Search Results - "Peng, Qianping"

A Convenient Strategy for Quantitative Determination of Drug Concentrations in Tissue Homogenates Using a Liquid Chromatography/Tandem Mass Spectrometry Assay for Plasma Samples by Jiang, Hao, Zeng, Jianing, Zheng, Naiyu, Kandoussi, Hamza, Peng, Qianping, Valentine, Jack L, Lange, Robert W, Arnold, Mark E

“…Quantitative determination of drug concentrations in tissue homogenates via liquid chromatography–tandem mass spectrometry (LC-MS/MS) is commonly conducted…”
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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity by He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Bakshi, Raman K., Hong, Qingmei, Dellureficio, James P., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Reibarkh, Mikhail, Holmes, Mark A., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., Wyvratt, Matthew J., Nargund, Ravi P.

“…We report an SAR study of MC4R analogs containing spiroindane heterocyclic privileged structures. Compound 26 with N-Me-1,2,4-triazole moiety possesses…”
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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity by Hadden, Mark, Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J., Swenson, Brian, Yet, Larry, Liu, Jian, He, Shuwen, Sebhat, Iyassu K., Lin, Linus S., Tamvakopoulos, Constantin, Peng, Qianping, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Metzger, Joseph M., Reitman, Marc L., Nargund, Ravi P.

“…SAR around non-peptidic potent bombesin receptor subtype-3 (BRS-3) agonist lead 2 is presented. Attempts to replace the carboxylic acid with heterocyclic…”
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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity by Liu, Jian, He, Shuwen, Jian, Tianying, Dobbelaar, Peter H., Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J, Swenson, Brian, Yet, Larry, Tamvakopoulos, Constantin, Peng, Qianping, Pan, Jie, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Howard, Andrew D., Marsh, Donald J., Metzger, Joseph M., Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P.

“…A series of 2-biarylethylimidazole analogues were synthesized as BRS-3 selective agonists. Compound 9 was identified as a potent and selective BRS-3 agonist,…”
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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists by He, Shuwen, Dobbelaar, Peter H., Liu, Jian, Jian, Tianying, Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Ruenz, Megan, Sargent, Bruce J., Yet, Larry, Kelly, Theresa M., Palyha, Oksana, Kan, Yanqing, Pan, Jie, Chen, Howard, Marsh, Donald J., Shearman, Lauren P., Strack, Alison M., Metzger, Joseph M., Feighner, Scott D., Tan, Carina, Howard, Andrew D., Tamvakopoulos, Constantin, Peng, Qianping, Guan, Xiao-Ming, Reitman, Marc L., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.

“…Extensive SAR studies of a series derived from RY-337, a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead, led to the discovery of compound…”
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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist by Hong, Qingmei, Bakshi, Raman K., Palucki, Brenda L., Park, Min K., Ye, Zhixiong, He, Shuwen, Pollard, Patrick G., Sebhat, Iyassu K., Liu, Jian, Guo, Liangqin, Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.

“…We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound…”
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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist by He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Tsou, Nancy N., Ball, Richard G., Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.

“…We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4…”
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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity by He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Weinberg, David H., MacNeil, Tanya, Tang, Rui, Strack, Alison M., Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Fong, Tung M., Wyvratt, Matthew J., Nargund, Ravi P.

“…We report a series of potent and selective MC4R agonists based on spiroindane amide privileged structures for potential treatments of obesity. Among the…”
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Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists by LIANGQIN GUO, ZHIXIONG YE, TSOU, Nancy N, BALL, Richard G, WEINBERG, David H, MACNEIL, Tanya, RUI TANG, TAMVAKOPOULOS, Constantin, QIANPING PENG, CHEN, Howard Y, CHEN, Airu S, MARTIN, William J, JIAN LIU, EUAN MACINTYRE, D, STRACK, Alison M, FONG, Tung M, WYVRATT, Matthew J, NARGUND, Ravi P, SHUWEN HE, BAKSHI, Raman K, SEBHAT, Iyassu K, DOBBELAAR, Peter H, QINGMEI HONG, TIANYING JIAN, DELLUREFICIO, James P

“…Design, synthesis, and SAR of a series of 3H-spiro[isobenzofuran-1,4'-piperidine] based compounds as potent, selective and orally bioavailable melanocortin…”
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Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators by Guo, Liangqin, Ye, Zhixiong, Ujjainwalla, Feroze, Sings, Heather L., Sebhat, Iyassu K., Huber, John, Weinberg, David H., Tang, Rui, MacNeil, Tanya, Tamvakopoulos, Constantin, Peng, Qianping, MacIntyre, Euan, van der Ploeg, Lex H.T., Goulet, Mark T., Wyvratt, Matthew J., Nargund, Ravi P.

“…Discovery of a series of tert-butyl pyrrolidine derived, potent and orally bioavailable melanocortin receptor subtype-4 (MC4R) selective modulators is…”
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2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists by Palucki, Brenda L., Park, Min K., Nargund, Ravi P., Tang, Rui, MacNeil, Tanya, Weinberg, David H., Vongs, Aurawan, Rosenblum, Charles I., Doss, George A., Miller, Randall R., Stearns, Ralph A., Peng, Qianping, Tamvakopoulos, Constantin, Van der Ploeg, Lex H.T., Patchett, Arthur A.

