Search Results - "Penheiter, Alan R."

The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies by Penheiter, Alan R, Russell, Stephen J, Carlson, Stephanie K

“…Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-invasive imaging of reporter gene products to reveal the…”
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Unraveling the genomic underpinnings of unbalanced MYC break-apart FISH results using whole genome sequencing analysis by Gagnon, Marie-France, Penheiter, Alan R., Harris, Faye, Sadeghian, Dorsay, Johnson, Sarah H., Karagouga, Giannoula, McCune, Alexa, Zepeda-Mendoza, Cinthya, Greipp, Patricia T., Xu, Xinjie, Ketterling, Rhett P., McPhail, Ellen D., King, Rebecca L., Peterson, Jess F., Vasmatzis, George, Baughn, Linda B.

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Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms by Penheiter, Alan R., Deelchand, Dinesh K., Kittelson, Emily, Damgard, Sibel Erdogan, Murphy, Stephen J., O'Brien, Daniel R., Bamlet, William R., Passow, Marie R., Smyrk, Thomas C., Couch, Fergus J., Vasmatzis, George, Port, John D., Marjańska, Małgorzata, Carlson, Stephanie K.

“…We used transcriptomic profiling and immunohistochemistry (IHC) to search for a functional imaging strategy to resolve common problems with morphological…”
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Modification of Human Hearing Loss by Plasma-Membrane Calcium Pump PMCA2 by Schultz, Julie M, Yang, Yandan, Caride, Ariel J, Filoteo, Adelaida G, Penheiter, Alan R, Lagziel, Ayala, Morell, Robert J, Mohiddin, Saidi A, Fananapazir, Lameh, Madeo, Anne C, Penniston, John T, Griffith, Andrew J

“…This study implicates a variant of a gene encoding PMCA2, a plasma-membrane calcium pump, in the degree of severity of hearing loss caused by the mutation of…”
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Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma by Wuertz, Ryan E., Couch, Fergus J., Vasmatzis, George, Bender, Claire E., Carlson, Stephanie K., Bamlet, William R., O’Brien, Daniel R., Rakhshan Rohakhtar, Fariborz, Felipe Lima, Joema, Hart, Steven N., Murphy, Stephen J., Erdogan, Sibel, Penheiter, Alan R., Smyrk, Thomas C.

“…We used a target-centric strategy to identify transporter proteins upregulated in pancreatic ductal adenocarcinoma (PDAC) as potential targets for a functional…”
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Neutralization capacity of measles virus H protein specific IgG determines the balance between antibody-enhanced infectivity and protection in microglial cells by Iankov, Ianko D., Penheiter, Alan R., Griesmann, Guy E., Carlson, Stephanie K., Federspiel, Mark J., Galanis, Evanthia

“…► We characterized infection-enhancing activity of IgG monoclonal antibodies (MAbs) against measles virus (MV) H protein. ► Partially neutralizing MAb CL55…”
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Prediction of Volatile Anesthetic Binding Sites in Proteins by Streiff, John H., Allen, Thomas W., Atanasova, Elena, Juranic, Nenad, Macura, Slobodan, Penheiter, Alan R., Jones, Keith A.

“…Computational methods designed to predict and visualize ligand protein binding interactions were used to characterize volatile anesthetic (VA) binding sites…”
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Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase by Juranić Nenad O., Jones Keith A., Penheiter Alan R., Hock Thomas J., Streiff John H.

“…The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the…”
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Kinetic Analysis of the Calmodulin-Binding Region of the Plasma Membrane Calcium Pump Isoform 4b by Penheiter, Alan R., Filoteo, Adelaida G., Penniston, John T., Caride, Ariel J.

“…The sequence L1086RRGQILWFRGLNRIQTQIKVVKAFHSS1113 (peptide C28) is responsible for calmodulin binding to PMCA4b. In this work, peptides following the above…”
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Intramolecular Interactions of the Regulatory Region with the Catalytic Core in the Plasma Membrane Calcium Pump by Padányi, Rita, Pászty, Katalin, Penheiter, Alan R., Filoteo, Adelaida G., Penniston, John T., Enyedi, Ágnes

“…The access of three proteases to their sites of cleavage was used as a measure of regulatory interactions in the plasma membrane Ca2+ pump isoform 4b (PMCA4b)…”
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Sodium Iodide Symporter (NIS)-Mediated Radiovirotherapy for Pancreatic Cancer by PENHEITER, Alan R, WEGMAN, Troy R, CLASSIC, Kelly L, DINGLI, David, BENDER, Claire E, RUSSELL, Stephen J, CARLSON, Stephanie K

