adult rat facial motoneurones: the effects of serotonin (5-HT) in a novel in vitro brainstem slice by Larkman, P M, Penington, N J, Kelly, J S

“…Studies of adult rat motoneurones using in vitro slice preparations are rare. We here describe a novel brainstem slice of the adult rat containing the facial…”
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Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons by Yao, Y, Bergold, P J, Penington, N J

“…This report investigates acute changes in the sensitivity of 5-HT(1A) receptors in dorsal raphe (dr) neurons in response to elevated serotonin. DR neurons were…”
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Direct comparison of hallucinogenic phenethylamines and D-amphetamine on dorsal raphe neurons by Penington, N J, Reiffenstein, R J

“…We compared the effects of the hallucinogens 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline and the simulant D-amphetamine, applied by microiontophoresis…”
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