“…[Display omitted] We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin…”
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Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC–MS/MS assay by Yuan, Long, Fu, Yunlin, Zhang, Duxi, Xia, Yuan-Qing, Peng, Qianping, Aubry, Anne-Françoise, Arnold, Mark E.

“…•Identification of PMSF as an effective stabilizer for epothilone D in rat plasma.•A sensitive, accurate and rugged UHPLC–MS/MS method for epothilone D in rat…”
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A rugged and accurate liquid chromatography–tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma by Yuan, Long, Jiang, Hao, Ouyang, Zheng, Xia, Yuan-Qing, Zeng, Jianing, Peng, Qianping, Lange, Robert W., Deng, Yuzhong, Arnold, Mark E., Aubry, Anne-Françoise

“…► Developed and validated a rugged and accurate method for the determination of asunaprevir in plasma. ► A systematic method optimization strategy achieved…”
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A rapid, accurate and robust UHPLC–MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies by Zheng, Naiyu, Zeng, Jianing, Akinsanya, Billy, Buzescu, Adela, Xia, Yuan-Qing, Ly, Van, Trouba, Kevin, Peng, Qianping, Aubry, Anne-Françoise, Arnold, Mark E.

“…•A robust assay was validated to quantify BMS-927711, a drug candidate, in plasma.•A simplified method optimization strategy was used to develop this robust…”
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A simplified and completely automated workflow for regulated LC–MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction by Zheng, Naiyu, Buzescu, Adela, Pasas-Farmer, Stephanie, Arnold, Mark E., Ouyang, Zheng, Jemal, Mohammed, Peng, Qianping, Van Vleet, Terry, Zeng, Jianing

“…► The workflow for regulated bioanalysis is simplified and fully automated. ► Cap-piercing direct sampling and evaporation-free solid phase extraction are…”
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Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS by Zheng, Naiyu, Zeng, Jianing, Ji, Qin C, Angeles, Aida, Buzescu, Adela, Basdeo, Shenita, Aubry, Anne-Françoise, Trouba, Kevin, Patrone, Laura M, Peng, Qianping, Arnold, Mark E

“…An UHPLC-MS/MS method was developed and validated to quantify BMS-927711, a drug candidate to treat migraine, in rat dried blood spots (DBS). The DBS samples…”
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Discovery of potent, selective, and orally bioavailable 3 H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists by Guo, Liangqin, Ye, Zhixiong, Liu, Jian, He, Shuwen, Bakshi, Raman K., Sebhat, Iyassu K., Dobbelaar, Peter H., Hong, Qingmei, Jian, Tianying, Dellureficio, James P., Tsou, Nancy N., Ball, Richard G., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Chen, Howard Y., Chen, Airu S., Martin, William J., MacIntyre, D. Euan, Strack, Alison M., Fong, Tung M., Wyvratt, Matthew J., Nargund, Ravi P.

“…Design, synthesis, structure–activity relationship, and in vivo pharmacological data of a series of 3 H-spiro[isobenzofuran-1,4’-piperidine] based compounds as…”
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Discovery of (2 S)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist by Palucki, Brenda L., Park, Min K., Nargund, Ravi P., Ye, Zhixiong, Sebhat, Iyassu K., Pollard, Patrick G., Kalyani, Rubana N., Tang, Rui, MacNeil, Tanya, Weinberg, David H., Vongs, Aurawan, Rosenblum, Charles I., Doss, George A., Miller, Randall R., Stearns, Ralph A., Peng, Qianping, Tamvakopoulos, Constantin, McGowan, Erin, Martin, William J., Metzger, Joseph M., Shepherd, Cherrie A., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A.

“…[Display omitted] We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin…”
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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist by Ye, Zhixiong, Guo, Liangqin, Barakat, Khaled J., Pollard, Patrick G., Palucki, Brenda L., Sebhat, Iyassu K., Bakshi, Raman K., Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, Chen, Airu S., Chen, Howard Y., Rosenblum, Charles I., MacNeil, Tanya, Weinberg, David H., Peng, Qianping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen E., Martin, William J., Metzger, Joseph M., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.

“…A novel isoquinuclidine containing selective melanocortin subtype-4 receptor small molecule agonist, 3 (RY764), is reported. Its in vivo characterization…”
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Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)-amino]carbonyl]-1-piperidin yl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist by PALUCKI, Brenda L, PARK, Min K, VONGS, Aurawan, ROSENBLUM, Charles I, DOSS, George A, MILLER, Randall R, STEARNS, Ralph A, QIANPING PENG, TAMVAKOPOULOS, Constantin, MCGOWAN, Erin, MARTIN, William J, METZGER, Joseph M, NARGUND, Ravi P, SHEPHERD, Cherrie A, STRACK, Alison M, MACINTYRE, D. Euan, VAN DER PLOEG, Lex H. T, PATCHETT, Arthur A, ZHIXIONG YE, SEBHAT, Iyassu K, POLLARD, Patrick G, KALYANI, Rubana N, RUI TANG, MACNEIL, Tanya, WEINBERG, David H

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