In vivo biocompatibility of silicon dioxide nanofilm used as antimicrobial agent on acrylic surface

the focus ofthis study was to testthe hypothesisthatthere would be no difference betweenthe biocompatibility of silicon dioxide nanofilms used as antimicrobial agents. Sixty male Wistar rats were divided into 4 groups (n=15): Group C (Control,Polyethylene), Group AR (Acrylic Resin), Group NP (Acryli...

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Published in:	Anais da Academia Brasileira de Ciências Vol. 92; no. 1; p. e20181120
Main Authors:	Lacerda-Santos, Rogério, Lima, Antonia Bárbara L, Penha, Elizandra S DA, Santos, Antonielson Dos, Carvalho, Fabíola G, Pithon, Matheus M, Dantas, Antônio Flávio M
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 01-01-2020
Subjects:	Acrylic Resins - chemistry Acrylic Resins - pharmacology Animals biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology biomaterials dentistry Edema - chemically induced Edema - pathology inflammation Male Materials Testing Models, Animal MULTIDISCIPLINARY SCIENCES Necrosis - chemically induced Necrosis - pathology Rats Rats, Wistar Silicon Dioxide - chemistry Silicon Dioxide - pharmacology Subcutaneous Tissue - drug effects Subcutaneous Tissue - pathology biomaterials biocompatibility dentistry inflammation
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Summary:	the focus ofthis study was to testthe hypothesisthatthere would be no difference betweenthe biocompatibility of silicon dioxide nanofilms used as antimicrobial agents. Sixty male Wistar rats were divided into 4 groups (n=15): Group C (Control,Polyethylene), Group AR (Acrylic Resin), Group NP (Acrylic Resin coated with NP-Liquid), Group BG (Acrylic Resin coated with Bacterlon).the animals were sacrificed with 7,15 and 30 days and tissues analyzed as regardsthe events of inflammatory infiltrate, edema, necrosis, granulation tissue, mutinucleated giant cells, fibroblasts and collagen. Kruskal-Wallis and Dunn tests was used (P<0.05). Intense inflammatory infiltrate was shown mainly in Groups BG and AR, with significant difference from Control Group inthe time interval of 7days (P=0.004). Necrosis demonstrated significant difference between Group BG and Control Group (P<0.05) inthe time intervals of 7 days. For collagen fibers,there was significant difference betweenthe Control Group and Groups AR and BG inthe time interval of 7 days (P=0.006), and between BG and Control Groups inthe time intervals of 15 days (P=0.010).the hypothesis was rejected. Bacterlon demonstratedthe lowest level, and NP-Liquid Glassthe highest level of tissue compatibility, and best cell repair.the coating with NP-Liquid Glass was demonstrated to be highly promising for clinical use.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690
DOI:	10.1590/0001-3765202020181120