Search Results - "Peng, Rujue"

Research progress and development strategy of PI3K inhibitors for breast cancer treatment: A review (2016-present) by Peng, Rujue, Zhan, Yujie, Li, Anqi, Lv, Qiaoli, Xu, Shan

“…PI3K/mTOR inhibitors are effective drugs for breast cancer. In this paper, we review the mechanism of action of PI3K/AKT/mTOR inhibitors, as well as the…”
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Coordination-Driven Self-Assembly of Metal Ion–Antisense Oligonucleotide Nanohybrids for Chronic Bacterial Infection Therapy by Li, Anqi, Zhang, Yan, Wan, Li, Peng, Rujue, Zhang, Xuan, Guo, Qiuyan, Xu, Shan, Qiao, Dan, Zheng, Pengwu, Li, Na, Zhu, Wufu, Pan, Qingshan

“…Bacterial infection poses a significant challenge to wound healing and skin regeneration, leading to substantial economic burdens on patients and society…”
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Based on virtual screening methods and biological activity assessment, AK-968/13030056 has been identified as a potential mTOR inhibitor by Yang, Yang, Peng, Rujue, Cheng, Zhenjie, Yu, MengTing, Fu, Li, Zhang, Xufei, Zheng, Pengwu, Zhu, Wufu, Wang, Linxiao, Xu, Shan

“…•Established a virtual screening workflow for mTOR inhibitors.•A compound with potent mTOR kinase inhibitory activity was ultimately screened.•AK-968/13030056…”
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Discovery of novel potent PI3K/mTOR dual‐target inhibitors based on scaffold hopping: Design, synthesis, and antiproliferative activity by Yang, Yang, Sun, Xin, Luo, Leixuan, Peng, Rujue, Yang, Ruiqing, Cheng, Zhenjie, Lv, Yao, Li, Hongfeng, Tang, Qidong, Zhu, Wufu, Qiao, Dan, Xu, Shan

“…The PI3K/AKT/mTOR pathway is one of the most common dysregulated signaling cascade responses in human cancers, playing a crucial role in cell proliferation and…”
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Photothermally Enhanced Cascaded Nanozyme-Functionalized Black Phosphorus Nanosheets for Targeted Treatment of Infected Diabetic Wounds by Wen, Chunping, Zhang, Yan, Lai, Luogen, Zhang, Xuan, Liu, Yijun, Guo, Qiuyan, Peng, Rujue, Gao, Yating, Zhang, Xufei, He, Yan, Xu, Shan, Qiao, Dan, Zheng, Pengwu, Pan, Qingshan, Zhu, Wufu

“…Due to the limitations of H O under physiological conditions and defective activity, nanozyme-catalyzed therapy for infected diabetic wound healing is still a…”
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