Search Results - "Peng, W. K."

Using clinically approved cyclophosphamide regimens to control the humoral immune response to oncolytic viruses by Peng, K-W, Myers, R, Greenslade, A, Mader, E, Greiner, S, Federspiel, M J, Dispenzieri, A, Russell, S J

“…Oncolytic viruses can be neutralized in the bloodstream by antiviral antibodies whose titers increase progressively with each exposure, resulting in faster…”
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Curative one-shot systemic virotherapy in murine myeloma by Naik, S, Nace, R, Federspiel, M J, Barber, G N, Peng, K-W, Russell, S J

“…Current therapy for multiple myeloma is complex and prolonged. Antimyeloma drugs are combined in induction, consolidation and/or maintenance protocols to…”
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Overcoming cancer cell resistance to VSV oncolysis with JAK1/2 inhibitors by Escobar-Zarate, D, Liu, Y-P, Suksanpaisan, L, Russell, S J, Peng, K-W

“…Oncolytic vesicular stomatitis virus (VSV) has potent antitumor activity but some cancer cells are resistant to VSV killing, either constitutively or due to…”
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First trimester caesarean scar ectopic pregnancy evaluation using MRI by Peng, K.-W, Lei, Z, Xiao, T.-H, Jia, F.-G, Zhong, W.-X, Gao, Y, Shen, B.-X, Xie, J.-W

“…Aim To determine the features of caesarean scar ectopic pregnancy (CSP) by using magnetic resonance imaging (MRI) in the first trimester. Materials and methods…”
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Evaluation of T cells as carriers for systemic measles virotherapy in the presence of antiviral antibodies by ONG, H. T, HASEGAWA, K, DIETZ, A. B, RUSSELL, S. J, PENG, K.-W

“…Neutralizing antiviral antibodies (Abs) can hinder systemic virotherapy. Here, we used activated T cells as carriers to deliver oncolytic measles viruses (MV)…”
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Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy with Lobaplatin and Docetaxel to Treat Synchronous Peritoneal Carcinomatosis from Gastric Cancer: Results from a Chinese Center by Wu, Hai-Tao, MD, Peng, Kai-Wen, MD, Ji, Zhong-He, MD, Sun, Jian-Hua, MD, Zhang, Qian, MD, Yang, Xiao-Jun, MD, PhD, Huang, Chao-Qun, MD, PhD, Li, Yan, MD, PhD

“…Abstract Background This work was to evaluate the efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC)…”
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Preclinical Pharmacology and Toxicology of Intravenous MV-NIS, an Oncolytic Measles Virus Administered With or Without Cyclophosphamide by Myers, R M, Greiner, S M, Harvey, M E, Griesmann, G, Kuffel, M J, Buhrow, S A, Reid, J M, Federspiel, M, Ames, M M, Dingli, D, Schweikart, K, Welch, A, Dispenzieri, A, Peng, K‐W, Russell, S J

“…MV‐NIS is an oncolytic measles virus encoding the human thyroidal sodium iodide symporter (NIS). Here, we report the results of preclinical pharmacology and…”
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Role of liver function tests in predicting common bile duct stones in acute calculous cholecystitis by Peng, W. K., Sheikh, Z., Paterson-Brown, S., Nixon, S. J.

“…Background: The role of liver function tests (LFTs) in evaluating common bile duct (CBD) stones in patients with cholelithiasis has been studied widely…”
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Dynamics of multiple myeloma tumor therapy with a recombinant measles virus by Dingli, D, Offord, C, Myers, R, Peng, K-W, Carr, T W, Josic, K, Russell, S J, Bajzer, Z

“…Replication-competent viruses are being tested as tumor therapy agents. The fundamental premise of this therapy is the selective infection of the tumor cell…”
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High scFv–receptor affinity does not enhance the antitumor activity of HER2-retargeted measles virus by Suksanpaisan, L, Russell, S J, Peng, K-W

“…The relationship between ligand–receptor affinity and antitumor potency of an oncolytic virus was investigated using a panel of six HER2/neu (HER2)-targeted…”
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Electrophoretic deposition of porous hydroxyapatite scaffold by Ma, J., Wang, C., Peng, K.W.

“…Bioactive porous hydroxyapatite (HA) scaffold was fabricated using electrophoretic deposition (EPD) technique in the present work. Bulk HA scaffold was…”
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Role of laparoscopic cholecystectomy in the early management of acute gallbladder disease by Peng, W. K., Sheikh, Z., Nixon, S. J., Paterson-Brown, S.

“…Background: This study evaluated the role of laparoscopic surgery in the early management of acute gallbladder disease in a single large UK teaching hospital…”
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Oral contrast enhances the resolution of in-life NIS reporter gene imaging by Suksanpaisan, L, Pham, L, McIvor, S, Russell, S J, Peng, K-W

“…Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the…”
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Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy by Reddi, H V, Madde, P, McDonough, S J, Trujillo, M A, Morris, J C, Myers, R M, Peng, K W, Russell, S J, McIver, B, Eberhardt, N L

“…Anaplastic thyroid cancer is an extremely aggressive disease resistant to radioiodine treatment because of loss of sodium iodide symporter (NIS) expression. To…”
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Polyinosinic acid decreases sequestration and improves systemic therapy of measles virus by Liu, Y-P, Tong, C, Dispenzieri, A, Federspiel, M J, Russell, S J, Peng, K-W

“…Off-target binding or vector sequestration can significantly limit the efficiency of systemic virotherapy. We report here that systemically administered…”
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Noninvasive dual modality in vivo monitoring of the persistence and potency of a tumor targeted conditionally replicating adenovirus by KANERVA, A, ZINN, K. R, ALFTHAN, H, STENMAN, U.-H, CURIEL, D. T, HEMMINKI, A, PENG, K.-W, RANKI, T, KANGASNIEMI, L, CHAUDHURI, T. R, DESMOND, R. A, WANG, M, TAKAYAMA, K, HAKKARAINEN, T

“…In clinical trials with cancer patients, the safety of conditionally replicating adenoviruses (CRAds) has been good. However, marginal data are available on…”
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Pharmacokinetics of oncolytic measles virotherapy: eventual equilibrium between virus and tumor in an ovarian cancer xenograft model by Peng, K-W, Hadac, E M, Anderson, B D, Myers, R, Harvey, M, Greiner, S M, Soeffker, D, Federspiel, M J, Russell, S J

“…Because of their ability to replicate, the dose-response relationships of oncolytic viruses cannot easily be predicted. To better understand the…”
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Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors by PENG, K-W, PHAM, L, YE, H, ZUFFEREY, R, TRONO, D, COSSET, F-L, RUSSELL, S. J

“…Lentiviral vectors represent an attractive technology platform from which to develop a targetable injectable gene delivery system for transduction of specific…”
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Phase I trial of systemic administration of Edmonston strain of measles virus genetically engineered to express the sodium iodide symporter in patients with recurrent or refractory multiple myeloma by Dispenzieri, A, Tong, C, LaPlant, B, Lacy, M Q, Laumann, K, Dingli, D, Zhou, Y, Federspiel, M J, Gertz, M A, Hayman, S, Buadi, F, O'Connor, M, Lowe, V J, Peng, K-W, Russell, S J

“…MV-NIS is an Edmonston lineage oncolytic measles virus expressing the human sodium iodide symporter—a means for monitoring by non-invasive imaging of…”
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Measles virus for cancer therapy by Russell, S J, Peng, K W

“…Measles virus offers an ideal platform from which to build a new generation of safe, effective oncolytic viruses. Occasional so-called spontaneous tumor…”
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