Search Results - "Penhallow, Becky"

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers by Menard, Laurence C, Fischer, Paul, Kakrecha, Bijal, Linsley, Peter S, Wambre, Erik, Liu, Maochang C, Rust, Blake J, Lee, Deborah, Penhallow, Becky, Manjarrez Orduno, Nataly, Nadler, Steven G

“…Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response…”
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Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors by Ross-Macdonald, Petra, de Silva, Heshani, Guo, Qi, Xiao, Hong, Hung, Chen-Yi, Penhallow, Becky, Markwalder, Jay, He, Liqi, Attar, Ricardo M, Lin, Tai-an, Seitz, Steven, Tilford, Charles, Wardwell-Swanson, Judith, Jackson, Donald

“…In developing inhibitors of the LIM kinases, the initial lead molecules combined potent target inhibition with potent cytotoxic activity. However, as…”
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Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities by Ji, Rui-Ru, de Silva, Heshani, Jin, Yisheng, Bruccoleri, Robert E, Cao, Jian, He, Aiqing, Huang, Wenjun, Kayne, Paul S, Neuhaus, Isaac M, Ott, Karl-Heinz, Penhallow, Becky, Cockett, Mark I, Neubauer, Michael G, Siemers, Nathan O, Ross-Macdonald, Petra

“…The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to…”
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Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity by Hunt, John T, Ding, Charles Z, Batorsky, Roberta, Bednarz, Mark, Bhide, Rajeev, Cho, Young, Chong, Saeho, Chao, Sam, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Francis Y. F, Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A, Ricca, Carol, Rose, William C, Schmidt, Robert, Slusarchyk, William A, Vite, Gregory, Manne, Veeraswamy

“…Continuing structure−activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors…”
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Discovery and Structure−Activity Relationships of Imidazole-Containing Tetrahydrobenzodiazepine Inhibitors of Farnesyltransferase by Ding, Charles Z, Batorsky, Roberta, Bhide, Rajeev, Chao, Hannguang J, Cho, Young, Chong, Saeho, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Frank, Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A, Ricca, Carol, Rose, William C, Schmidt, Robert, Slusarchyk, William A, Vite, Gregory, Yan, Ning, Manne, Veeraswamy, Hunt, John T

“…2,3,4,5-Tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepines were found to be potent inhibitors of farnesyltransferase (FT). A hydrophobic substituent at the…”
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Abstract 4687: Double positive (DP) CD4+CD8+ T cells with an exhausted phenotype in renal cell carcinoma (RCC) patients by Menard, Laurence, Fischer, Paul, Kakrecha, Bijal, Lee, Deborah, Penhallow, Becky, Orduno, Nataly Manjarrez, Nadler, Steven

“…Abstract Checkpoint inhibitors target the inhibitory receptors expressed by tumor infiltrating T cells in order to reinvigorate an anti-tumor immune response…”
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Abstract 5016: Antitumor activity of anti-PD-1 in combination with tyrosine kinase inhibitors in a preclinical renal cell carcinoma model by Masters, Gregg, Dito, Gennaro, Penhallow, Becky, Lewin, Anne, Kao, Henry, Jure-Kunkel, Maria N.

“…Abstract Introduction: Nivolumab (BMS-936558; MDX-1106; ONO-4538) is a fully human IgG4 programmed death-1 (PD-1) immune checkpoint inhibitor antibody that…”
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Abstract LB-127: From bench to bedside: Exploring OX40 receptor modulation in a phase 1/2a study of the OX40 costimulatory agonist BMS-986178 ± nivolumab (NIVO) or ipilimumab (IPI) in patients with advanced solid tumors by Wang, Rui, Feng, Yan, Hilt, Ed, Yuan, Xiling, Gao, Chan, Shao, Xiao, Sun, Yongliang, D'silva, Michael, Yang, Katherine, Penhallow, Becky, Bogdanoski, Goce, Anand, Rajesh, Pak, Irene, Greenawalt, Danielle, Klippel, Anke, Manjarrez-Orduno, Nataly, Neely, Robert, Quigley, Michael, Hedrick, Michael, Aanur, Praveen, Cao, Z

“…Abstract Background: Activation of OX40, a costimulatory protein in the tumor necrosis factor receptor super family, enhances T effector cell activation and…”
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Discovery and Structure−Activity Relationships of Imidazole-Containing Tetrahydrobenzodiazepine Inhibitors of Farnesyltransferase by Ding, Charles Z, Batorsky, Roberta, Bhide, Rajeev, Chao, Hannguang J, Cho, Young, Chong, Saeho, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Frank, Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A, Ricca, Carol, Rose, William C, Schmidt, Robert, Slusarchyk, William A, Vite, Gregory, Yan, Ning, Manne, Veeraswamy, Hunt, John T