“…We have previously shown the therapeutic efficacy of an engineered oncolytic measles virus expressing the sodium iodide symporter reporter gene (MV-NIS) in…”
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Development of monoclonal antibody-based immunoassays for detection of Helicobacter pylori neutrophil-activating protein by Iankov, Ianko D., Penheiter, Alan R., Carlson, Stephanie K., Galanis, Evanthia

“…Neutrophil-activating protein (NAP) is a major virulence factor expressed by Helicobacter pylori isolates associated with severe chronic gastroduodenal…”
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Epigenomics may begin to explain in vitro differential response to hypomethylating agents in MMR-D hypermethylated endometrial cancer by El Khoury, Louis Y, Lin, Wan Hsin, Smadbeck, James B, Barrett, Michael T, Sadeghian, Dorsay, McCune, Alexa F, Karagouga, Giannoula, Cheville, John C, Harris, Faye R, Kinsella, Lindsey M, Feathers, Ryan W, Schafer Klein, Janet L, Walther-Antonio, Marina Rs, Johnson, Sarah H, Penheiter, Alan R, Cucinella, Giuseppe, Schivardi, Gabriella, Bhagwate, Aditya, Borad, Mitesh J, Mansfield, Aaron S, Murphy, Stephen J, Mariani, Andrea, Vasmatzis, George, Anastasiadis, Panos Z, Weroha, Saravut J, Larish, Alyssa M

“…This work examines differences in chromatin accessibility, methylation, and response to DNA hypomethylating agents between mismatch repair-deficient and…”
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Characterization of the deafwaddler mutant of the rat plasma membrane calcium-ATPase 2 by Penheiter, Alan R., Filoteo, Adelaida G., Croy, Cynthia L., Penniston, John T.

“…The deafwaddler mutant in mice was the first spontaneous mutant discovered in the plasma membrane Ca 2+ pump (PMCA) [Street, V.A. et al., 1998, Nat. Genet. 19,…”
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Tryptophan 1093 Is Largely Responsible for the Slow Off Rate of Calmodulin from Plasma Membrane Ca2+ Pump 4b by Penheiter, Alan R., Caride, Ariel J., Enyedi, Ágnes, Penniston, John T.

“…Tryptophan 1093 resides in the 28-residue calmodulin-binding/autoinhibitory domain of the plasma membrane Ca2+ pump (PMCA). Previous studies with the isolated…”
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Interactions between beta‐2 adrenoceptor gene variation, cardiovascular control and dietary sodium in healthy young adults by Eisenach, John H., Schroeder, Darrell R., Pavey, Emily S., Penheiter, Alan R., Knutson, Jean N., Turner, Stephen T., Joyner, Michael J.

“…Key points Common single nucleotide polymorphisms in the beta‐2 adrenoceptor (ADRB2) gene influence cardiovascular function, but they exist in combinations…”
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Monitoring the initial delivery of an oncolytic measles virus encoding the human sodium iodide symporter to solid tumors using contrast-enhanced computed tomography by Penheiter, Alan R., Dingli, David, Bender, Claire E., Russell, Stephen J., Carlson, Stephanie K.

“…Background We aimed to determine the feasibility of monitoring viral delivery and initial distribution to solid tumors using iodinated contrast agent and…”
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Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain by Josephson, Matthew P., Sikkink, Laura A., Penheiter, Alan R., Burghardt, Thomas P., Ajtai, Katalin

“…► Cardiac myosin regulatory light chain (MYL2) is phosphorylated at S15. ► Smooth muscle myosin light chain kinase (smMLCK) is a ubiquitous kinase. ► It is a…”
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The Myosin C-Loop Is an Allosteric Actin Contact Sensor in Actomyosin by Ajtai, Katalin, Halstead, Miriam F, Nyitrai, Miklós, Penheiter, Alan R, Zheng, Ye, Burghardt, Thomas P

“…Actin and myosin form the molecular motor in muscle. Myosin is the enzyme performing ATP hydrolysis under the allosteric control of actin such that actin…”
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Asp1080 Upstream of the Calmodulin-binding Domain Is Critical for Autoinhibition of hPMCA4b by Pászty, Katalin, Penheiter, Alan R., Verma, Anil K., Padányi, Rita, Filoteo, Adelaida G., Penniston, John T., Enyedi, Ágnes

“…The role of the plasma membrane Ca2+ pump (PMCA) is to remove excess Ca2+from the cytosol to maintain low intracellular Ca2+ levels. Asp1080 lies within an…”
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