Search Results - "Penha, Carlos"

Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective by Penha-Gonçalves, Carlos

“…Despite significant progress in combating malaria in recent years the burden of severe disease and death due to infections remains a global public health…”
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Portuguese Society of Immunology (SPI): Turning 50, inspired by the past, looking into the future by Caramalho, Iris, Almeida, Maria Strecht, Vilanova, Manuel, Penha‐Gonçalves, Carlos

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Individual variation in susceptibility or exposure to SARS-CoV-2 lowers the herd immunity threshold by Gomes, M. Gabriela M., Ferreira, Marcelo U., Corder, Rodrigo M., King, Jessica G., Souto-Maior, Caetano, Penha-Gonçalves, Carlos, Gonçalves, Guilherme, Chikina, Maria, Pegden, Wesley, Aguas, Ricardo

“…[Display omitted] •Variation in susceptibility/exposure responds to selection by natural infection.•Selection on susceptibility/exposure flattens epidemic…”
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Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies by Alenquer, Marta, Ferreira, Filipe, Lousa, Diana, Valério, Mariana, Medina-Lopes, Mónica, Bergman, Marie-Louise, Gonçalves, Juliana, Demengeot, Jocelyne, Leite, Ricardo B, Lilue, Jingtao, Ning, Zemin, Penha-Gonçalves, Carlos, Soares, Helena, Soares, Cláudio M, Amorim, Maria João

“…Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19 pandemics. At the core is an arms-race between SARS-CoV-2 antibody and…”
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Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis by Coll, Francesc, Phelan, Jody, Hill-Cawthorne, Grant A., Nair, Mridul B., Mallard, Kim, Ali, Shahjahan, Abdallah, Abdallah M., Alghamdi, Saad, Alsomali, Mona, Ahmed, Abdallah O., Portelli, Stephanie, Oppong, Yaa, Alves, Adriana, Bessa, Theolis Barbosa, Campino, Susana, Caws, Maxine, Chatterjee, Anirvan, Crampin, Amelia C., Dheda, Keertan, Furnham, Nicholas, Glynn, Judith R., Grandjean, Louis, Minh Ha, Dang, Hasan, Rumina, Hasan, Zahra, Hibberd, Martin L., Joloba, Moses, Jones-López, Edward C., Matsumoto, Tomoshige, Miranda, Anabela, Moore, David J., Mocillo, Nora, Panaiotov, Stefan, Parkhill, Julian, Penha, Carlos, Perdigão, João, Portugal, Isabel, Rchiad, Zineb, Robledo, Jaime, Sheen, Patricia, Shesha, Nashwa Talaat, Sirgel, Frik A., Sola, Christophe, Oliveira Sousa, Erivelton, Streicher, Elizabeth M., Helden, Paul Van, Viveiros, Miguel, Warren, Robert M., McNerney, Ruth, Pain, Arnab, Clark, Taane G.

“…To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium…”
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Intravital imaging of host‐parasite interactions in organs of the thoracic and abdominopelvic cavities by De Niz, Mariana, Carvalho, Tânia, Penha‐Gonçalves, Carlos, Agop‐Nersesian, Carolina

“…Infections with protozoan and helminthic parasites affect multiple organs in the mammalian host. Imaging pathogens in their natural environment takes a more…”
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Brain Endothelium: The "Innate Immunity Response Hypothesis" in Cerebral Malaria Pathogenesis by Pais, Teresa F, Penha-Gonçalves, Carlos

“…Cerebral malaria (CM) is a life-threatening neurological syndrome caused by infection afflicting mainly children in Africa. Current pathogenesis models…”
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Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage by Coelho, Inês, Duarte, Nádia, Barros, André, Macedo, Maria Paula, Penha-Gonçalves, Carlos

“…Macrophages are pivotal in mounting liver inflammatory and tissue repair responses upon hepatic injury, showing remarkable functional plasticity. The molecular…”
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Maternal-Fetal Conflict During Infection: Lessons From a Mouse Model of Placental Malaria by Pandya, Yash, Penha-Gonçalves, Carlos

“…Infections that reach the placenta via maternal blood can target the fetal-placental barrier and are associated with reduced birth weight, increased…”
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Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges by Faro-Viana, João, Bergman, Marie-Louise, Gonçalves, Lígia A., Duarte, Nadia, Coutinho, Teresa P., Borges, Patricia C., Diwo, Christian, Castro, Rute, ..., Landeiro Raposo Pina Nunes, Telmo Renato, et al

