Search Results - "Peng, Luxin"
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Profiling stress-triggered RNA condensation with photocatalytic proximity labeling
Published in Nature communications (15-11-2023)“…Stress granules (SGs) are highly dynamic cytoplasmic membrane-less organelles that assemble when cells are challenged by stress. RNA molecules are sorted into…”
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2
MRGPRX4 is a bile acid receptor for human cholestatic itch
Published in eLife (10-09-2019)“…Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as…”
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3
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons
Published in Nature chemistry (01-05-2021)“…Membrane potential is a key aspect of cellular signalling and is dynamically regulated by an array of ion-selective pumps and channels. Fluorescent voltage…”
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4
Supertemporal Resolution Imaging of Membrane Potential via Stroboscopic Microscopy
Published in Chemical & biomedical imaging (28-08-2023)“…Membrane potential and its fluctuation are fundamental biophysical phenomena essential to cellular activities and functions. Compared to traditional…”
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5
Immunoproximity biotinylation reveals the axon initial segment proteome
Published in Nature communications (11-12-2023)“…The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the…”
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Hybrid Indicators for Fast and Sensitive Voltage Imaging
Published in Angewandte Chemie International Edition (03-04-2018)“…Membrane voltage is an important biophysical signal that underlies intercellular electrical communications. A fluorescent voltage indicator is presented that…”
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7
Genetically-encoded voltage indicators
Published in Chinese chemical letters (01-10-2017)“…A holy grail in neuroscience is to understand how brain functions arise from neural network-level electrical activities. Voltage imaging allows for the direct…”
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O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95
Published in Nature chemistry (01-07-2022)Get full text
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O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95
Published in Nature chemistry (01-07-2022)“…Liquid–liquid phase separation (LLPS) of SynGAP and PSD-95, two abundant proteins that interact in the postsynaptic density (PSD) of neurons, has been…”
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10
CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons
Published in Molecular cell (05-01-2023)“…Nonsense mutations, accounting for >20% of disease-associated mutations, lead to premature translation termination. Replacing uridine with pseudouridine in…”
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11
Orange/far-red hybrid voltage indicators with reduced phototoxicity enable reliable long-term imaging in neurons and cardiomyocytes
Published in Proceedings of the National Academy of Sciences - PNAS (22-08-2023)“…Hybrid voltage indicators (HVIs) are chemogenetic sensors that combines the superior photophysical properties of organic dyes and the genetic targetability of…”
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12
Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials
Published in Neuroscience bulletin (01-11-2022)“…The back-propagating action potential (bpAP) is crucial for neuronal signal integration and synaptic plasticity in dendritic trees. Its properties (velocity…”
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13
Imaging Neuronal Activity with Fast and Sensitive Red-Shifted Electrochromic FRET Indicators
Published in ACS chemical neuroscience (18-12-2019)“…Genetically encoded voltage indicators (GEVIs) allow optical recording of neuronal activities with high spatial resolution. While most existing GEVIs emit in…”
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Differences in action potential propagation speed and axon initial segment plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice
Published in Dōngwùxué yánjiū (18-07-2022)“…Action potentials (APs) in neurons are generated at the axon initial segment (AIS). AP dynamics, including initiation and propagation, are intimately…”
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Corrigendum: Hybrid Indicators for Fast and Sensitive Voltage Imaging
Published in Angewandte Chemie International Edition (21-10-2019)Get full text
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Berichtigung: Hybrid Indicators for Fast and Sensitive Voltage Imaging
Published in Angewandte Chemie (21-10-2019)Get full text
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17
Hybrid Indicators for Fast and Sensitive Voltage Imaging
Published in Angewandte Chemie (03-04-2018)“…Membrane voltage is an important biophysical signal that underlies intercellular electrical communications. A fluorescent voltage indicator is presented that…”
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18
一氧化碳中毒迟发性脑病与脑细胞自噬的研究进展
Published in 中国临床医学 (2018)“…R595.1; 一氧化碳中毒迟发性脑病(delayed encephalopathy after carbon monoxide…”
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