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Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms by Wan, Honghe, Schroeder, Gretchen M, Hart, Amy C, Inghrim, Jennifer, Grebinski, James, Tokarski, John S, Lorenzi, Matthew V, You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J, Trainor, George L, Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S, Khan, Javed A, Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K, Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N, Pragalathan, Bala, Narayanan, Sankara, K.C, Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V

“…JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential for the treatment of other…”
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Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists by Schroeder, Gretchen M., Wei, Donna, Banfi, Patrizia, Cai, Zhen-Wei, Lippy, Jonathan, Menichincheri, Maria, Modugno, Michele, Naglich, Joseph, Penhallow, Becky, Perez, Heidi L., Sack, John, Schmidt, Robert J., Tebben, Andrew, Yan, Chunhong, Zhang, Liping, Galvani, Arturo, Lombardo, Louis J., Borzilleri, Robert M.

“…5-Butyl-1,4-diphenyl pyrazole and 2-amino-5-chloro pyrimidine acylsulfonamides were developed as potent dual antagonists of Bcl-2 and Bcl-xL. Compounds were…”
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Modulation of cofilin phosphorylation by inhibition of the Lim family kinases by He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An

“…The design, synthesis, and SAR for a series of aminothiazole pyrimidines as potent LIMK inhibitors are described. Compound 31 effectively inhibited cofilin…”
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Characterization of BMS-911543, a Functionally Selective Small Molecule Inhibitor of JAK2 by Purandare, Ashok V, Pardanani, Animesh, McDevitt, Theresa, Gottardis, Marco, Lasho, Terra, You, Dan, Lombardo, Louis, Penhallow, Becky, Vuppugalla, Ragini, Trainor, George, Tefferi, Ayalew, Lorenzi, Matthew

“…Abstract 4112 We report the characterization of BMS-911543, a potent and functionally selective small molecule inhibitor of the Janus kinase family (JAK)…”
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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation by Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B

“…Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell receptor (TCR) signaling. Gene knockout studies have…”
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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors by Das, Jagabandhu, Furch, Joseph A., Liu, Chunjian, Moquin, Robert V., Lin, James, Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Doweyko, Arthur M., Kamath, Amrita, Zhang, Hongjian, Marathe, Punit, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

“…A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure–activity relationships (SARs),…”
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Abstract DDT01-03: Discovery of BMS-911543, a highly selective JAK2 inhibitor, as a clinical candidate for the treatment of myeloproliferative disease and other malignancies by Purandare, Ashok V., Wan, Honghe, Schroeder, Gretchen, Hart, Amy, Grebinski, James, Inghrim, Jennifer, Tokarski, John, You, Dan, Penhallow, Becky, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Ruepp, Stefan, Trainor, George, Han, Xia, Lombardo, Louis, Lee, Francis Y., Gottardis, Marco, Hosbach, Jennifer, Fitzpatrick, Elizabeth, Emanuel, Stuart, Pardanani, Animesh, Lasho, Terra L., Tefferi, Ayalew, Lorenzi, Matthew V.

“…Abstract Myeloproliferative diseases (MPDs) are a subset of myeloid malignancies that are characterized by the expansion of a multipotent hematopoietic stem…”
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Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities: e1000512 by Ji, Rui-Ru, Silva, Heshani de, Jin, Yisheng, Bruccoleri, Robert E, Cao, Jian, He, Aiqing, Huang, Wenjun, Kayne, Paul S, Neuhaus, Isaac M, Ott, Karl-Heinz, Penhallow, Becky, Cockett, Mark I, Neubauer, Michael G, Siemers, Nathan O, Ross-Macdonald, Petra

“…The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to…”
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Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors by Das, Jagabandhu, Liu, Chunjian, Moquin, Robert V., Lin, James, Furch, Joseph A., Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

“…A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure–activity relationships (SARs),…”
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Corrigendum to “Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors” [Bioorg. Med. Chem. Lett. 16 (2006) 2411–2415] by Das, Jagabandhu, Liu, Chunjian, Moquin, Robert V., Lin, James, Furch, Joseph A., Spergel, Steven H., Doweyko, Arthur M., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

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Discovery of ( R )-7-Cyano-2,3,4,5-tetrahydro-1-(1 H -imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1 H -1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity by Hunt, John T., Ding, Charles Z., Batorsky, Roberta, Bednarz, Mark, Bhide, Rajeev, Cho, Young, Chong, Saeho, Chao, Sam, Gullo-Brown, Johnni, Guo, Peng, Kim, Soong Hoon, Lee, Francis Y. F., Leftheris, Katerina, Miller, Arthur, Mitt, Toomas, Patel, Manorama, Penhallow, Becky A., Ricca, Carol, Rose, William C., Schmidt, Robert, Slusarchyk, William A., Vite, Gregory, Manne, Veeraswamy

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