“…While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at…”
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How Inflammation Impinges on NAFLD: A Role for Kupffer Cells by Penha-Gonçalves, Carlos, Almeida, Joana I., Patarrão, Rita S., Coelho, Inês C., Duarte, Nádia, Macedo, M. Paula

“…Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently…”
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TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria by Pandya, Yash, Marta, Alexander, Barateiro, André, Bandeira, Carla Letícia, Dombrowski, Jamille Gregório, Costa, João, Marinho, Cláudio Romero Farias, Penha-Gonçalves, Carlos

“…Pregnancy-associated malaria is often associated with adverse pregnancy outcomes. Placental circulatory impairments are an intriguing and unsolved component of…”
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The rare DRB104:08-DQ8 haplotype is the main HLA class II genetic driver and discriminative factor of Early-onset Type 1 diabetes in the Portuguese population by Caramalho, Iris, Matoso, Paula, Ligeiro, Dário, Paixão, Tiago, Sobral, Daniel, Fitas, Ana Laura, Limbert, Catarina, Demengeot, Jocelyne, Penha-Gonçalves, Carlos

“…Early-onset Type 1 diabetes (EOT1D) is considered a disease subtype with distinctive immunological and clinical features. While both Human Leukocyte Antigen…”
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Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits by Borges, Diego O., Patarrão, Rita S., Ribeiro, Rogério T., de Oliveira, Rita Machado, Duarte, Nádia, Belew, Getachew Debas, Martins, Madalena, Andrade, Rita, Costa, João, Correia, Isabel, Boavida, José Manuel, Duarte, Rui, Gardete-Correia, Luís, Medina, José Luís, Raposo, João F., Jones, John G., Penha-Gonçalves, Carlos, Macedo, M. Paula

“…Systemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is…”
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Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target by Duarte, Nádia, Shafi, Abdul Muktadir, Penha-Gonçalves, Carlos, Pais, Teresa Faria

“…The endothelium layer lining the inner surface of blood vessels serves relevant physiological functions in all body systems, including the exchanges between…”
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Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism by Shafi, Abdul Muktadir, Végvári, Ákos, Zubarev, Roman A, Penha-Gonçalves, Carlos

“…Cerebral malaria (CM) lethality is attributable to induction of brain edema induction but the cellular mechanisms involving brain microvascular endothelium in…”
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Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity by Ribeiro, Andreia Fiúza, Fitas, Ana Laura, Pires, Marcela Oliveira, Matoso, Paula, Ligeiro, Dário, Sobral, Daniel, Penha-Gonçalves, Carlos, Demengeot, Jocelyne, Caramalho, Íris, Limbert, Catarina

“…This study is aimed at comparing whole exome sequencing (WES) data with the clinical presentation in children with type 1 diabetes onset ≤ 5 years of age…”
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TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection by Gonçalves, Lígia Antunes, Rodrigues-Duarte, Lurdes, Rodo, Joana, de Moraes, Luciana Vieira, Marques, Isabel, Penha-Gonçalves, Carlos

“…Plasmodium liver stage infection is a target of interest for the treatment of and vaccination against malaria. Here we used forward genetics to search for…”
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Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola by Sebastião, Cruz S, Cogle, Adis, Teixeira, Alice D'Alva, Cândido, Ana Micolo, Tchoni, Chissengo, Amorim, Maria João, Loureiro, N'gueza, Parimbelli, Paolo, Penha-Gonçalves, Carlos, Demengeot, Jocelyne, Sacomboio, Euclides, Mendes, Manuela, Arrais, Margarete, Morais, Joana, Vasconcelos, Jocelyne Neto de, Brito, Miguel

“…Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies…”
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Association of BANK1 and cytokine gene polymorphisms with type 1 diabetes in Tunisia by Zouidi, Ferjani, Stayoussef, Mouna, Bouzid, Dorra, Fourati, Hajer, Abida, Olfa, João, Costa, Ayed, Mourad Ben, Fakhfakh, Raouia, Thouraya, Kammoun, Monjia, Hachicha, Carlos, Penha-Gonçalves, Masmoudi, Hatem

“…Type 1 diabetes (T1D) is an autoimmune disease (AID) with both genetic and environmental components. We aimed to investigate the genetic association of…”
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